Retroperitoneal Schwannoma: A Rare Case

Kalaycı, Murat; Akyüz, Ümit; Demi̇rağ, A; Gürses, Bengı; Özkan, Ferda; Gökçe, Özcan

doi:10.1155/2011/465062

Cited by 21 publications

(41 citation statements)

References 4 publications

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“…Percentage of patients with schwannoma and Von Recklinghausen's disease is 5-18%. In this case, malignancy is more frequent [1,5,6]. None of the stigmata of this disease was present in our cases.…”

Section: Discussionmentioning

confidence: 45%

“…Schwannomas represent < 1% of all adrenal incidentalomas [1,10]. The most important difference between adrenal schwannomas and retroperitoneal schwannomas is that the retroperitoneal schwannomas can undergo malignant transformation with poor prognostic [5]. We present the case of a middle-aged female diagnosed of adrenal schwannoma.…”

Section: Discussionmentioning

confidence: 97%

“…They have homogeneous or heterogeneous appearance with areas of cystic degeneration (61-66% of cases) and calcifications (23% of cases) or hemorrhage at CT [2][3][4][5][6][7]. When CT showed a heterogeneous lesion, the tumor can mimic pheochromocytoma or other malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

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Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Fernández

Villamil

Fernández-Pello

et al. 2016

World J Nephrol Urol

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Schwannoma is a rare slow-growing neurogenic tumor of the nerve sheath origin. They are commonly seen in middle-aged with a female to male ratio of 1:1.2. Here we present three cases of retroperitoneal schwannoma in our urology department. In two cases, we decided surgery management and in one case, we used watchful waiting. After a 3-year follow-up, case 1 was asymptomatic without changes in the lesion. Keywords: Schwannoma; Retroperitoneal malignance; Neurogenic tumor IntroductionSchwannoma is a slow-growing neurogenic tumor of the nerve sheath origin. They are commonly seen in middle-aged with a female to male ratio of 1:1.2. Visceral schwannomas are infrequent. Computerized tomography (CT) images present areas of cystic degeneration, calcification or hemorrhage. Extension of the mass along the nerve may indicate the neural origin of the mass. It is important to exclude a malignant retroperitoneal tumor to choose the correct treatment.Here we present three cases of retroperitoneal schwannoma in our urology department. Case Reports Case 1A 54-year-old female smoker presented in our department with back pain on the right. Abdominal ultrasound and CT with contrast revealed a 4.2 × 3.2 cm mass located in the retrocaval area and medial to the right kidney (Fig. 1). The findings of the images were compatible with pheochromocytoma or paraganglioma. Biochemical workup included plasma and urine catecholamine. All studies were normal. The imagingguided biopsy was done. Microscopic findings showed a mass composed of fusiform cells with abundant collagen and spaces with macrophages. No mitoses were observed. Immunohistochemistry showed that the tumor cells were positive for S-100, BCL2, CD56, CD99 and negative for CD34 and muscle specific actin and desmin. The Ki67 activity was 1%. These findings were consistent with benign schwannoma.Because it was a benign case with small mass and the patient was asymptomatic, we decided watchful waiting with radiological periodic controls. Case 2A 56-year-old woman smoker was dispatched to the hematology department with thrombocytopenia after a routine health

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 97%

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Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Fernández

Villamil

Fernández-Pello

et al. 2016

World J Nephrol Urol

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“…Realizou ultrassom abdominal em outro serviço, que mostrou uma volumosa massa sólida com fluxo localizada nas regiões do epigástrio, hipogástrio e fossa ilíaca esquerda. Os seguintes exames laboratoriais foram realizados na emergência: hematócrito 32,8%, hemoglobina 11,3 g/100ml, leucócitos 6.900/ mm 3 Foram colhidos também os marcadores tumorais e os resultados estavam dentro do limite da normalidade: Antígeno carcinoembrionário (CEA) de 1,0 ng/ml, alfafetoproteína (AFP) de 1,8 ng/ml e CA 19-9 sérico de 6,0 U/ml. Na tomografia computadorizada (TC) de tórax não foram visualizados sinais indicativos de metástases ou outras alterações significativas.…”

Section: Relato De Casounclassified

“…Ocorre principalmente entre os 20 e 50 anos e, geralmente, está associado à neurofibromatose tipo 1 (NF1 ou doença de Von Recklinghausen) ou vários anos após tratamento por radioterapia (1) . A forma retroperitoneal é incomum, com incidência de apenas 1-10% entre os tumores retroperitoneais (3) , existindo poucos casos descritos na literatura. Geralmente manifesta-se como uma massa de crescimento rápido e progressivo e apresenta sintomas, como dor e déficits…”

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Ressecção De Tumor Maligno Da Bainha Do Nervo Periférico Retroperitoneal: Relato De Caso

