Retro-Orbital Granulocytic Sarcoma: Case Report

Marzo, A. Di; Parca, Giampiero; Ingrosso, Gianluca; Giubilei, Cesare; Battista, Michèle; Benassi, M.; Barbarino, Rosaria; Proietti, Federica; Costantini, Sara; Murro, Luana Di; Nicolais, Rebeca; Santarelli, Federico; Santoni, Riccardo

doi:10.1177/030089160809400618

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Granulocytic sarcoma can be diagnosed synchronously with AML, chronic myeloid leukemia (CML), myeloproliferative diseases, and myelodysplastic syndromes, or it may appear during the relapses of these diseases [1]. However, de novo GS is characterized by leukemic tumor formation without bone marrow involvement [2].…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Orbital Granulocytic Sarcoma Without Bone Marrow Involvement: A Report of Two Cases

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et al. 2010

Pediatric Hematology and Oncology

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The authors present herein 2 extramedullary orbital granulocytic sarcoma (GS) cases without bone marrow involvement in view of their rarity and also to reevaluate the treatment approach in this disease. Seven days of high-dose methyl prednisolone (HDMP) treatment (3 days 30 mg/kg/day and 4 days 20 mg/kg/day) was administered initially, and subsequently Acute Myeloid Leukaemia-Berlin Frankfurt Münster (AML-BFM) 2004 treatment protocol was continued for 2 cases. Eye findings of the cases resolved considerably with HDMP treatment. They have still been under systemic chemotherapy without any complication for 1 year. Thus, early diagnosis and AML-targeted intensive chemotherapy improve the prognosis of GS even if there is no bone marrow involvement.

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Section: Discussionmentioning

confidence: 99%

Extramedullary Orbital Granulocytic Sarcoma Without Bone Marrow Involvement: A Report of Two Cases

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et al. 2010

Pediatric Hematology and Oncology

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“…14 If we consider the synovial sarcoma, an X-ray can be a profound technique for clarification of hardening of tissue/deposition of calcium compounds but more advance specific techniques needed to confirm it. 15 Both techniques can be used in routine diagnostics. The risk stratification is always there in case of doubtful cases but better technology leads to better diagnosis.…”

Section: Present Scenario: Diagnostic Paradigmsmentioning

confidence: 99%

Diagnostic dilemma and challenges of granulocytic sarcoma: a review

2021

HTIJ

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The maleficent tumour granulocytic sarcoma is an unusual cancer indite of progressive myeloid precursor cells. It is a Chloroma basically present at an extramedullary location spread through immature granulocytic cells. It can affect any part of the body but the primary site is soft tissues, outside bone marrow, lymph nodes. The root cause may be many factors i.e. genetic, environmental, carcinogens etc. This proliferative type of cancer is sometimes misdiagnosis in contradictory to other acute/chronic tumours. For a histopathologist, it is a challenge for an accurate diagnosis. The tissue biopsy is the known diagnostic technique used since days in cancer diagnosis. To address this review, our main focus is to investigate, analyse the diagnostic limitations or research gaps in granulocytic sarcoma recognition at the clinical level and what can be the possibilities that have developed recently in tumour detection at an early stage. Next, we will try to develop a hypothesis from pinpoint methods used in it as molecular diagnosis, immune-histochemical biomarkers, flow cytometry (FACS) for confirmation of sarcoma so that specificity and sensitivity can be well examined. The prognosis/diagnosis in myeloid tumour detection depends on key factor innovation and medical devices and that should be filled in research and so a gold standard diagnostic kit should be developed.

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“…3,4 There are few reports in the ophthalmic literature of OMS in adults with or without evidence of blood and bone marrow involvement at presentation. [4][5][6][7][8][9] A PubMed search revealed only 20 cases of adult OMS reported over the past 2 decades in the English literature. Exposure keratopathy and associated sensorineural hearing loss are rare presentations and, to the best of our knowledge, have not been reported before in association with OMS.…”

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confidence: 99%