Retrospective analysis on the efficacy of corticosteroid prophylaxis prior to elective caesarean section to reduce neonatal respiratory complications at term of pregnancy: review of literature

Paganelli, Simone; Soncini, E; Gargano, Giancarlo; Capodanno, Francesco; Vezzani, Cristina; Sala, Giovanni Battista La

doi:10.1007/s00404-013-3035-1

Cited by 13 publications

(12 citation statements)

References 44 publications

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“…After reviewing the full text of 9 studies, a total of three randomised controlled trials were included in the final analysis [9,11,12]. Two retrospective studies [6,17], three reviews [10,18] [19], an animal study [20] were excluded.. The study log and study selection is presented in figure 1.…”

Section: E P T E Dmentioning

confidence: 99%

Antenatal steroid administration in medically uncomplicated pregnancy beyond 37 weeks of gestation for the prevention of neonatal morbidities prior to elective caesarean section: a systematic review and meta-analysis of randomised controlled trials

Srinivasjois

Silva

2016

The Journal of Maternal-Fetal & Neonatal Medicine

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Section: E P T E Dmentioning

confidence: 99%

Antenatal steroid administration in medically uncomplicated pregnancy beyond 37 weeks of gestation for the prevention of neonatal morbidities prior to elective caesarean section: a systematic review and meta-analysis of randomised controlled trials

Srinivasjois

Silva

2016

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Rather, the rate of NICU admissions was higher after CS deliveries in their review [11]. More recently, studies have supported the use of antenatal steroids to reduce respiratory morbidities among babies born by elective CS at late preterm and term gestation [12][13][14].…”

Section: Introductionmentioning

confidence: 93%

The impact of cesarean section on neonatal outcomes at a university-based tertiary hospital in Jordan

Khasawneh

Obeidat

Yusef

et al. 2020

BMC Pregnancy Childbirth

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Background: Over the past two decades, there has been a steady rise in the rate of Cesarean section delivery globally. As a result, short-term and long-term maternal and neonatal complications are rising. The objective of this study is to determine the rate and indications for Cesarean section at King Abdullah University Hospital (KAUH) in Jordan and to assess the resulting neonatal outcomes. Methods: A retrospective chart review was conducted for all women and neonates delivered by Cesarean section during the period January 2016 to July 2017 at KAUH tertiary academic center. Collected data include demographic characteristics, indication for delivery, and neonatal outcomes such as NICU admission, respiratory complications, sepsis, mortality, and length of hospitalization. Results: Two thousand five hundred ninety-five Cesarean section deliveries were performed over 18 months representing a rate of 50.5% of all deliveries. Sixty percent were scheduled procedures. Seventy-two percent were performed at full term gestation. The most common indication was previously scarred uterus (42.8%) followed by fetal distress (15.5%). The rate of admission to the neonatal ICU was 30% (800/2595). After multilogistic conditional regression analysis, the factors associated with increased risk of neonatal ICU admission were found to include grandmultiparity (Adjusted OR 1.46), gestational diabetes (Adjusted OR 1.92), maternal employment (Adjusted OR 1.84), prolonged rupture of membranes (Adjusted OR 5), fetal distress (Adjusted OR 1.84), prematurity (Adjusted OR 43.78), low birth weight (Adjusted OR 42), high order multiple gestation (Adjusted OR 9.58) and low 5-min APGAR score (Adjusted OR 10). Among the babies electively delivered at early term (37-38.6 weeks), 16% were admitted to the NICU for a median length of stay of 4 days (IQR 2, 8). The most common diagnoses for admitted term neonates were transient tachypnea of newborns and respiratory distress syndrome. Conclusions: CS deliveries account for more than half the number of deliveries at our institution and almost one third of the delivered babies are admitted to the NICU. Together with the resulting maternal and neonatal consequences, this carries a major burden on the newborns, health care facilities, and involved families. Local strategies and policies should be established and implemented to improve the outcome of births.

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“…Exogenous glucocorticoids (betamethasone and dexamethasone) are given for pregnancies at risk of preterm delivery, as these steroids accelerate fetal lung surfactant expression and release, thereby decreasing respiratory compromise due to atelectasis encountered by the premature newborns [32,33]. While synthetic glucocorticoids provide immediate fetal/neonatal benefit, repeated exposure not only negatively impact fetal outcomes, but emerging data suggest that glucocorticoid exposure in utero carries risks for diseases that will manifest in adulthood.…”

Section: Glucocorticoid Effects Upon Reproductive Tissuesmentioning

confidence: 99%

Neuroprotection via Reduction in Stress: Altered Menstrual Patterns as a Marker for Stress and Implications for Long-Term Neurologic Health in Women

Prokai

Berga

2016

IJMS

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Individuals under chronic psychological stress can be difficult to identify clinically. There is often no outwardly visible phenotype. Chronic stress of sufficient magnitude not only impacts reproductive function, but also concomitantly elicits a constellation of neuroendocrine changes that may accelerate aging in general and brain aging in particular. Functional hypothalamic amenorrhea, a phenotypically recognizable form of stress, is due to stress-induced suppression of endogenous gonadotropin-releasing hormone secretion. Reversal of functional hypothalamic amenorrhea includes restoration of ovulatory ovarian function and fertility and amelioration of hypercortisolism and hypothyroidism. Taken together, recovery from functional hypothalamic amenorrhea putatively offers neuroprotection and ameliorates stress-induced premature brain aging and possibly syndromic Alzheimer’s disease. Amenorrhea may be viewed as a sentinel indicator of stress. Hypothalamic hypogonadism is less clinically evident in men and the diagnosis is difficult to establish. Whether there are other sex differences in the impact of stress on brain aging remains to be better investigated, but it is likely that both low estradiol from stress-induced anovulation and low testosterone from stress-induced hypogonadism compromise brain health.

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Retrospective analysis on the efficacy of corticosteroid prophylaxis prior to elective caesarean section to reduce neonatal respiratory complications at term of pregnancy: review of literature

Abstract: Human studies suggest that corticosteroid administration may become a proper clinical indication prior to caesarean section in the reduction of neonatal respiratory problems.

Cited by 13 publications

References 44 publications

Antenatal steroid administration in medically uncomplicated pregnancy beyond 37 weeks of gestation for the prevention of neonatal morbidities prior to elective caesarean section: a systematic review and meta-analysis of randomised controlled trials

Antenatal steroid administration in medically uncomplicated pregnancy beyond 37 weeks of gestation for the prevention of neonatal morbidities prior to elective caesarean section: a systematic review and meta-analysis of randomised controlled trials

The impact of cesarean section on neonatal outcomes at a university-based tertiary hospital in Jordan

Neuroprotection via Reduction in Stress: Altered Menstrual Patterns as a Marker for Stress and Implications for Long-Term Neurologic Health in Women

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