Retrolental fibroplasia

Hepner, Ray; Fletcher, Mary C.; Desmond, Murdina M.; Hunt, Harold S.; Brandon, Sylvan

doi:10.1016/s0022-3476(56)80114-5

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Light and Rop1

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1962

1997

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Cited by 3 publications

(2 citation statements)

References 6 publications

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“…In addition, the racial composition of the study population was not the same in each of the 23 Accepted for publication November 13, 1996. This study was supported by Cooperative Agreement …”

mentioning

confidence: 99%

Racial Variation in Retinopathy of Prematurity

Saunders

Donahue²,

Christmann³

et al. 1997

Arch Ophthalmol

142

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mentioning

confidence: 99%

Racial Variation in Retinopathy of Prematurity

Saunders

Donahue²,

Christmann³

et al. 1997

Arch Ophthalmol

142

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“…Early studies which followed indicated that patching the eyes from birth to discharge did not reduce the incidence of RLF [20,21], leading to the conclusion that light was not a factor. However, the conditions were quite different from today's nursery.…”

Section: Light and Ropmentioning

confidence: 99%

Light and the developing retina

Glass

1990

Doc Ophthalmol

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Retinopathy of prematurity (ROP) has increased in the United States in the past decade. Its resurgence has been attributed to advances in medical care which have increased the survival of infants less than 1000 g. Retinal immaturity and exposure to supplementary oxygen are generally accepted as the principal factors associated with ROP, however precocious exposure of the immature retina to light may also contribute. The preterm infant is routinely exposed for the duration of hospital stay to bright continuous light at levels which produce retinal damage in animals. A recent study has provided evidence implicating light in ROP. Preterm infants for whom the light levels were reduced had a lower incidence of ROP, compared to a similar group of preterms exposed to standard levels of nursery light. Given the problems of a non-randomized design, the results must be considered preliminary; however the findings are substantiated by parallel results in both hospitals studied and by an effect of exposure to light within the treatment group. Speculations regarding the mechanisms of light as a contributor to ROP include: alterations of retinal metabolism, cellular damage by phototoxicity, and the generation of free radicals. Mechanisms of phototoxicity are compatible with theories of oxygen toxicity. Light may not be necessary for ROP to occur, but it may increase the risk.

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Die retrolentale Fibroplasie

Rohrschneider¹,

Meister²

1962

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

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Retrolental fibroplasia

Cited by 3 publications

References 6 publications

Racial Variation in Retinopathy of Prematurity

Racial Variation in Retinopathy of Prematurity

Light and the developing retina

Die retrolentale Fibroplasie

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