Retrospective Analysis of Hepatitis B and Hepatitis C Viruses and HIV Infections in Patients Presenting to the General Surgery Clinic and Evaluated Preoperatively

Abstract

Hepatitis B (HBV), Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) infections are important parenterally transmitted infections. The aim of this study is to determine the seroprevalence of HBsAg, anti-HBs, anti-HCV and anti-HIV in patients with preoperative preparation.Material and Method: Anti-HBs, HBsAg, anti-HCV, anti-HIV tests with chemiluminescent enzyme immune-assay method in a total of 900 patients applied to the General Surgery Clinic and were evaluated preoperatively by Abbott Architect i1000 immunoassay analyzer (Abbott Diagnostics, Illinois, USA) operated according to the manufacturer's instructions. Anti-HBs titer above 10 IU/mL, serum optical density/"cut-off" control optical density (S/ Co) ≥1 in HBsAg, anti HCV and anti-HIV tests were accepted as positive. HBV-DNA and HCV-RNA tests were performed with real-time PCR method.Results: Anti-HBs test was found to be reactive in 34.11% and nonreactive in 65.89%. HBsAg positivity was 1.0% (9/900), and anti-HCV positivity was 0.33% (3/900). Anti-HIV positivity and HBsAg-anti-HCV association were not detected. Six patients with HBsAg positivity and one patient with anti-HCV positivity were found incidentally during preoperative examinations. Conclusion:As a result of these data, it can be concluded that cost-effective serological tests for HBV and HCV infections performed in the preoperative period are extremely important in the detection of asymptomatic patients. Preoperative screening is important in terms of early diagnosis of patients before complications such as cirrhosis and HCC develop, enabling treatment, as well as enabling healthcare professionals to increase infection control measures while intervening with infected patients, to be more careful in terms of percutaneous injuries, and to reduce the risk of transmission.

Retrospective Investigation of Viral Hepatitis Seroprevalence in Patients Admitted at the Outpatient Clinics of Internal Medicine

“…In other studies conducted in our region, HBsAg and Anti-HCV seroprevalence were respectively 1.0% and 0.3% in preoperatively evaluated patients and 2.0% and 0.9% in patients hospitalized in intensive care units. [19,20] In a study where children born after the vaccination program was investigated, HBsAg reactivity was reported as 0.3%. [3] We found HBsAg seroprevalence as 0.9%, and Anti-HCV seroprevalence 0.1% in the present study.…”

Retrospective Evaluation of Serological and Molecular Tests for Determination of Anti-HCV Screening Test Cut-Off

“…Çalışmamızda da 86 177 hastanın %0.4'ü anti-HCV reaktif tespit edildi. Balıkesir' de yapılan farklı bir çalışmada da ameliyat öncesi hastaların anti-HCV reaktivite oranları çalışmamıza benzer şekilde %0.33 olarak bildirilmiştir (6). Bunlar arasında yalancı pozitifliklerin de olduğu düşünüldüğünde Balıkesir bölgesinde HCV seroprevalansının oldukça düşük olduğu tahmin edilebilir.…”