Retroperitoneal ganglioneuroma in children: CT and MRI features with histologic correlation

Cai, Jinhua; Zeng, Yan; Zheng, Hongliang; Qin, Yong; Kaiyong, T; Zhao, Jun

doi:10.1016/j.ejrad.2010.05.040

Cited by 37 publications

(48 citation statements)

References 15 publications

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“…When ganglion cells and nerve fibres increase, CT reveals increased density, while T 2 weighted imaging shows slightly hyperintense signals. Heterogeneous hypointense signals in lesions on T 2 weighted imaging correspond to ganglion cells and nerve fibres [5]. In the current study, plain CT revealed hypodensity in 16 lesions.…”

Section: Discussionmentioning

confidence: 79%

“…CT value at 120 s was 10-20 HU with an average of 13.6 HU. Studies demonstrate that thoracic ganglioneuroma has imaging characteristics similar to abdominal ganglioneuroma [1][2][3][4][5][6], which may aid accurate diagnosis of ganglioneuroma over the body.…”

Section: Discussionmentioning

confidence: 99%

“…It often occurs in the retroperitoneal space and posterior mediastinum [1][2][3]. Though abdominal ganglioneuroma is often summarised in the literature [3][4][5][6][7], thoracic ganglioneuroma is sporadic and rarely reported [8][9][10][11][12][13]. Because there is a lack of knowledge about thoracic ganglioneuroma, preoperative misdiagnosis often occurs in clinical practice.…”

mentioning

confidence: 99%

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CT and MRI findings of thoracic ganglioneuroma

Guan

Zhang²,

Zeng³

et al. 2012

The British Journal of Radiology

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Objective: Thoracic ganglioneuroma is sporadic and rarely reported. Pre-operative misdiagnosis often occurs in clinical practice. To improve diagnostic accuracy and facilitate differential diagnosis, we summarised the CT and MRI findings of thoracic ganglioneuroma. Methods: 22 cases of thoracic ganglioneuroma confirmed by surgery and pathology were retrospectively analysed in terms of CT (16 cases) and MRI data (6 cases). Results: Of 22 lesions, 19 occurred in the posterior mediastinum, 2 in the lateral pleura and 1 in the right chest. The CT value of the plain scans ranged from 20 to 40 HU (mean 29.1 HU) in 16 cases. Punctate calcification was noted in four cases. Patchy fat density shadow was found in one case. Arterial-phase CT found nearly no enhancement (6 cases) or slight enhancement (10 cases) with a CT value of 0-12 HU (mean 5.8 HU). In the delayed phase, enhancement was strengthened progressively, and CT value of 10-20 HU (mean 13.6 HU) was achieved after 120 s. T 1 weighted images showed homogeneous hypointense signals in five cases and hypointense signals mixed with patchy hyperintense signal shadow in one case. T 2 weighted images demonstrated heterogeneous hyperintense signals in all six cases, of which the whorled appearance was noted in one case. Gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced MRI found mildly heterogeneous enhancement in the arterial phase, and progressive mild enhancement in the delayed phase. Conclusion: Thoracic ganglioneuroma shows hypodensity in plain CT. On CT and MRI, non-enhancement or slight enhancement in artery phase and progressive mild enhancement in delay phase are characteristic manifestations of ganglioneuroma in the thorax.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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CT and MRI findings of thoracic ganglioneuroma

Guan

Zhang²,

Zeng³

et al. 2012

The British Journal of Radiology

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“…In a series of ganglioneuromas by Cai et al, some ganglioneuromas tended to extend to intervessel space without encasing them. This was interpreted as an important imaging manifestation reflecting the soft and benign biological behaviour of these lesions [1].…”

Section: Discussionmentioning

confidence: 99%

“…Ganglioneuromas are commonly asymptomatic, and the development of clinical symptoms depend on the localisation and the size of the tumour. Additionally, because of the malignant transformation of a small number of ganglioneuromas reported in the literature, early diagnosis and complete excision of the tumour is essentially important [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic imaging findings of pelvic retroperitoneal ganglioneuroma in a child: a case report with the emphasis on initial ultrasound findings

Demir

et al. 2016

Med Ultrason

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Ganglioneuromas are rare benign tumors of neural crest origin developed along the sympathetic chain. The pelvic retroperitoneum is the rarest location of these tumors. Clinically these tumors are commonly asypmtomatic even if they reach large sizes. Here we report the radiological features of a 16 year old boy with pathologically proven retroperitoneal ganglioneuroma that was detected initially by ultrasound. Relevant literature is also discussed.

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