Retrospective Analysis of Postinjection Ultrasound Imaging After Platelet-Rich Plasma or Autologous Blood: Observational Review of Anatomic Distribution of Injected Material

Loftus, Michael L.; Endo, Yoshimi; Adler, Ronald S.

doi:10.2214/ajr.11.8075

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…Although it is possible that the needle was advanced through the tendon and directly into the paratenon space, we hypothesize that the needle remained intratendinous while the injectate flowed out of the tendon and into the paratenon space. This hypothesis is supported by 3 observations: (1) some intratendinous latex deposition did in fact occur; (2) extratendinous flow has been reported after intratendinous Achilles tendon platelet‐rich plasma injections 29 , 30 ; and (3) 40% (6 of 15) of all our sonographically guided intratendinous injections resulted in extratendinous flow into the paratenon space.…”

Section: Discussionsupporting

confidence: 78%

Sonographically Guided Distal Biceps Tendon Injections

Sellon

Wempe

Smith

2014

J of Ultrasound Medicine

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Section: Discussionsupporting

confidence: 78%

Sonographically Guided Distal Biceps Tendon Injections

Sellon

Wempe

Smith

2014

J of Ultrasound Medicine

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“…Whereas some studies have claimed that L-PRP has the antibacterial property of regulating immunity and is the preferred treatment for pain relief in the medium- and long-term, 2,13 some researchers believe that the presence of leukocytes in PRP is a cause of inflammation, and the likelihood of repair decreases as the inflammation at the site of injection increases. 11,28,29 In the present research, the leukocyte content of the injected PRP was 1 to 1.5 times as high as that of the baseline PRP, suggesting that the presence of leukocytes does not disturb the healing process.…”

Section: Discussionsupporting

confidence: 50%

Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial

Nejati

Ghahremaninia

Naderi

et al. 2017

Orthopaedic Journal of Sports Medicine

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Background:Subacromial impingement syndrome (SAIS) is the most common disorder of the shoulder. The evidence for the effectiveness of treatment options is inconclusive and limited. Therefore, there is a need for more evidence in this regard, particularly for long-term outcomes.Hypothesis:Platelet-rich plasma (PRP) would be an effective method in treating subacromial impingement.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:This was a single-blinded randomized clinical trial with 1-, 3-, and 6-month follow-up. Sixty-two patients were randomly placed into 2 groups, receiving either PRP or exercise therapy. The outcome parameters were pain, shoulder range of motion (ROM), muscle force, functionality, and magnetic resonance imaging findings.Results:Both treatment options significantly reduced pain and increased shoulder ROM compared with baseline measurements. Both treatments also significantly improved functionality. However, the treatment choices were not significantly effective in improving muscle force. Trend analysis revealed that in the first and third months, exercise therapy was superior to PRP in pain, shoulder flexion and abduction, and functionality. However, in the sixth month, only shoulder abduction and total Western Ontario Rotator Cuff score were significantly different between the 2 groups.Conclusion:Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective.

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“…Furthermore L-PRP has been found more proinflammatory when injected in rabbits [40] and increased the levels of MMPs when assayed in tenocyte cultures compared with pure PRP [41]. However, other studies have pointed out the positive role of leucocytes in PRP as anti-infectious and immune regulatory agents [42–45].…”

Section: Prpmentioning

confidence: 99%

Regenerative Medicine in Rotator Cuff Injuries

Randelli

Ragone

et al. 2014

BioMed Research International

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Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life. Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing. Tissue-engineering strategies involve the use of cells and/or bioactive factors to promote tendon regeneration via natural processes. The ability of numerous growth factors to affect tendon healing has been extensively analyzed in vitro and in animal models, showing promising results. Platelet-rich plasma (PRP) is a whole blood fraction which contains several growth factors. Controlled clinical studies using different autologous PRP formulations have provided controversial results. However, favourable structural healing rates have been observed for surgical repair of small and medium rotator cuff tears. Cell-based approaches have also been suggested to enhance tendon healing. Bone marrow is a well known source of mesenchymal stem cells (MSCs). Recently, ex vivo human studies have isolated and cultured distinct populations of MSCs from rotator cuff tendons, long head of the biceps tendon, subacromial bursa, and glenohumeral synovia. Stem cells therapies represent a novel frontier in the management of rotator cuff disease that required further basic and clinical research.

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Retrospective Analysis of Postinjection Ultrasound Imaging After Platelet-Rich Plasma or Autologous Blood: Observational Review of Anatomic Distribution of Injected Material

Abstract: Our study showed that postinjection imaging may be of value in assessing the anatomic distribution of injectate after intratendinous therapy. Furthermore, our initial review found that in the majority of cases injected blood products tended to distribute beyond the local area of injection.

Cited by 32 publications

References 26 publications

Sonographically Guided Distal Biceps Tendon Injections

Sonographically Guided Distal Biceps Tendon Injections

Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial

Regenerative Medicine in Rotator Cuff Injuries

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