Lake Tana, Ethiopia's largest lake, has a remarkable and conservation-worthy assemblage of fish species, requiring fisheries management for sustainable exploitation. However, due to anthropogenic impacts, many of these fish species are threatened. Hence, an improved management of these resources is recommended. To allow a more sustainable exploitation of natural resources, a better understanding of the cause-effect relationships between anthropogenic impacts and environmental components is fundamental. The Drivers-Pressure-State-Impact-Responses (DPSIR) framework is a useful tool to describe these links in a meaningful way to managers and policy makers. Despite its potential, application of DPSIR is virtually lacking in developing countries. This paper assessed the potential of the DPSIR framework and used it to comprehensively describe the available knowledge and management needs in the lake catchment. Rapid population growth and the economic transformation are the main driving forces leading to various pressures such as water quality and wetlands degradation as well as declining fish community, which is detrimental to the socio-economic state and health of the local inhabitants. As feedback to the driving forces, pressures, state changes and impacts, optimal multi-level responses are developed. This study aims at providing policy makers a better understanding of the lake catchment in order to bridge the gap between science and decision-making.