Retroorbital Hemangiopericytoma and Cavernous Sinus Schwannoma. Case Report.

Goel, Atul; Muzumdar, Dattatraya; Desai, Ketan; Chagla, Aadil

doi:10.2176/nmc.43.47

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…FA and DV have long been appreciated by ophthalmologists, who have observed them as vessels that supply and drain retinal tumors. [47][48][49] However, FA and DV are by no means exclusive to the eye and have been found in all tumors that have been appropriately examined.…”

Section: Arterio-venogenesis: the Formation Of Feeder Arteries And Drmentioning

confidence: 99%

Heterogeneity of the Tumor Vasculature

Nagy¹,

Chang²,

Shih³

et al. 2010

Semin Thromb Hemost

350

266

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The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form. Four of the six vessel types (mother vessels, capillaries, glomeruloid microvascular proliferations, and vascular malformations) develop from preexisting normal venules and capillaries by angiogenesis. The two remaining vessel types (feeder arteries and draining veins) develop from arterio-venogenesis, a parallel, poorly understood process that involves the remodeling of preexisting arteries and veins. All six of these tumor vessel types can be induced to form sequentially in normal mouse tissues by an adenoviral vector expressing vascular endothelial growth factor (VEGF)-A164. Current antiangiogenic cancer therapies directed at VEGF-A or its receptors have been of only limited benefit to cancer patients, perhaps because they target only the endothelial cells of the tumor blood vessel subset that requires exogenous VEGF-A for maintenance. A goal of future work is to identify therapeutic targets on tumor blood vessel endothelial cells that have lost this requirement.

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Section: Arterio-venogenesis: the Formation Of Feeder Arteries And Drmentioning

confidence: 99%

Heterogeneity of the Tumor Vasculature

Nagy¹,

Chang²,

Shih³

et al. 2010

Semin Thromb Hemost

350

266

View full text Add to dashboard Cite

show abstract

“…2 Many cases of orbital hemangiopericytoma have been reported in the literature along with various surgical approaches, long-term outcomes, and techniques to manage recurrence; however, few have discussed preoperative embolization. 1,3-5 Intraoperative hemorrhage is a concern in both the congenital and the adult form of these cases 6,7 and may be an indication for preoperative embolization. A unique case of preoperative embolization was presented with n-butyl cyanoacrylate for surgical resection of a large orbital hemangiopericytoma in a 58-year-old woman.…”

mentioning

confidence: 99%

Endovascular Preoperative Embolization of Orbital Hemangiopericytoma With n-Butyl Cyanoacrylate Glue

Wallace

Alaraj

Aakalu

et al. 2014

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Hemangiopericytoma is an uncommon neoplasm that may present in myriad locations, including the lower extremities, pelvic area, and the head and neck area, including the orbit.1 Orbital hemangiopericytoma is often described as synonymous with orbital solitary fibrous tumor, giant cell angiofibroma, and fibrous histiocytoma, as they all belong to a spectrum of collagen-rich fibroblastic tumors that are often CD34-positive and have overlapping histopathologic features.2 Many cases of orbital hemangiopericytoma have been reported in the literature along with various surgical approaches, long-term outcomes, and techniques to manage recurrence; however, few have discussed preoperative embolization.1,3-5 Intraoperative hemorrhage is a concern in both the congenital and the adult form of these cases6,7 and may be an indication for preoperative embolization. A unique case of preoperative embolization was presented with n-butyl cyanoacrylate for surgical resection of a large orbital hemangiopericytoma in a 58-year-old woman.

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“…30 Another case report of an extraconal orbital hemangiopericytoma mentions treatment with endovascular glue embolization of the feeder vessels, followed by surgical resection. 31 The patient had no light perception preoperatively, and the ophthalmic artery was embolized. In another case of a congenital orbital hemangiopericytoma, biopsy resulted in life-threatening hemorrhage, which was controlled with an external carotid artery ligation.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Embolization of an Orbital Hemangiopericytoma With Onyx Facilitates Its Surgical Excision

Pihlblad¹,

Schaefer²

2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

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This is a case report on the surgical treatment of orbital hemangiopericytoma. The patient initially underwent an attempted excision of the tumor with significant hemorrhage elsewhere, which precluded its complete excision. Due to continued growth and pain, the patient underwent percutaneous embolization with Onyx-18 under fluoroscopic radiographic guidance. The patient continued to have pain, progressive enlargement of the tumor, and underwent surgical excision. The excision was noted to have minimal bleeding and was relatively easy to dissect and excise compared with the typical hemangiopericytoma. Embolization with Onyx-18 may be a useful preoperative treatment option for hemangiopericytomas and other vascular lesions of the orbit, and elsewhere.

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Retroorbital Hemangiopericytoma and Cavernous Sinus Schwannoma. Case Report.

Cited by 11 publications

References 6 publications

Heterogeneity of the Tumor Vasculature

Heterogeneity of the Tumor Vasculature

Endovascular Preoperative Embolization of Orbital Hemangiopericytoma With n-Butyl Cyanoacrylate Glue

Percutaneous Embolization of an Orbital Hemangiopericytoma With Onyx Facilitates Its Surgical Excision

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