Retrospective analysis of Ki-67 antigen expression in paraffin tissue blocks of laryngeal squamous cell carcinoma

Fumic-Dunkic, Lidija; Katić, Vladimir; Janjanin, Sasa; Klapan, Ivica; Simuncic, Anamarija; Včev, Aleksandar

doi:10.1053/ajot.2003.17

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…There is a correlation between the percentage of Ki-67 -labeled cells at the time of the surgery and the TNM stage. 24 Tumors with a high percentage level of Ki-67 -labeled cells have been associated with more advanced TNM stage disease. 24 Several studies have also revealed that cell proliferation in invasive tumors measured by Ki-67 highly correlated with histologic grading in human oral squamous cell carcinoma (OSCC).…”

Section: Molecular Markers Involved In Tumor Growth Proliferation Amentioning

confidence: 99%

“…24 Tumors with a high percentage level of Ki-67 -labeled cells have been associated with more advanced TNM stage disease. 24 Several studies have also revealed that cell proliferation in invasive tumors measured by Ki-67 highly correlated with histologic grading in human oral squamous cell carcinoma (OSCC). 25 -27 In addition, a high percentage of immunolabeled cancer cells for Ki-67 has been significantly associated with neck metastases and inversely correlated with the degree of cancer cell differentiation.…”

Section: Molecular Markers Involved In Tumor Growth Proliferation Amentioning

confidence: 99%

“…29,32 These results are consistent with clinical experience, whereby rapidly proliferating tumors are more sensitive to radiation therapy than those growing slowly. 24 Bcl-2. Bcl-2 is an antiapoptotic protein, being part of the regulatory system that controls the cell cycle and the induction of apoptosis.…”

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confidence: 99%

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Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

et al. 2006

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Section: Molecular Markers Involved In Tumor Growth Proliferation Amentioning

confidence: 99%

Section: Molecular Markers Involved In Tumor Growth Proliferation Amentioning

confidence: 99%

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Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

et al. 2006

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“…Alguns estudos têm sido realizados com a finalidade de se detectar e quantificar as células tumorais em proliferação como um parâmetro importante para o prognós-tico do paciente, bem como correlacioná-la com algumas características clinicopatológicas, como estágio TNM (T: tumor, N: linfonodo, M: metástase), grau histológico de malignidade, recidiva tumoral e sobrevida do paciente (5,10,18,29) . Porém, o real valor clínico dessa possível indicação de agressividade tumoral é ainda objeto de debate.…”

Section: Discussionunclassified

Análise comparativa da proliferação celular entre carcinomas de células escamosas orais HPV-positivos e HPV-negativos

Rocha¹,

Souza²,

Pinto³

2007

J. Bras. Patol. Med. Lab.

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Introdução: O carcinoma de células escamosas oral (OSCC) representa a neoplasia maligna mais freqüente em boca, e, entre os agentes etiológicos implicados, o papilomavírus humano (HPV) tem sido extensivamente estudado nos últimos anos. Objetivo: Analisar comparativamente os índices de proliferação celular em OSCCs HPV-negativos e HPV-positivos. Material e método: A amostra consistiu em 11 casos de OSCCs HPV-positivos (10 infectados por HPV-18 e um por HPV-16 e 18) e 13 HPVnegativos, previamente analisados quanto à presença ou ausência, bem quanto à tipagem viral por proteína C reativa (PCR) (primers GP5+/GP6+) e hibridização dot blot, respectivamente. No método imunoistoquímico utilizou-se a técnica da estreptoavidina-biotina, com anticorpo para a proteína nuclear Ki-67. Resultados: O teste estatístico não-paramétrico de Mann-Whitney revelou que não houve diferença estatisticamente significativa entre os grupos HPV-positivo e HPV-negativo (p = 0,72). Discussão: Os estudos semelhantes a estes são poucos e não são concordantes em demonstrar maior atividade proliferativa tumoral nos casos HPV-positivos em relação aos HPV-negativos, seja através da análise da expressão de proteínas relacionadas ao ciclo celular, seja na análise direta da fração proliferativa tumoral. Conclusão: Não houve diferença no índice de proliferação celular entre os grupos de OSCCs HPV-positivo e HPV-negativos. abstract resumo Background: Oral Squamous Cell Carcinoma (OSCC) is the most common malignant tumor in the mouth, and the human papillomavirus (HPV) has been hardly studied as a possible etiologic agent. Objectives: The aim of this study was to compare the rates of cell proliferation in HPV-positive and HPV-negative OSCC, using the immunohistochemical antibody Ki-67. Material and method: The sample consisted of 11 cases HPV-positive OSCC (10 cases infected with HPV-18 and 1 case infected with HPV-16 and 18) and 13 cases HPV-negative OSCCs, previously analyzed regarding the presence or absence of HPV, as well as the viral type, using PCR (primers GP5+/GP6+) and dot blot hybridization, respectively. Immunohistochemical study was performed by streptoavidin-biotin technique with antibody against nuclear protein

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“…Bcl-2 expression is related to outcome following chemoradiation in HNSCC [17]. Interestingly, Ki-67 expression was associated with radiosensitivity in glottic cancer, while in laryngeal HNSCC, Ki-67 expression has been shown to correlate with advanced stage and neoplasm progression [18,19].…”

Section: Hnscc Genetic Profile Biomarkers and Targets For New Drugsmentioning

confidence: 99%

The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas

Martínez‐Useros

Garcı́a-Foncillas

2015

Oral Oncology

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Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently, it is essential to search for new biomarkers and effective therapy options to optimize HNSCC treatment. Epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of tumours. EGFR has become one of most common targets for new therapies being investigated in HNSCC. In this way, multiple therapies targeting EGFR in HNSCC have been tested but response rates are still low especially in the recurrent or metastatic setting. This has been attributed to mechanisms of resistance to EGFR-targeted therapies. Afatinib, an oral small molecule ErbB Family Blocker that irreversibly binds to ErbB1 (EGFR), ErbB2 (HER2) and ErbB4 (HER4), is being investigated in HNSCC treatment with encouraging phase II results and several ongoing phase III trials. Results of these trials will help to understand the place of afatinib in the HNSCC treatment armamentarium.

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Retrospective analysis of Ki-67 antigen expression in paraffin tissue blocks of laryngeal squamous cell carcinoma

Cited by 8 publications

References 32 publications

Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

Análise comparativa da proliferação celular entre carcinomas de células escamosas orais HPV-positivos e HPV-negativos

The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas

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