Retrolental Fibroplasia : Early Development and the Effect of ACTH in Treatment

Brown, Christine; Corner, Beryl D.

doi:10.1136/bjo.36.6.281

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…It has been shown that infants treated with adenocorticotropic hormone have lower incidence of ROP [7,8] and thoughts have been raised that inflammation could be one risk factor for development of this disease, which also has been supported by recent research [9][10][11] . It has been shown that angiogenesis is associated with inflammation and the inflammatory cytokines TNF-␣ , IL-1 and IL-18 have been emphasized in inflammation-associated angiogenesis [12][13][14][15][16] .…”

mentioning

confidence: 90%

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Hellgren

Willett²,

Engström³

et al. 2010

Neonatology

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Background: Extremely preterm delivery is, amongst other complications, associated with retinopathy of prematurity (ROP). Untreated, ROP can progress to visual impairment and blindness due to an overgrowth of new vessels in the retina and vitreous cavity. Objective: The aim of this study was to identify cytokine markers within the first weeks of life that could be used to predict the risk for development of ROP later in life. Methods: Serum levels of 27 different cytokines in infants born at gestational weeks 23–30 were analyzed using a multiplex immunoassay method and compared between infants who did not develop ROP and infants who later developed proliferative ROP. In addition, mRNA levels of brain-derived neurotrophic factor (BDNF) in retinas from mice exposed to hyperoxia were analyzed using quantitative real-time PCR. Results: At birth, serum levels of IL-5 were higher in infants with no ROP compared to infants with proliferative ROP. 10–14 days after birth, serum levels of BDNF and RANTES were lower in infants who later developed proliferative ROP compared to infants who did not develop ROP. Furthermore, mRNA expression levels of BDNF in retinas from mice exposed to hyperoxia were significantly lower at postnatal day 15 compared to retinas from mice in room air. Conclusions: These results indicate that BDNF and RANTES may be important factors in the selective vulnerability of ROP development in preterm infants.

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confidence: 90%

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Hellgren

Willett²,

Engström³

et al. 2010

Neonatology

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“…The hypothesis of an inflammatory response as a risk factor for ROP is supported by data showing that infants treated with adenocorticotropic hormone (ACTH), which suppresses inflammation, have a lower incidence of ROP [16,17], and the inflammatory cytokines TNF-α, IL-1, and IL-8 are associated with inflammatory-mediated angiogenesis [18–22]. Inhibition of TNF-α improves physiological angiogenesis and reduces pathological neovascularization in oxygen-induced retinopathy in mice [23,24].…”

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confidence: 99%

Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity

Hellgren

Löfqvist

Hansen‐Pupp

et al. 2018

Growth Hormone & IGF Research

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Objective Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24 h after birth, and then weekly until at least 36 weeks postmenstrual age (PMA) (i.e., up to 13 weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. Results IL-6 levels negatively correlated with IGF-I levels between 5 and 8 weeks after birth, (p < 0.01 to p < 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p < 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. Conclusions The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.

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