Retrieval-extinction as a reconsolidation-based treatment for emotional disorders:Evidence from an extinction retention test shortly after intervention

Chen, Wei; Li, Junjiao; Zhang, Xiaoxia; Dong, Yuanyuan; Shi, Pei; Luo, Pinchao; Zheng, Xifu

doi:10.1016/j.brat.2021.103831

Cited by 13 publications

(19 citation statements)

References 65 publications

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“…• CS+ fear returns at 3 h but is gone at 24 h, as reported by Chen et al [67] and reviewed in Section A.20;…”

mentioning

confidence: 63%

“…P n/a n/a n/a n/a n/a n/a n/a n/a n/a [A.20] 2021 Chen [67] P 67% shock US pairing; both retrieval-extinction and extinction-retrieval; fear response tested 3 h, 12 h, and 12 h with sleep after memory manipulation, and at 24 h; SCR; US expectancy rating after short-term fear test at end of Day 2…”

Section: Studymentioning

confidence: 99%

“…The TV show or video appearing unexpectedly instead of another CS image would be experienced subjectively as the CS+ threat memory making a prediction error. A study by Chen et al [67] (reviewed in Section A.20) describes a transition procedure of this type that leads subjects to regard the 10-min period as being part of the study: "A resting period of 10 min was inserted between reactivation and extinction. During the break, participants watched an excerpt from [the BBC documentary] Planet Earth….During all sessions of the experiment, the shock stimulator was set to the "on" position and the SCR was recorded continuously" (p. 6).…”

Section: Pe and Latent Cause Analysis Of The Retrieval-extinction Protocolmentioning

confidence: 99%

“…Most authors, like Schiller et al [7], indicate only the content of the 10-min period and very little or nothing about the transition. Exceptions are the explicit transition details provided by Junjiao et al [63], Kitamura et al [64], and Chen et al [67] (in Table 1) and Houtekamer et al [79] and Zuccolo and Hunziger [77] (in Table 2). In each of those cases, the transition details can explain why the study produced a replication success or failure.…”

Section: Pe and Latent Cause Analysis Of The Retrieval-extinction Protocolmentioning

confidence: 99%

“…• Annulment of the target emotional memory and its responses takes effect in all studies either immediately after completion of the EIPA or at most after one night's sleep (indicated by one study [67] reviewed in Section A.20).…”

mentioning

confidence: 99%

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Reconsolidation behavioral updating of human emotional memory: A comprehensive review and unified analysis of successes, replication failures, and clinical translation

Ecker¹

2021

Preprint

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The annulment of a human emotional memory through reconsolidation behavioral updating has been documented in over twenty laboratory studies since the first such report in 2010. However, fourteen studies have reported non-replication, the cause(s) of which remain unclear. This review examines all successful and unsuccessful studies in detail, in an attempt to identify (a) the specific probable causes of non-replication and (b) how clinical translation might optimally be designed. For analyzing non-replications, a set of criteria is defined for principled identification of specific moments of prediction error (PE) in experimental procedures, including latent cause transitions, based on a preponderance of empirical evidence. A previously overlooked element of experimental procedure is in that way identified as being potentially decisive, and a unified, testable explanation is proposed for behavioral updating successes and failures in terms of the presence or absence of a PE experience. That in turn allows successful studies to be compared for the internal experiences induced in subjects, rather than compared for their external procedures, revealing an invariant set of three experiences shared by all successful updating studies despite their diverse procedures. Clinical translation, defined as replication of those experiences, not any particular procedure, is illustrated by an actual case, one of many published cases that have documented prompt transformational change produced by that specific methodology, suggesting memory reconsolidation as the mechanism of change. Lastly, the core empirical findings of successful reconsolidation updating studies are compared with previously proposed frameworks of memory reconsolidation in psychotherapy, exposing significant departures from scientific fidelity.

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“…• CS+ fear returns at 3 h but is gone at 24 h, as reported by Chen et al [67] and reviewed in Section A.20;…”

mentioning

confidence: 63%

Section: Studymentioning

confidence: 99%

Section: Pe and Latent Cause Analysis Of The Retrieval-extinction Protocolmentioning

confidence: 99%

Section: Pe and Latent Cause Analysis Of The Retrieval-extinction Protocolmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Reconsolidation behavioral updating of human emotional memory: A comprehensive review and unified analysis of successes, replication failures, and clinical translation

Ecker¹

2021

Preprint

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show abstract

Reconsolidation and Fear Extinction: An Update

Raskin

Monfils

2023

Current Topics in Behavioral Neurosciences

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Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics

Huang,

Liu,

et al. 2024

Neurosci. Bull.

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Retrieval-extinction as a reconsolidation-based treatment for emotional disorders:Evidence from an extinction retention test shortly after intervention

Cited by 13 publications

References 65 publications

Reconsolidation behavioral updating of human emotional memory: A comprehensive review and unified analysis of successes, replication failures, and clinical translation

Reconsolidation behavioral updating of human emotional memory: A comprehensive review and unified analysis of successes, replication failures, and clinical translation

Reconsolidation and Fear Extinction: An Update

Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics

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