Retrospective Analysis of Clinical Features in 101 Death Cases with COVID-19

Abstract

medRxiv preprint critical condition, and 54 patients were transferred to ICU with aggravated condition.Over fifty six percent (56.4%) of patients were laboratory confirmed by RT-PCR, and 43.6% were consistent with clinical diagnostic criteria.Among them, 64 were males and 37 were females, with average age of 65.46 years (SD 9.74). Interestingly, all deaths shwed significant difference in blood type distribution, with 44.44% of type A , 29.29% of type B , 8.08% of type AB, and 18.19% of type O.The clinical manifestations of the novel coronavirus pneumonia are non-specific,the common symptoms included fever (91,,90.10%), cough (69,68.32%) and dyspnea (75,74.26%). Neutrophils, procalcitonin(PCT),C-reactive protein(CRP),and interleukin-6(IL-6), D-dimer gradually increased with progress of the disease. Myocardial enzymes were abnormal in most patients at admission, myocardial damage indicators were significantly increased. Sixty one (60.40%) patients were given antiviral drugs, 59(58.42%),received glucocorticoids, 63.37% were given intravenous immunoglobulins, and 44.55% were treated with thymosin preparations. All patients received antibiotic treatment, 63(62.38%) were given restricted antibiotics, 23(22.78%) were administrated to antifungal drugs. Non-invasive ventilator or high-flow oxygen therapy were given in 84(83.17%) patients , and invasive mechanical ventilation was used in 76.24%

IL-6 signalling pathway inactivation with siltuximab in patients with COVID-19 respiratory failure: an observational cohort study

“…This compassionate-use program was initiated to understand the feasibility of suppressing CRP production with siltuximab and improving the outcomes in patients with COVID-19 requiring CPAP or NIV for pneumonia/ARDS treatment. Initial evidence from China where the first cases of COVID-19 emerged, indicate that excessive production inflammatory markers, such as IL-6 and CRP, correlate with severity of disease (Chen X et al 2020;Conti P et al 2020;Diao B et al 2020;Gong J et al 2020;Liu et al 2020;Yang et al 2020), and many more studies report a significant increase in IL-6 or CRP levels in patients with severe or critical COVID-19 compared with those patients with mild disease (Cai et al 2020;Chen J et al 2020;Feng C et al 2020;Huang Y et al 2020;Liu J et al 2020;Qin C et al 2020;Ruan Q et al 2020;Shi Y et al 2020;Wang Y et al 2020;Wang Z et al 2020;Wu C et al2020;Xu W et al 2020;Xu X et al 2020;Zeng Q et al 2020;Zhao Z et al 2020;Zhang B et al 2020;Zhou F et al 2020;Zhou Y et al 2020).…”

Demand for hospitalization services for COVID-19 patients in Brazil

“…We considered that 5% of the cases needed ICU admission 21,23 and half of those in ICU needed mechanical ventilation 20,21 for an average of 5 days. 24 We also simulated an alternative scenario based on Italy and assumed that 12% of the cases needed ICU admission. 4,6 These parameters were combined with assumptions of hospital occupancy and type of service to produce twelve scenarios, summarized in Table 1.…”

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