Ayub¹,

Hussain²,

Beolchi³

et al. 2016

ACS

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Confrito de interesses:Não Contribuição dos autores: KMKH concepção e planejamento do projeto de pesquisa, redação e revisão crítica. GB concepção e planejamento do projeto de pesquisa, redação e revisão crítica. NECA concepção e planejamento do projeto de pesquisa, obtenção ou análise/interpretação dos dados, redação e revisão crítica. EYY concepção e planejamento do projeto de pesquisa, obtenção ou análise/interpretação dos dados, redação e revisão crítica. GNM concepção e planejamento do projeto de pesquisa, obtenção ou análise/interpretação dos dados, redação e revisão crítica. Resumo Introdução: O tumor de bainha do nervo periférico é um tumor raro, sendo a forma maligna ainda mais rara e agressiva, correspondendo entre 5-10% de todos os sarcomas com uma frequência de 0,001% na população geral. A forma retroperitoneal é incomum, com incidência de apenas 1-10% entre os tumores retroperitoneais, existindo poucos casos descritos na literatura. Relato de Caso: O objetivo deste trabalho é relatar, juntamente com a revisão da literatura atual, um caso raro de uma paciente portadora de tumor maligno da bainha do nervo periférico retroperitoneal, sem fatores de risco, submetida à ressecção cirúrgica da massa tumoral. Conclusão: Com o relato, pode-se obter uma melhor caracterização dos sinais e sintomas dessa doença para o conhecimento médico, proporcionando maior grau de suspeição para o diagnóstico. Assim, possibilita o diagnóstico precoce e o aumento da sobrevida dos pacientes.Descritores: Neurilemoma; Sarcoma; Neurofibromatose 1. Abstract Introduction:Peripheral nerve sheath tumor is a rare neoplasm with an even more malignant, rare, and aggressive form. It corresponds to 5-10% of all sarcomas with a frequency of 0.001% in the general population. The retroperitoneal form is uncommon. It has an incidence of only 1-10% of all retroperitoneal tumors, and there are a few cases reported in the literature. Case Report: The objective of this study is to report, together with a review of the current literature, a rare case of a female patient with a retroperitoneal malignant peripheral nerve sheath tumor with no-risk factors, who underwent surgical resection of the tumor mass. Conclusion: With this case report, one can achieve a better characterization of the signs and symptoms of this disease for medical knowledge. The result provides a higher degree of suspicion for diagnosis. Thus, it enables early diagnosis and increased survival of patients.Descriptors: Neurilemoma; Sarcoma; Neurofibromatosis 1. IntroduçãoO tumor maligno da bainha do nervo periférico (TMBNP), conhecido anteriormente como Schwannoma maligno, é um tumor raro e agressivo que corresponde aproximadamente entre 5-10% de todos os sarcomas, com uma frequência de 0,001% na população geral (1) . Surge da diferenciação das células da periferia do nervo ou do tecido conectivo ao seu redor (2) . Ocorre principalmente entre os 20 e 50 anos e, geralmente, está associado à neurofibromatose tipo 1 (NF1 ou doença de Von Recklinghausen) ou vários anos após tratamento...

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Clinical characteristics and prognosis of cystic degeneration in retroperitoneal schwannoma: A retrospective study of 79 patients

Xiao

Cai

et al. 2022

Cancer Medicine

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Background and Purpose: Diagnosis of retroperitoneal schwannoma (RS), especially cystic RS, is frequently missed or delayed owing to its rarity, location, nonspecific symptoms, and similarities with other tumors on various imaging modalities. This study aimed to determine associations between clinical, radiological, and histopathologic features and outcome. Materials and Methods:Seventy-nine patients with pathologically confirmed RS who underwent tumor resection between June 2010 and June 2020 were retrospectively reviewed and analyzed. Patients were stratified into three groups according to degree of tumoral cystic degeneration.Results: Cystic degeneration was significantly associated with multiple foci (p = 0.025), calcification (p = 0.012), and hemorrhage (p = 0.000), but not size (p = 0.08), high Ki-67 (p = 0.094), malignancy (p = 0.115; prevalence of cystic degeneration in the benign and malignant groups were 53.9% vs 100%), rough margin (p = 0.162), or irregular shape (p = 0.369). Malignant RS was significantly associated with multiple lymph nodes enlargement (p = 0.034). Tumor size, margins, shape, or/and multiplicity did not significantly differ between benign and malignant tumors. No recurrence occurred in patients with benign RS (mean follow-up, 45 months). All malignant tumors recurred; mean time to recurrence was 11.4 months (mean follow-up, 33 months). Conclusion:Since RS is misdiagnosed mostly as malignancy and diagnosis is often delayed, a suspicion is necessary for diagnosis when atypical features are present. In RS, cystic degeneration was not associated with tumor size, Ki-67, or malignancy; however, it was significantly associated with multiple foci, calcification, and hemorrhage. Cystic degeneration and related factors are useful for the diagnosis of RS. Malignant RS should be considered when a mass involves multiple lymph nodes. Margins, morphology, and size are not associated with

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Retroperitoneal Schwannoma: A Rare Case

Cited by 21 publications

References 4 publications

Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Ressecção De Tumor Maligno Da Bainha Do Nervo Periférico Retroperitoneal: Relato De Caso

Clinical characteristics and prognosis of cystic degeneration in retroperitoneal schwannoma: A retrospective study of 79 patients

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