In this paper, we describe the developed methods and technologies, as well as the created research prototype of a ground-space regional monitoring system that was used for comprehensive experimental research of anthropogenic impact on Russian Black sea coastal water areas. Changes in significant water environment parameters (generation of additional spectral components of surface waves; changes in marine surface roughness affecting normalized radar cross-section; turbidity field anomalies affecting spectral brightness variations in various bands of electromagnetic spectrum, etc.) registered in satellite imagery of water areas under anthropogenic impact were revealed. It has been established that these effects were predominantly caused by deep wastewater discharges. Zones of anthropogenic pollution propagations, as well as pipe breakages, have been revealed. The validation of the obtained satellite imagery processing results has been conducted based on sea truth data carried out using buoys, as well as from boats and hydrophysical platform.