Retroperitoneal Ganglioneuroma (GN): Case report in 14 years old boy

Arab, Nahlah; Alharbi, Ashwag

doi:10.1016/j.ijscr.2019.06.011

Cited by 9 publications

(12 citation statements)

References 7 publications

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“…Most retroperitoneal GNs are asymptomatic and nonfunctional, so they are mainly found incidentally by health examination or other disease complications (14), which agrees with our findings that nearly 66% of the cases did not have specific symptoms. However, patients can present with some nonspecific symptoms related to tumor-mass effects, for instance, abdominal pain and vomiting from compressing digestive organs, backache and scoliosis due to spinal deformity, dyspnea because of diaphragm muscle compression, as well as gait abnormality, weakness, and paresthesia owing to spinal cord compression (11,17,18). Among our cases, eight patients had abdominal pain and one patient had hand numbness and neck pain, which were in accordance with the tumor locations and sizes and can be explained by the mass effects.…”

Section: Discussionmentioning

confidence: 99%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

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Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.

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Section: Discussionmentioning

confidence: 99%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

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“…It can also come from the maturation of pre-existent neuroblastoma spontaneously or after chemotherapy [ 5 ]. It is composed of gangliocytes and mature stroma [ 6 ]. This tumor can grow at any site of the sympathetic nervous tissue and it is mainly distributed in the posterior mediastinum, retroperitoneum, neck and adrenal gland in descending order [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal ganglioneuroma presenting as an obstructive pyelonephritis: a case report

Kora

Amar

Arabi

et al. 2021

Journal of Surgical Case Reports

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Ganglioneuroma is a nerve tumor arising from the sympathetic neural crest. It is a rare benign tumor. Retroperitoneum is its second location after the posterior mediastinum. Usually asymptomatic, it is discovered incidentally on imaging. Surgical resection is the sole treatment. The prognosis is good if the diagnosis is made early with quality R0 surgical excision. We report a case in a 14-year-old female admitted to the emergency department for obstructive pyelonephritis. Imaging features found a retroperitoneal mass with characteristics suggestive of a retroperitoneal ganglioneuroma, which was confirmed by histological study. Ganglioneuroma should be a part of differential diagnoses for any retroperitoneal mass in children and young adults.

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“…Extra-adrenal retroperitoneal ganglioneuromas in pediatric population are very rare. Our literature survey (PubMed/MEDLINE, Scopus, and Web of Science) revealed a few reported cases and small case series (1,4,7,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) with very few cases reported in the patients <10 years (summarized in Table 1). Scherer et al (2001) reported the largest case series of 5 patients (4 patients under the age of 10) depicting the radiological (CT and MRI) features of retroperitoneal GNs.…”

Section: Fig 3a-b Hematoxylin and Eosin (Hande) Slides Of The Moderately Cellular Neoplasm At Low Power (40´) Magnification (A); The Tumomentioning

confidence: 98%

“…The optimal treatment approach for most patients with retroperitoneal GN is a complete surgical excision (7). However, this approach has certain limitations, particularly in the case in which the large GN surrounds and compresses large blood vessels making its dissection extremely difficult.…”

Section: Fig 3a-b Hematoxylin and Eosin (Hande) Slides Of The Moderately Cellular Neoplasm At Low Power (40´) Magnification (A); The Tumomentioning

confidence: 99%

“…Although the diagnosis of GN cannot be reliably established on radiological findings alone, magnetic resonance imaging (MRI) and computed tomography (CT) scanning are the preferred imaging methods to assess these tumors (6). A complete surgical removal is the treatment of choice whenever possible and it usually gives an excellent outcome (7). Unlike smaller GNs that are commonly diagnosed in childhood, large GNs tumors are mainly diagnosed after the age of ten.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Extra-adrenal Retroperitoneal Ganglioneuroma in a 9-year-old Female: A New Case Report with a Comprehensive Literature Review

et al. 2020

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Objective -We present herein a new case and survey comprehensively literature on this rare condition. Case report -A 9-yearold girl with a medical history of surgical correction of clubfoot three months earlier presented to our department with an incidentally detected abdominal mass during diagnostic workup for orthopedic surgery. A CT scan revealed a solid right extra-adrenal mass measuring 7×6 cm. It was compressing/involving the infrahepatic part of inferior vena cava, right renal vein and artery with an incomplete encasing of the abdominal aorta. The surgery was successfully performed. The histopathological analysis confirmed GN. Conclusions -Although pediatric extra-adrenal retroperitoneal ganglioneuroma (GN) are rare, their propensity for enveloping major blood vessels is not. GNs should be considered in the differential diagnosis of any circumscribed retroperitoneal mass. These tumors can be successfully treated with surgery that leads to an excellent outcome, even in case of incomplete resections with tumor residuals <2 cm.

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Retroperitoneal Ganglioneuroma (GN): Case report in 14 years old boy

Abstract: Highlights Ganglioneuroma (GN) is a rare benign tumor. GN are usually asymptomatic found incidentally on abdominal imaging or having nonspecific symptoms related to mass effect. The cornerstone for the management its remain on complete surgical excision.

Cited by 9 publications

References 7 publications

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Retroperitoneal ganglioneuroma presenting as an obstructive pyelonephritis: a case report

A Case of Extra-adrenal Retroperitoneal Ganglioneuroma in a 9-year-old Female: A New Case Report with a Comprehensive Literature Review

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