Retrospective analysis of drug-induced hypersensitivity syndrome: A study of 27 patients

Ang, Chia‐Chun; Wang, Yi‐Shi; Yoosuff, Eva-Leina M.; Tay, Yong–Kwang

doi:10.1016/j.jaad.2009.08.050

Cited by 88 publications

(96 citation statements)

References 31 publications

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“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Articles were gathered primarily from MEDLINE and then from the bibliographies of acquired reports of DRESS/DIHS (drug-induced hypersensitivity syndrome). The patients exhibited symptoms of hypersensitivity myocarditis and/or ANEM, as defined by the criteria of Bocquet, Bagot, and Roujeau.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A review of DRESS-associated myocarditis

Bourgeois¹,

Cafardi²,

Groysman³

et al. 2012

Journal of the American Academy of Dermatology

143

117

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Section: Methodsmentioning

confidence: 99%

“…Characteristics and management of reported cases of DRESS syndrome with cardiac involvement[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]53 …”

mentioning

confidence: 99%

A review of DRESS-associated myocarditis

Bourgeois¹,

Cafardi²,

Groysman³

et al. 2012

Journal of the American Academy of Dermatology

143

117

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“…A careful assessment of the described DRESS cases in the literature revealed that the appearance of new symptoms is common in DRESS [10,11,12,13,14,15,16,17]. However, these were often labeled relapses linked to infectious complications and they were seldom recognized as new drug-elicited events.…”

Section: Mdh Dress and Flare-up Reactionsmentioning

confidence: 99%

Multiple Drug Hypersensitivity

Pichler

Srinoulprasert²,

Yun³

et al. 2017

Int Arch Allergy Immunol

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Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. The second DHR includes exanthema, erythroderma, DRESS, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hepatitis, and agranulocytosis. The eliciting drugs can be identified by positive skin or in vitro tests. The drugs involved in starting the MDH are the same as for DRESS, and they are usually given in rather high doses. Fixed drug combination therapies like sulfamethoxazole/trimethoprim or piperacillin/tazobactam are frequently involved in MDH, and 30-40% of patients with severe DHR to combination therapy show T-cell reactions to both components. The drug-induced T-cell stimulation appears to be due to the p-i mechanism. Importantly, a permanent T-cell activation characterized by PD-1+/CD38+ expression on CD4+/CD25^low T cells can be found in the circulation of patients with MDH for many years. In conclusion, MDH is a drug-elicited syndrome characterized by a long-lasting hyperresponsiveness to multiple, structurally unrelated drugs with clinically diverse symptoms.

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“…Es ist eine glücklicherweise seltene, aber sehr schwere Arzneimittelreaktion. Kennzeichnend ist die ausgeprägte Beteiligung innerer Organe; die Leber ist dabei am häufigsten betroffen [2]. Die genaue Pathogenese ist noch unklar.…”

Section: Diskussionunclassified

“…Als häufi-gere Auslöser werden v. a. Antikonvulsiva, Allopurinol und unterschiedliche Antibiotika genannt. Eine interessante neue pathogenetische Hypothese der letzten Jahre ist die Reaktivierung latenter Herpesvirusinfektionen (u. a. HHV-6, CMV und EBV) im Rahmen einer solchen Arzneimittelreaktion [2,5].…”

Section: Diskussionunclassified

Makulopapulöses Exanthem mit akuter Niereninsuffizienz

Amann

et al. 2011

Hautarzt

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Acute renal failure caused by interstitial nephritis as part of a drug hypersensitivity syndrome constitutes a rare, but potentially life-threatening adverse drug reaction. We describe a patient with a mild maculo-papular rash accompanied by eosinophilia after prolonged treatment with meropenem, vancomycin, and moxifloxacin. Subsequently, a rapidly progressing renal failure developed which dominated the clinical picture. Upon cessation of all suspected drugs and therapy with high-dose steroids for 6 weeks, the renal function slowly returned to normal.

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Retrospective analysis of drug-induced hypersensitivity syndrome: A study of 27 patients

Cited by 88 publications

References 31 publications

A review of DRESS-associated myocarditis

A review of DRESS-associated myocarditis

Multiple Drug Hypersensitivity

Makulopapulöses Exanthem mit akuter Niereninsuffizienz

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