Retroperitoneal Tumors With Vena Caval Extension: A Multidisciplinary Approach

Bl, Ganzel; Je, George; Ji, Harty; La, Gray

doi:10.1097/00007611-199308000-00007

Cited by 7 publications

(1 citation statement)

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“…For example, the Italian Sarcoma Collaborative Group adopted the EI regimen for primary large adult soft tissue sarcoma, and showed that the chemotherapy group obtained nearly 30 months of DFS and OS prolongation compared with the non-chemotherapy group [ 33 ]. However, SMAC meta-analysis, which included four large randomized controlled trials involving more than 1900 patients, showed no difference in OS between patients receiving postoperative monotherapy and those without chemotherapy [ 28 , 34 ]. Therefore, the specific population should be selected for adjuvant chemotherapy, and the increase of dose and combined medication should be considered.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Clinical experience with the treatment of retroperitoneal vascular leiomyosarcoma originating from large veins

et al. 2021

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Background Retroperitoneal vascular leiomyosarcoma (RVLMS) is an extremely rare disease in clinical practice, and it has poor prognosis. This article is to explore the diagnosis and treatment of RVLMS and present our experience. Methods Data of RVLMS patients were continuously collected in our hospital from August 2018 to February 2020: two males and two females with a median age of 56 (min–max = 33–61) years were included. Patients in whom paraganglioma could not be excluded were asked to take phenoxybenzamine before surgery. A multi-disciplinary team (MDT) meeting had been held and surgery was recommended. The operation procedures varied based on the tumor location, shape, and stage, and the core steps were "exposure of the retroperitoneum and tumor, identification of vital blood vessels, blocking the bloodstream, complete removal of the tumor and tumor thrombus, and release of blood flow". A Satinsky clamp was used to partially block the blood vessels. Follow-up was conveyed by revisits and phone calls. Results One patient underwent open surgery, and three patients underwent laparoscopic surgery, one of whom underwent conversion to open surgery. The procedures were finished successfully, with a median operative time of 314.5 (min–max = 224–467) mins. The median amount of intraoperative bleeding was 550 (min–max = 200–1500) ml, and three patients had transfusion during the operation. The mass was irregular in shape, with a median maximum size of 7.45 (min–max = 4.2–10.7) cm, and the pathological examination confirmed RVLMS, which has spindle-shape, high mitotic activity and atypia. One week after the operation, the median serum creatinine level was 85 (min–max = 70–99) µmol/L. The median follow-up time was 16 (min–max = 13–21) months, and 1 case reported asymptomatic recurrence. Conclusion Uncharacteristic manifestations and imaging features contribute to the problematic diagnosis of RVLMS. Comprehensive preoperative evaluation and careful surgical planning are essential. Multicenter research is needed in the future to reach a dominant consensus.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%