Retrospective analysis of clinical characteristics and treatment of children and adolescents with depression

Jiang, Xiaoyu; Zheng, Hongyu; Yang, Rong; Wang, Shuo; Zhang, Hui

doi:10.3389/fpsyt.2023.1036314

“…On the clinical level, important differences exist in the manifestation of adolescent versus adult depression. While adult MDD is primarily characterized by persistent depressive mood and anhedonia adolescent depression is mostly characterized by vegetative symptoms including fatigue, insomnia, appetite and weight disturbance (Jiang et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

“…On the clinical level, important differences exist in the manifestation of adolescent versus adult depression. While adult MDD is primarily characterized by persistent depressive mood and anhedonia adolescent depression is mostly characterized by vegetative symptoms including fatigue, insomnia, appetite and weight disturbance (Jiang et al, 2023). Furthermore, somatic profiles in clinically depressed children and adolescents show occurrence of symptoms such as persistent headaches and muscle pain (Nardi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Common and separable neural alterations in adult and adolescent depression – evidence from neuroimaging meta-analyses

Bore,

Liu,

Kendrick

et al. 2024

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ImportanceDepression is a highly prevalent and debilitating disorder that often begins in adolescence. However, it remains unclear whether adults and adolescents with depression exhibit common or separate brain dysfunctions during reward processing.ObjectiveTo identify common and separable neurofunctional alterations during receipt of rewards and brain structure in adolescents and adults with depression.Data sourcesPubMed, Web of Science, and PsychInfo databases were screened for eligible depression studies published between January 2000 to January 2023.Study SelectionOriginal articles reporting whole-brain differences in adults and adolescents with depression compared to healthy controls.Data extraction and synthesisThe meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA guidelines. A coordinate-based meta-analysis was employed using Seed-based d mapping with permutation of subject images (SDM-PSI) software. Behavioral, network, and molecular-genetic characterization were conducted by established platforms.Main Outcome(s) and Measure(s)Reward outcome alterations in adults and adolescents with depression compared with healthy controls.ResultsA total of 18 adult and 12 adolescent studies comprising 734 patients and 758 healthy controls were included in the meta-analysis (adults, mean [SD] age, 34.39, [9.61]; adolescents, mean [SD] age, 13.29, [1.56] years). Both age groups exhibited common activity decreases in the right striatum (putamen, caudate) and subgenual ACC (z= -4.213, P < .0025). Adults with depression showed decreased reactivity in the right putamen (z= -4.673, P < .0025) and subgenual ACC (z= -3.832, P < .0025) while adolescents with depression showed decreased activity in the left mid cingulate (z= -3.520, P < .0025), right caudate(z= -3.276, P < .0025) but increased reactivity in the right post central gyrus (z= 3.480, P < .0025). Further meta-analytic characterization revealed that the common regions coupled with dopaminergic reward processing systems, while the adolescent-specific regions were associated with the default mode network and social functions.Conclusions and RelevanceThis meta-analysis revealed shared (caudate) and separable (putamen and mid cingulate cortex) reward-related alterations in adults and adolescents with depression. The findings suggest age-specific neurofunctional alterations and stress the importance of adolescent-specific interventions that target social functions.Key PointsQuestionDo adults and adolescents with depression exhibit common or distinct brain dysregulations during rewarding experiences?FindingsThe present neuroimaging meta-analysis including data from 1,492 participants revealed that depressed adults and adolescents exhibited decreased subgenual anterior cingulate and striatal reward reactivity while adolescents specifically showed reduced mid-cingulate and enhanced postcentral reactivity. Common regions were characterized by connectivity with dopamine-related reward processing circuits, while the adolescent-specific region showed a strong association with social processes and the default mode network.MeaningFindings suggest specific dysfunctions in adolescent depression, emphasizing the need for tailored interventions that target social domains.

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The effects of physical exercise, parent-child interaction and peer relationship on adolescent depression: An empirical analysis based on CEPS data

Li,

Ren,

Fan

2024

PLoS ONE

0

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Currently, depression is the predominant mental illness impacting adolescents, causing severe damage to their overall health. Engaging in physical exercise can not only aid in restoring adolescent physical well-being but also function as a strategy to prevent depression and lower suicide rates. Drawing upon data from the China Education Panel Survey (CEPS) conducted between 2014 and 2015, this study delves into the effects of physical exercise on alleviating depressive symptoms among adolescent students and explores the underlying mechanisms through the lens of parent-child interactions and peer relationships. The mediation effect tests indicate that physical exercise can mitigate adolescent depression by reinforcing parent-child bonds and improving peer connections. Parents and educational institutions should judiciously plan the time for adolescents to engage in both academic pursuits and physical activities, and they should encourage greater participation in sports among adolescents through various means, thereby maximizing the beneficial role of physical exercise in ameliorating adolescent depression.

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The effects of physical exercise, parent-child interaction and peer relationship on adolescent depression: an empirical nalysis based on CEPS data

Lang,

Kexin,

Bingbing

2024

Preprint

0

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Currently, depression is the predominant mental illness impacting adolescents, causing severe damage to their overall health. Engaging in physical exercise can not only aid in restoring adolescent physical well-being but also function as a strategy to prevent depression and lower suicide rates. Drawing upon data from the China Education Panel Survey (CEPS) conducted between 2014 and 2015, this study delves into the effects of physical exercise on alleviating depressive symptoms among adolescent students and explores the underlying mechanisms through the lens of parent-child interactions and peer relationships. The mediation effect tests indicate that physical exercise can mitigate adolescent depression by reinforcing parent-child bonds and improving peer connections. Parents and educational institutions should judiciously plan the time for adolescents to engage in both academic pursuits and physical activities, and they should encourage greater participation in sports among adolescents through various means, thereby maximizing the beneficial role of physical exercise in ameliorating adolescent depression.

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Retrospective analysis of clinical characteristics and treatment of children and adolescents with depression

Cited by 3 publications

References 43 publications

Common and separable neural alterations in adult and adolescent depression – evidence from neuroimaging meta-analyses

Common and separable neural alterations in adult and adolescent depression – evidence from neuroimaging meta-analyses

The effects of physical exercise, parent-child interaction and peer relationship on adolescent depression: An empirical analysis based on CEPS data

The effects of physical exercise, parent-child interaction and peer relationship on adolescent depression: an empirical nalysis based on CEPS data

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