Retroperitoneal dedifferentiated liposarcoma: Analysis of 61 cases from a large institution

Luo, Peng; Cai, Weiluo; Yang, Lingge; Wu, Zhiqiang; Chen, Yong; Zhang, Ruming; Yan, Wangjun; Shi, Yingqiang; Wang, Chunmeng

doi:10.7150/jca.25715

Cited by 21 publications

(17 citation statements)

References 24 publications

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“…The is no consensus regarding the efficacy of radiotherapy and chemotherapy for retroperitoneal liposarcoma. Analysis of 61 cases of retroperitoneal liposarcoma at a large institution showed that response rates to radio-and chemotherapy are low, even with doxorubicin being the first-line chemotherapy for metastatic and or unresectable disease (48). Chemotherapy and radiotherapy are ineffective for the majority of PRPLS cases, with a chemotherapy response rate of <10% (49,50).…”

Section: Discussionmentioning

confidence: 99%

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

et al. 2021

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Background: Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue sarcoma of the retroperitoneum with high recurrence rate and short overall survival (OS).Methods: A retrospective review of 51 patients with PRPLS, treated between September 1, 2009 and November 30, 2020, was conducted to evaluate clinical outcomes of PRPLS resection. Patient demographics, histopathologic subtypes, overall survival (OS), progression-free survival (PFS), disease recurrence rate, and tumor stage were reviewed and analyzed. Univariate analysis was done to identify factors potentially affecting OS and PFS of PRPLS patients. Multivariate Cox proportional hazards analysis was used to evaluate the impact of various clinicopathological factors on OS and PFS of PRPLS patients.Results: Fifty-one PRPLS patients (28 Males, 23 Females; mean age 56.25 years) were evaluated. There was no significant effect of age, gender, contiguous organ resection, degree of differentiation and tumor size on the OS and PFS of the patients. Univariate analysis showed that negative surgical margin and early tumor stage significantly correlated with OS and PFS (all P < 0.001). Multivariate analysis showed that tumor stage [hazard ratio (HR) = 1.177, P = 0.001] was an independent predictors of poor progression-free survival, and surgical margins [HR = 4.0674 P = 0.038] and tumor stage [HR = 1.167 P = 0.001] were identified as independent predictors of poor overall survival.Conclusion: Negative surgical margin is a prognostic factor of OS, and can prolong the postoperative survival time of PRPLS patients. Tumor stage is a prognostic factor for OS and PFS, and can influence the survival of PRPLS patients. Earlier tumor stages of PRPLS are associated with significantly better outcomes.

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Section: Discussionmentioning

confidence: 99%

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

et al. 2021

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“…Lehnert et al retrospectively analyzed 110 RSTS patients and found that intraoperative bleeding >1,500 mL was an independent risk factor for poor postoperative survival (13). Luo et al found that amongst retroperitoneal dedifferentiated liposarcoma (RP DDLPS) patients, higher levels of intraoperative bleeding predicted a poor survival prognosis [hazard ratio (HR) 3.302, 95% CI: 1.231-8.858, P=0.018] (14). In our study, univariate analysis revealed that intraoperative bleeding <1,500 mL indicated better OS and PFS, but the effect of multivariate analysis was not significant in PR RPLPS.…”

Section: Discussionmentioning

confidence: 99%

Resection outcomes for primary and local recurrent retroperitoneal liposarcoma patients

Yang¹,

Xia²,

Teng³

et al. 2020

Ann Transl Med

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Background: The clinical characteristics of primary retroperitoneal liposarcoma (PR RPLPS) and local recurrent retroperitoneal liposarcoma (LR RPLPS) cases were compared to determine the related factors involved in postoperative survival.Methods: A total of 90 patients who underwent surgery between 2006 and 2013 were included in this study.Clinicopathological data that was prospectively gathered was analyzed to identify factors associated with overall survival (OS) and progression-free survival (PFS).Results: The PR cases showed a higher complete resection rate when compared to the LR group. The LR group showed a greater number that were poorly differentiated and highly malignant. More blood loss was observed in the LR compared to the PR group. Multivariate analysis suggested that blood loss and tumor grade were prognostic factors for OS and PFS of the PR group, but extent of resection was a prognostic factor only for OS. In the LR group, the extent of resection was a significant prognostic factor associated with OS, whereas tumor grade was associated with PFS.Conclusions: Complete surgical resection is the most important factor for the survival of RPLPS patients.Tumor grade is an independent prognostic factor for PFS. In PR RPLPS, poor tumor classification and increased intraoperative bleeding are associated with a poor prognosis.

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“…Although surgical resection of WDL and DDL remains the first choice, it remains an unsuitable option for patients with unresectable, unstable and metastatic disease, especially in those with large liposarcomas due to poor outcomes. It is clear there is much development to be made in this area, and until then prognosis remains poor with almost 50% of patients eventually dying with the disease [ 21 ]. In the meantime, an MDT approach to diagnosis and management is vital to providing the best outcome possible for such patients with this rare diagnosis.…”

Section: Discussionmentioning

confidence: 99%