Retrospective analysis of 515 cases of Crohn’s disease hospitalization in China: Nationwide study from 1990 to 2003

Ran, ZH; Sd, Xiao; Mh, Chen; Hu, Peng; Qian, J-M; lt,; gt, strong; Wu, Xp lt; Ouyang, Qi; Hu, Zhang; Wang, Yafang; Xia, Bing; Deng, CS; Jj, Zheng; Pang, Zhigang; Xie, Yiqiang; Lv, NH; Li, KD; Tan, Hiangkiat; Xg, Liu; Wu, King Chuen; Yq, Li

doi:10.1111/j.1440-1746.2006.04140.x

Cited by 55 publications

(25 citation statements)

References 23 publications

(18 reference statements)

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“…The young age of our patients is in consonance with the fact that CD is predominantly diagnosed in late adolescence or early adulthood [2]. The overwhelming male preponderance, though not seen in the West [2,[21][22][23][24], can either be due to India's being a low-incidence country [2], like Greece [25] or China [18], or represent a socio-referral bias where women and girls are under-represented in seeking medical attention.…”

Section: Discussionsupporting

confidence: 52%

“…The cardinal presenting features of CD in our study were not different from those described in the West or in China [18,28]. However, there was an over-representation of complicated disease (Montreal B2/B3) in comparison with that of a similar hospital-based population in the West [29] or China [18].…”

Section: Discussionmentioning

confidence: 43%

“…After the data had been entered into the Excel chart, diagnostic criteria were applied. Definite CD was considered once patients had met any of the following criteria: (1) those who fulfilled the World Health Organization (WHO) criteria for definite CD [18]; (2) those who did not meet the WHO criteria of definite CD but whose histology was compatible with CD [according to the European Crohn's and Colitis Organization (ECCO)] [19] guidelines] or whose condition had shown no response to or had relapsed after at least 4-8 weeks of anti-tubercular therapy (ATT) as per the …”

Section: Diagnosis Of CDmentioning

confidence: 99%

“…Phenotypic Classification (Montreal) and Disease Distribution [18] The Montreal classification of the whole population was as follows: age at onset, A1:A2:A3 6%:64%:30%; location of disease, L1:L2:L3:L4 32%:41%:23%:4% and disease behavior, B1:B2:B3 51%:24%:25%. Upper GI and perianal modifiers were present in 26 (15%) and 31 (17%) patients, respectively.…”

Section: Anti-tubercular Therapymentioning

confidence: 99%

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Crohn’s Disease in India: A Multicenter Study from a Country Where Tuberculosis Is Endemic

et al. 2008

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Although Crohn's disease is thought to be rare and intestinal tuberculosis common in India, Crohn's disease is being reported more often. However, there is a lack of systematic study on Crohn's disease from India. In this analysis of data from three inflammatory bowel disease clinics (two in northern India and one in eastern India), criteria for Crohn's disease were applied retrospectively: (1) World Health Organization (WHO) criteria; or (2) compatible histology (European Crohn's and Colitis Organization) or failure of response to 4-8 weeks of anti-tuberculosis therapy (Asia-Pacific guidelines); or (3) compatible macroscopic, radiologic, colonoscopic features (European Crohn's and Colitis Organization). Others were classified as probable Crohn's disease. The Montreal classification was used for disease phenotype. Age at onset and duration of symptoms (182 patients, 117 male) were 34.5 (+/-13.6; 7-73) years and 3.0 (+/-5.8; 0.1-36) years, respectively. Diarrhea (68%), abdominal pain (62%), and weight loss (57%) were common. The common intestinal complications were occult (27%) and overt (40%) gastrointestinal bleeding and obstruction (28%). There were 141 (78%) and 41 (22%) with definite and probable Crohn's disease respectively. Of 147 (81%) available histopathology specimens (endoscopic biopsy in 110; 75%), 31 (21%) had granuloma. Seventy-one out of 166 (43%) had received anti-tuberculosis therapy in the past. Results from the Montreal classification were as follows: age at onset, A1:A2:A3 6%:64%:30%; location of disease, L1:L2:L3:L4 32%:41%:23%:4%, and disease behavior, B1:B2:B3 51%:24%:25%. Twenty-six (15%) and 31 (17%) patients had upper gastrointestinal and perianal modifiers. The drugs used were: aminosalicylates (128, 70%), steroids (76, 42%), azathioprine (53, 29%), methotrexate (4, 2%), and salazopyrine (14, 8%). Sixty-six (36%) patients underwent surgical treatment. We concluded that the phenotype of Crohn's disease in India is very similar to that described in other regions of Asia and the West, except for a delay in diagnosis and a more complicated disease at diagnosis.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 43%

Section: Diagnosis Of CDmentioning

confidence: 99%

Section: Anti-tubercular Therapymentioning

confidence: 99%

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Crohn’s Disease in India: A Multicenter Study from a Country Where Tuberculosis Is Endemic

et al. 2008

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“…The duodenal mucosal histology in patients with celiac disease was graded using the Marsh-Oberhuber scheme [29]. Crohn's disease was diagnosed using a combination of endoscopic, radiological, histological features, and response to treatment [30]. Patients with malabsorption of two or more substances (abnormal urine xylose test, reduced serum B12 level, increased stool 72 h fat) when other known causes have been excluded, were diagnosed to have tropical sprue [31].…”

Section: Methodsmentioning

confidence: 99%

Suboptimal Performance of IgG Anti-tissue Transglutaminase in the Diagnosis of Celiac Disease in a Tropical Country

2009

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Serological tests using human IgA-anti-tTG have been reported to have high sensitivity and specificity in diagnosis of celiac disease. There is a paucity of data on the use of human IgG-anti-tTG in diagnosis of celiac disease. Ninety-two patients with clinical suspicion of celiac disease who underwent duodenal mucosal biopsy and celiac serology using human IgG-anti-tTG were included in this retrospective study. Diagnostic accuracy of human recombinant IgG-anti-tTG serological test for celiac disease was evaluated. Indications for celiac serological testing were diarrhea (92.3%), hypoalbuminemia (39.1%), and anemia (35.9%). Eighteen patients were diagnosed with having celiac disease and 14 (77.8%) of them were IgG-anti-tTG positive. Of the remaining 74 patients, eight (10.8%) were false-positive for IgG-anti-tTG. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG-anti-tTG in celiac disease were 77.8, 89.1, 63.6, 94.2, and 87%, respectively. Human IgG-anti-tTG alone does not perform well as a diagnostic tool for celiac disease. The utility of anti-endomysial antibodies in a similar clinical setting needs to be evaluated.

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IBD in Different Ethnic Groups: Same or Different?

Leong

Chow

Selinger

2011

Clinical Dilemmas in Inflammatory Bowel Disease

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Retrospective analysis of 515 cases of Crohn’s disease hospitalization in China: Nationwide study from 1990 to 2003

Cited by 55 publications

References 23 publications

Crohn’s Disease in India: A Multicenter Study from a Country Where Tuberculosis Is Endemic

Crohn’s Disease in India: A Multicenter Study from a Country Where Tuberculosis Is Endemic

Suboptimal Performance of IgG Anti-tissue Transglutaminase in the Diagnosis of Celiac Disease in a Tropical Country

IBD in Different Ethnic Groups: Same or Different?

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