Retrobulbar Neuritis following Rabies Vaccination

Bilateral neuro-retinitis following chick embryo cell anti-rabies vaccination – a case report

“…Apart from this, no published reports are available regarding the neurological complication following purified chick embryo cell vaccination (although manufacturer's information on their websites does mention the risk of neurological complications with some chick embryo vaccines). This case was also unusual in the sense that patient has neuroretinits as compared to previously reported cases which have retrobulbar neuritis or papillitis [6-11]. Although good recovery is reported spontaneously, pulse steroids speed up the recovery.…”

“…We report the case of a 56 year old male who developed bilateral neuro-retinitis following three injections of antirabies vaccine prepared from the chick embryo. Retrobular neuritis and papillitis following sheep brain antirabies vaccine have been reported [6-11]. The present report describes a case with bilateral neuroretinitis after chick embryo antirabies vaccine, which to best of our knowledge has not been reported earlier.…”

A review of orbital and intracranial magnetic resonance imaging in 79 canine and 13 feline patients (2004–2010)

“…Optic neuritis may occur secondary to granulomatous meningoencephalitis (GME), necrotizing leukoencephalitis/meningoencephalitis, infectious encephalomyelitis (viral, bacterial, fungal, rickettsial, protozoal, and parasitic), toxic or neoplastic processes 5,71–85 . The most commonly reported cause of ON in dogs is GME 5,86–88 .…”

Neuroretinitis after the second injection of a SARS-CoV-2-vaccine: A case report

“…10 Flu vaccination has also been reported to be associated with numerous ophthalmic adverse effects; in addition to uveitis, 10 multiple evanescent white dot syndrome 14 and a variety of types of inflammation involving the optic nerve, including optic nerve head inflammation, 15 retrobulbar optic nerve inflammation, 16 and acute macular neuroretinopathy 17 have been documented. Optic neuritis has also been reported to be associated with administration of the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap)-inactivated polio vaccine, 18 hepatitis A virus (HAV) vaccine and typhoid fever vaccine, 19 measles vaccine, 20 anti-rabies vaccine, 21 , 22 Tdap vaccine, 23 and varicella-zoster virus vaccine. 24 Although the exact mechanism is unknown, vaccine-induced optic neuritis is believed to occur because the T-cells activated by vaccines cross the blood-brain barrier, resulting in type IV hypersensitivity.…”