Retrobulbar hemodynamic parameters in open-angle and angle-closure glaucoma patients

Abstract

Purpose The purpose of this study is to compare the retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA), and posterior cilliary arteries (PCA), in open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) patients. Patients and methods A total of 52 eyes from 52 patients with OAG and 25 eyes from 25 ACG patients who met the inclusion/exclusion criteria were included in this cross-sectional study. Peak-systolic velocity, end-diastolic velocity, and Pourcelot resistivity index (RI) were assessed in the OA, CRA, and PCA. Intraocular pressure (IOP) was measured both with the Goldmann applanation tonometer (GAT) and with the Dynamic Contour tonometer (DCT) three times, respectively. Ocular pulse amplitude was measured using DCT. Results The RI was significantly higher in both the ophthalmic and short PCA in the OAG patients as compared with that in those ACG patients, P ¼ 0.003 and 0.048, respectively. There was no correlation between the IOP measured with GAT and the retrobulbar hemodynamic parameters in either OAG or ACG. Conclusions There was an increased resistance to blood flow in the OA of OAG as compared with ACG patients. Additionally, the degree of circulatory disturbance was not related to either the IOP or the visual-field damage.

Optical Coherence Tomography Angiography Macular and Peripapillary Vessel Perfusion Density in Healthy Subjects, Glaucoma Suspects, and Glaucoma Patients

“…Chronic impairment of ocular blood flow with subsequent ischemia-reperfusion damage has been advocated as a major pathogenic factor. 23 Several instruments have been applied to inquire into ocular blood flow in glaucoma, including fluorescein and indocyanine green angiography, 24 laser speckle flowgraphy, 25 color Doppler imaging, 26 Doppler OCT, 27 confocal scanning laser Doppler flowmetry, 28 and retinal functional imager. 29 Although welcomed with great enthusiasm, none of these eventually broke Data are reported for controls (C), glaucoma suspects (GS), and glaucoma (G).…”

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma

“…This result can be explained by the different pathogenic mechanisms of these two conditions. 13,23 PACG is characterized by uncontrolled IOP due to the mechanical obstruction of aqueous outflow, caused by the contact of the peripheral iris and the trabecular meshwork. On the other hand, although IOP is considered to be among the main risk factors for POAG, other factors may contribute to glaucomatous damage in POAG, especially in Asian populations where normal-tension glaucoma predominates.…”

“…12 However, PACG is a disease entity that differs from POAG in terms of the clinical course and pathogenic mechanisms. 13 Higher IOP elevation is observed in PACG, and causes ischemic injury to various intraocular structures, for instance, the lens, corneal endothelium, and iris. Likewise, ocular perfusion can also be altered during the process of IOP elevation, which may directly cause deterioration in the peripapillary and macular microvascular perfusion.…”

Effect of Single Intravitreal Bevacizumab on Ophthalmic and Middle Cerebral Arterial Blood Flow in Retinopathy of Prematurity

“…It was stated that RI provides important information regarding the status of blood circulation [26]. Besides, it has been shown that decreased blood flow velocities accompany the increased RI [13].…”