Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study

Comer, Garet C.; Smith, Micah W.; Hurwitz, Eric L.; Mitsunaga, Kyle A.; Kessler, Robert; Carragee, Eugene J.

doi:10.1016/j.spinee.2012.09.040

Cited by 107 publications

(66 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ProDisc ® (Synthes, West Chester, PA) lumbar total disc replacement (TDR) trial reported an incidence of 1.2% (1/82) in males undergoing TDR [11] , while the Charité™ (DePuy, Raynham, MA) artificial disc trial reported an incidence of 4% (6/147) in males undergoing either TDR or anterior fusion [12] . A recent retrospective consecutive cohort study implicates the inflammatory reaction associated with recombinant human bone morphogenetic protein-2 (rhBMP-2) use as an adjunct to anterior lumbar interbody fusion (ALIF) at L5-S1 in generating an increased incidence of retrograde ejaculation [13] . A 6.3% incidence (15/239) of retrograde ejaculation was identified in male patients receiving rh-BMP-2 as an adjunct to one (L5-S1) or two (L4-5/L5-S1) level ALIF, as compared to an incidence of 0.9% (2/233) absent rhBMP-2 use in the control arm.…”

Section: Retrograde Ejaculationmentioning

confidence: 99%

Access related complications during anterior exposure of the lumbar spine

Fantini

Pawar²

2013

WJO

View full text Add to dashboard Cite

The new millennium has witnessed the emergence of minimally invasive, non-posterior based surgery of the lumbar spine, in particular via lateral based methodologies to discectomy and fusion. In contrast, and perhaps for a variety of reasons, anterior motion preservation (non-fusion) technologies are playing a comparatively lesser, though incompletely defined, role at present. Lateral based motion preservation technologies await definition of their eventual role in the armamentarium of minimally invasive surgical therapies of the lumbar spine. While injury to the major vascular structures remains the most serious and feared complication of the anterior approach, this occurrence has been nearly eliminated by the use of lateral based approaches for discectomy and fusion cephalad to L5-S1. Whether anterior or lateral based, non-posterior approaches to the lumbar spine share certain access related pitfalls and complications, including damage to the urologic and neurologic structures, as well as gastrointestinal and abdominal wall issues. This review will focus on the recognition, management and prevention of these anterior and lateral access related complications. INTRODUCTIONAnterior spinal access is often required for the treatment of spinal deformity, bony and/or discogenic infection, trauma, tumor and degenerative disease. Advantages of this approach include performance of a thorough discectomy and release, capability to implant high profile interbody fusion and non-fusion devices, debridement and excision of necrotic tissue, removal of migrated/ misplaced devices, and a favorable milieu for interbody fusion with rich blood supply and graft/device placement under compression. The most common associated complications include damage to the vascular, urologic and neurologic structures, as well as gastrointestinal and abdominal wall issues. VASCULAR INJURYAnterior exposure of the spine at the L4-L5 and L5-S1 levels requires mobilization of the left common iliac vessels, as they course obliquely across the anterior aspect of the L5 body, traversing variable portions of the L4-L5 and L5-S1 disc spaces in the process. The most dorsally located, the left common iliac vein is the most likely vascular structure to be injured during anterior lumbar spinal surgery. Apart from intraoperative hemorrhage and the challenge associated with vascular control and repair, TOPIC HIGHLIGHTthrombotic occlusion may occur in the postoperative period following seemingly uncomplicated iliac venorrhaphy, or simply as a result of prolonged retraction of the iliac vein or inferior vena cava. The ascending iliolumbar vein acts as an important dorsolateral tether to the left common iliac vein, therefore routine ligation and division will facilitate anterior exposure of the L4-L5 disc space [1] . Similarly, ligation and division of the L4 segmental vessels will release the aortic terminus and the terminal inferior vena cava (IVC), thus permitting retraction to the right side of the spine, further facilitating anterior exposure of the L4...

show abstract

Section: Retrograde Ejaculationmentioning

confidence: 99%

Access related complications during anterior exposure of the lumbar spine

Fantini

Pawar²

2013

WJO

View full text Add to dashboard Cite

show abstract

“…Vertebral and nonvertebral bone resorption 41,48,55,60,61,156,[164][165][166][167][168][169][170] Graft subsidence 41,60,61,166,171 Urogenital events Retrograde ejaculation 76,[172][173][174][175] Bladder retention 172,175 Wound complications Hematoma No competing financial interests exist.…”

mentioning

confidence: 99%

A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2

James

LaChaud

Shen

et al. 2016

Tissue Engineering Part B: Reviews

850

769

View full text Add to dashboard Cite

Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration (FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with increasing clinical use of BMP-2, a growing and well-documented side effect profile has emerged. This includes postoperative inflammation and associated adverse effects, ectopic bone formation, osteoclast-mediated bone resorption, and inappropriate adipogenesis. Several large-scale studies have confirmed the relative frequency of adverse events associated with the clinical use of BMP-2, including life-threatening cervical spine swelling. In fact, the FDA has issued a warning of the potential life-threatening complications of BMP-2. This review summarizes the known adverse effects of BMP-2, including controversial areas such as tumorigenesis. Next, select animal models that replicate BMP-2's adverse clinical effects are discussed. Finally, potential molecules to mitigate the adverse effects of BMP-2 are reviewed. In summary, BMP-2 is a potent osteoinductive cytokine that has indeed revolutionized the bone graft substitute market; however, it simultaneously has accrued a worrisome side effect profile. Better understanding of these adverse effects among both translational scientists and clinicians will help determine the most appropriate and safe use of BMP-2 in the clinical setting.

show abstract

“…The risk of injury to the superior hypogastric plexus, which in men results in retrograde ejaculation, is reported to be less than 3% (10,46). Retrograde ejaculation is less frequently observed with L4/5 approaches than L5/S1 and also, the incidence is significantly reduced with a retroperitoneal approach compared to a transperitoneal approach (47,48). In contrast to the ALIF studies, retrograde ejaculation in men has not been yet reported for XLIF (31).…”

Section: Complicationsmentioning

confidence: 95%

Comparison of ALIF vs. XLIF for L4/5 interbody fusion: pros, cons, and literature review

Winder¹,

Gambhir²

2016

J. Spine Surg.

View full text Add to dashboard Cite

The incidence of lumbar fusion for the treatment of various degenerative lumbar spine diseases has increased dramatically over the last twenty years. Many lumbar fusion techniques have been developed and popularized, each with its own advantages and disadvantages. Anterior lumbar interbody fusion (ALIF) initially introduced in the 1930's, has become a common and widely accepted technique for lumbar fusions over the last decade offering several advantages over standard posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion (TLIF). More recently, the lateral trans-psoas approach termed extreme, direct or lateral lumbar interbody fusion (XLIF, DLIF, LLIF) is gaining widespread popularity.The aim of this paper is to compare the approaches, advantages and disadvantages of ALIF and XLIF for L4/5 interbody fusion based on relevant literature.

show abstract

Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study

Cited by 107 publications

References 38 publications

Access related complications during anterior exposure of the lumbar spine

Access related complications during anterior exposure of the lumbar spine

A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2

Comparison of ALIF vs. XLIF for L4/5 interbody fusion: pros, cons, and literature review

Contact Info

Product

Resources

About