Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

Çeltikçi, Emrah; Kaymaz, Ahmet Memduh; Akgül, Gülşah; Karaaslan, Burak; Emmez, Ömer Hakan; Börcek, Alp Özgün

doi:10.5137/1019-5149.jtn.17866-16.1

Cited by 8 publications

(5 citation statements)

References 31 publications

(56 reference statements)

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“…Although more aggressive when compared with adult forms, survival with these tumors are long with radical surgery; radiotherapy is usually delayed until repeated surgeries fail to be beneficial in order to avoid longterm consequences since these patients are in childhood age. In our experience, only five patients with subtotally removed, and worse prognosis in adults (5). On the other hand, skull base or deep meningiomas are associated with higher surgical morbidity and lower complete excision rates even though they may have less aggressive behavior, thus yielding similar recurrence and long-term outcomes (21).…”

Section: Case Illustrationmentioning

confidence: 74%

Long-term outcomes of pediatric meningioma surgery: single center experience with 23 patients

Işıkay

Hanalıoğlu²,

Narin³

et al. 2019

Turkish Neurosurgery

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AIM: To evaluate the long-term outcomes and prognostic variables in a surgical cohort of pediatric meningiomas treated in a single institution. MATERIAL and METHODS: Medical records and follow-up notes of 23 pediatric patients aged <18 years (12 male and 11 female; mean age on presentation, 13.1 ± 4.4 years) harboring 27 meningiomas operated between 1994 and 01/2019 at Hacettepe University Ihsan Dogramaci Children's Hospital were evaluated. RESULTS: One patient had neurofibromatosis (NF) type 1, and five patients had NF2. Tumors were most commonly located in the convexity (n=6) and parasagittal or falcine (n=6). Gross total resection was performed in 70.4% of cases. WHO grade I tumors accounted for 56% of all cases, whereas high-grade meningiomas accounted for 44% (33% grade II, 11% grade III). The mean follow-up duration was 10.3 ± 7.7 years. Three patients (13%) died during follow-up, and 76.2% of the patients had favorable outcome (Glasgow Outcome Scale > 3) during the last follow-up assessment. Ten patients (43.5%) had relapse. In univariate analysis, low histological grade (p=0.030) and gross total resection (p=0.024) were associated with favorable outcome. The 10-year overall survival rate was 86%. CONCLUSION: Meningiomas in the pediatric age group are surgically treatable tumors with fairly good outcomes. However, relapses are common even for low-grade tumors; therefore, long-term surveillance and aggressive treatment are needed.

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Section: Case Illustrationmentioning

confidence: 74%

Long-term outcomes of pediatric meningioma surgery: single center experience with 23 patients

Işıkay

Hanalıoğlu²,

Narin³

et al. 2019

Turkish Neurosurgery

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“…Brain AVM (bAVM) commonly presents with intracranial hemorrhage, although it may be discovered following a seizure or as an incidental finding in patients undergoing brain imaging for headache. Rarely do they cause hydrocephalus, and when they do, it is often due to obstruction of cerebrospinal fluid (CSF) pathways by a dilated venous varix [1-3].…”

Section: Introductionmentioning

confidence: 99%

Obstructive Hydrocephalus Due to Unruptured Brain Arteriovenous Malformation: Demonstrating Transcranial Color Duplex Confirmation of Cerebral Venous Hemodynamic Alterations and Color Duplex Ultrasound Confirmation of Shunt Patency

Busch

Kiat

Avolio

et al. 2019

Cureus

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Given the rarity of arteriovenous malformations of the brain (bAVMs) with concomitant obstructive hydrocephalus, few papers have commented on the resultant hydrodynamic perturbations. To date, no study has specifically investigated the effect of ventricular shunting on intracranial venous parameters as measured by transcranial color duplex ultrasound (TCCD). This study investigates whether TCCD and color duplex ultrasound are useful modalities to elucidate the physiological and hemodynamic changes in a patient with bAVM following ventricular shunting.Using TCCD, this study demonstrates that preoperatively, there is a decrease in cerebral capacitance, manifesting in a decrease in cerebral inflow and reduced venous outflow. Following shunt insertion, intracranial compliance is increased, resulting in the dilatation of previously compressed capacitance vessels and restoration of venous compliance. Color duplex ultrasound (CDU) was a useful determinant of shunt patency in the neck.We report the first TCCD assessment of hemodynamic changes of the intracranial circulation in a patient with bAVM following ventricular-peritoneal shunting. The results lend conceptual support of a pressure gradient change with high pressure that occurs in the veins as compared to the subarachnoid space.

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“…19 Finally, tumor grade strongly correlated with increased mortality which was similar to reports of analyses of other national databases and institutional series. 19,26,27…”

Section: Discussionmentioning

confidence: 99%

Trends in the Management Paradigms of Intracranial Meningioma

Aljuboori

Alhourani

Woo

et al. 2019

J Neurol Surg B Skull Base

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Objective Intracranial meningiomas are the most common primary brain tumor. Treatment paradigms have evolved over time. There are limited number of population-based studies that examine this modern evolution. Here, we describe the trends of management of intracranial meningiomas using a national database. Methods The data were obtained from the National Cancer Database for the years 2004 to 2015, the collected variables included: patients' age, gender, insurance type, income, comorbidity score, the tumor size and grade, and treatment modality (observation, surgery, radiotherapy, or combination therapy). We performed statistical analyses to detect association between unique variables and outcomes. In addition, we performed mortality analyses for various treatment modalities. Results A total of 199,096 patients with a diagnosis of intracranial meningioma were included, the majority of patients were white females, mean age of 61 years, and half of the tumors were ≤ 3 cm. Observation was the most commonly used management modality followed by surgical resection, radiotherapy, and combination therapy. For the entire time period, there was an increased use of observation as a primary management method. Predictors of mortality included increased age, larger tumor size, higher tumor grade, treatment at a community hospital, and higher comorbidity scores. Conclusion Population-based studies of intracranial meningiomas are uncommon; our study is one of the few reports that examine the changes in the modern management paradigms of meningioma in the United States over time. Additionally, we shed light on the factors that affected survival of patients with this condition.

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Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

Cited by 8 publications

References 31 publications

Long-term outcomes of pediatric meningioma surgery: single center experience with 23 patients

Long-term outcomes of pediatric meningioma surgery: single center experience with 23 patients

Obstructive Hydrocephalus Due to Unruptured Brain Arteriovenous Malformation: Demonstrating Transcranial Color Duplex Confirmation of Cerebral Venous Hemodynamic Alterations and Color Duplex Ultrasound Confirmation of Shunt Patency

Trends in the Management Paradigms of Intracranial Meningioma

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