“…Since HBV infection was found to be one of the most common risk factors for the development of ICC in the last decade, efforts of a number of doctors and researchers have considered that HBV-associated ICC is a malignancy of distinctive characteristics, including relatively infrequent lymph node metastasis, predominance of male patients, frequent elevation of alphafetoprotein, etc. [2][3][4][5] Most importantly, both the preoperative and postoperative extrahepatic metastases are less common in this subtype, which might have contributed to significantly better survival outcomes of the patients who received AVT by controlling the local recurrence after hepatectomy. 6 Furthermore, in the study by Lei et al 1 results of the multivariate analysis showed that HBV-DNA level was the most underpowered variable for OS and recurrence of the tumor, compared to other variables, such as nodal metastasis, tumor diameter, and tumor number.…”