2024
DOI: 10.1101/2024.03.20.585950
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Retrieval of an ethanol-conditioned taste aversion promotes GABAergic plasticity in the insular cortex

Lisa R. Taxier,
Meghan E Flanigan,
Harold L. Haun
et al.

Abstract: Blunted sensitivity to ethanol's aversive effects can increase motivation to consume ethanol; yet, the neurobiological circuits responsible for encoding these aversive properties are not fully understood. Plasticity in cells projecting from the insular cortex (IC) to the basolateral amygdala (BLA) is critical for taste aversion learning and retrieval, suggesting this circuit's potential involvement in modulating the aversive properties of ethanol. Here, we tested the hypothesis that GABAergic activity onto IC-… Show more

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