Retrospective Analysis of Patients with Gynaecological Uterine Sarcomas in a Tertiary Hospital

Abstract

Uterine sarcomas are rare and heterogeneous malignancies accounting for 1% to 3% of all gynaecological tumours. There are many histological subtypes recognised, including leiomyosarcomas, endometrial stromal sarcoma, and uterine carcinosarcoma, although the latest has been recently discarded in this group. Despite its low incidence, these types of cancer currently entail multiple challenges, either in diagnostics or clinical management, with a poor prognosis associated. The present work aimed to complete a comparative analysis of the different histological subtypes based on the clinicopathological characteristics of our population, the therapeutic characteristics, and associated prognosis in 161 patients treated in our centre during the period between 1985 and 2020. Moreover, a systematic review grouped a total of 2211 patients with a diagnosis of uterine sarcoma from 19 articles published in 16 countries from 2002 to 2021 was performed, all with retrospective analyses. Our results showed that apart from uterine carcinosarcoma, leiomyosarcoma is the most frequent subtype of uterine sarcoma, with unique clinical, demographic, and survival parameters. To our knowledge, this is the first systematic review conducted in this field and, thus, it shows the difficulties of collecting a significant number of patients per year, a valid reason why multicentre or national registries are recommended to allow a more exhaustive analysis of this pathology.

Clinicopathological characteristics and prognosis of uterine sarcoma: A retrospective 10-year single-center study in China

“…As described in our study, 97.33% of patients received primary surgery, among who 93.15% had TH-BSO and 6.85% had a hysterectomy as their rst-line treatment within 1 month after diagnosis. This nding was in line with other studies reporting surgical treatment rates ranging from 87.6% to 98% [27]. In our research, the effect of surgery with ovarian function preservation on survival was not analyzed due to the small sample size (n=2).…”

“…In our study, 26 out of 75 patients (34.67%) had recurrence, which was slightly lower than the reported recurrence rate range of 50-70% by previous studies [24][25][26]. In addition, our study showed that all relapses occurred in the pelvis, although Maria Ruiz-Minaya [27] reported multiple metastases were common.…”

Clinicopathological Profile, Surgical Practices and Outcomes of the Patients with Uterine Sarcoma: A Single Institutional Study from Eastern India

“…Several studies in the literature have reported LMS as the most common histological subtype of uterine sarcoma. 15,16 In contrary,…”