Retrospective analysis after endoscopic urethral injections of glutaraldehyde‐cross‐linked‐collagen or dextranomer/hyaluronic acid copolymer in bitches with urinary incontinence

Lüttmann, K.; Merle, Roswitha; Nickel, Rafael

doi:10.1111/jsap.12949

Cited by 10 publications

(10 citation statements)

References 26 publications

(34 reference statements)

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“…Furthermore, the severity of AUI (eg, the frequency and first occurrence) did not differ between affected dogs spayed with the laparoscopic or laparotomic approach. However, by using continence scoring systems addressing the associated amount of urine loss, the severity could have been assessed even more precisely. Still, according to the previously and the currently presented results, the invasiveness of the surgery (the surgical procedure and the surgical approach) did not influence the risk for AUI.…”

Section: Discussionmentioning

confidence: 99%

Do prevalence rates and severity of acquired urinary incontinence differ between dogs spayed by laparoscopy or laparotomy? Comparing apples with apples with a matched‐pair cohort study

2019

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Objective To compare the prevalence rates and severity of acquired urinary incontinence (AUI) between dogs spayed with laparoscopic and open laparotomy approaches. Study design Retrospective matched‐pair cohort study. Animals In total, 1285 privately owned dogs spayed >5 years previously were included in the study. Methods Laparoscopically spayed dogs were matched with dogs spayed by traditional laparotomy. Matching variables were breed, bodyweight, age at spaying, time of spaying in relation to the onset of puberty, time interval since spaying, and age. In 400 matched‐paired dogs, the outcome of AUI was assessed by using an owner questionnaire. A conditional logistic regression for matched pairs was performed on the data of 308 dogs. Results Among 308 dogs, 30 and 29 dogs spayed by laparotomy and laparoscopy, respectively, were affected by AUI. The identified risk factors for AUI were age and time interval since spaying. The surgical approach (laparoscopy or laparotomy) was neither revealed as a risk factor nor did it influence the severity of AUI. Conclusion The risk of AUI after spaying is not influenced by the surgical approach, (laparoscopy or laparotomy). Nearly every fifth dog spayed by laparotomy or by laparoscopy was affected by AUI. A relatively longer time interval since spaying and increased age of the dog increased the risk for AUI. Clinical significance Owners of dogs with a predisposition for AUI must be counseled about this risk when they present their dogs for spaying, regardless of surgical approach chosen.

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Section: Discussionmentioning

confidence: 99%

Do prevalence rates and severity of acquired urinary incontinence differ between dogs spayed by laparoscopy or laparotomy? Comparing apples with apples with a matched‐pair cohort study

2019

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“…Their findings identified the new copolymer as a valuable substitution. However, it provided a shorter duration of continence than bovine glutaraldehyde cross-linked collagen (Lüttmann et al, 2019).…”

Section: Urethral Bulkingmentioning

confidence: 96%

“…In that study, 22 female dogs, of which 77% were continent, were included; there was a follow-up period of only one month (Bartges and Callens, 2011). Recently, continence results after endoscopic urethral injections of dextranomer/hyaluronic acid copolymer have been reported by Lüttmann et al (2019). Their findings identified the new copolymer as a valuable substitution.…”

Section: Urethral Bulkingmentioning

confidence: 99%

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Surgical treatment of refractory incontinence in the bitch

Timmermans¹,

Goethem²,

Rooster³

2020

VDT

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Urinary incontinence is a common condition in spayed, female dogs with a reported prevalence between 3.1% and 20.1%. In the majority of dogs with acquired urinary incontinence, urethral sphincter mechanism incompetence is the underlying cause. Approximately 15% of bitches that initially respond to medical therapy ultimately become refractory. Surgical intervention is indicated when patients do not respond or become refractory to medical treatment. Based on the current literature, placement of an artificial urethral sphincter, i.e. an inflatable cuff around the proximal urethra connected to a subcutaneous injection port, provides a very reliable and longterm incontinence resolution in bitches and has a low complication rate.

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“…Mild adverse effects are reported in 15% of dogs including stranguria, hematuria, and vaginitis 12 . In a more recent study with up to 10 years follow‐up, mean continence duration after GAX implantation was 45.8 months 15 . Despite its advantages, collagen had become unavailable in many countries; therefore, there is a need for an alternative, cost effective bulking agent.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cross‐linked gelatin as a bulking agent for the management of urinary sphincter mechanism incompetence in female dogs

Chen

Shipov

Segev

2020

Veterinary Internal Medicne

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Background: Bulking agent implantation is a minimally invasive intervention for the management of urethral sphincter mechanism incompetence (USMI). Hypothesis/Objectives: To evaluate the efficacy and safety of the novel bulking agent VetFoam for the management of urinary incontinence in female dogs diagnosed with USMI. Animals: Fifteen client-owned female dogs. Methods: Prospective study. Female dogs diagnosed with USMI, refractory, or unamenable to medical treatment were included. VetFoam was injected under endoscopic guidance into the urethral submucosa. Continence score was evaluated before and after the procedure and monthly thereafter. Results: Twenty-two injection procedures were performed in 15 dogs (5 dogs underwent >1 procedure). Median age of all dogs at the time of the procedure was 111 months (range, 18-180). Median continence score significantly increased after, compared with before bulking agent injection (1.5; range, 1.0-3.5 versus 4.0; range, 1.5-5 respectively; P < .001; effect size, 2.6). Continence was achieved in 13/15 (87%) dogs after the first procedure and in 7/7 (100%) repeated procedures. Overall, 20/22 (91%) procedures resulted in high (≥4) continence scores at time of first follow-up. Mean duration of continence was 11.1 months (SD, 10.7) after the first injection. One dog (7%) developed self-limiting stranguria, pollakiuria, and tenesmus while no other apparent adverse effects were recognized in the other dogs. Conclusions and Clinical Importance: VetFoam is an apparently safe, effective novel bulking agent, which can be used as an alternative for the management of USMI.

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Retrospective analysis after endoscopic urethral injections of glutaraldehyde‐cross‐linked‐collagen or dextranomer/hyaluronic acid copolymer in bitches with urinary incontinence

Cited by 10 publications

References 26 publications

Do prevalence rates and severity of acquired urinary incontinence differ between dogs spayed by laparoscopy or laparotomy? Comparing apples with apples with a matched‐pair cohort study

Do prevalence rates and severity of acquired urinary incontinence differ between dogs spayed by laparoscopy or laparotomy? Comparing apples with apples with a matched‐pair cohort study

Surgical treatment of refractory incontinence in the bitch

Evaluation of cross‐linked gelatin as a bulking agent for the management of urinary sphincter mechanism incompetence in female dogs

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