Retrospective Audit of Various Surgical Modalities Adopted for Giant Cell Tumor in a Rural Tertiary Cancer Center

Ankalkoti, Basavaraj; Satheesan, B; Jayaprakash, Dipin; Nizamudheen, P; Sangeetha, N.

doi:10.1007/s13193-019-00926-5

Cited by 5 publications

(11 citation statements)

References 21 publications

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“…Our literature search yielded 38 observational studies [ 4 , 5 , 6 , 7 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] published between 1949 and 2016, which examined the outcome of cryosurgery in patients with giant cell tumours of the bone. Table 1 shows the detailed features of the included articles.…”

Section: Resultsmentioning

confidence: 99%

“…The advantage of extralesional excision of giant cell tumours involving the joint is that it can eradicate the disease but result in poor functional outcomes. Resection of the pelvic, sacrum, coccyx, distal ulna, proximal radius, and fibula, tubular bones of the hand and foot is indicated when reconstruction is not possible, such as in pathological fractures and large lesions with a cortical breach which is insufficient to retain cement [ 4 ]. Our study shows no significant difference in recurrence rate comparing cryosurgery with marginal excision ( p = 0.42) but significantly different from wide local excision ( p = 0.04).…”

Section: Discussionmentioning

confidence: 99%

“…Our literature search yielded 38 observational studies [4][5][6][7] published between 1949 and 2016, which examined the outcome of cryosurgery in patients with giant cell tumours of the bone. Table 1 shows the detailed features of the included articles.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The symptoms of giant cell tumours are non-specific, such as pain, reduction in the affected joint’s range of motion, and swelling. The pathological fracture is usually associated with acute onset of pain, and the incidence of pathological fracture is approximately 10–22% [ 3 , 4 , 5 , 6 , 7 ]. The symptoms of giant cell tumours of the sacrum are usually subtle.…”

Section: Introductionmentioning

confidence: 99%

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Global Prevalence and Risk of Local Recurrence Following Cryosurgery of Giant Cell Tumour of Bone: A Meta-Analysis

Sumari

Zin

Ismail

et al. 2022

Cancers

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The challenge in the surgical treatment of giant cell tumours of bone is the relatively high recurrence rate after curettage alone. The use of a local adjuvant following curettage, on the other hand, has lowered the rate of recurrence. This systematic review and meta-analysis aimed to investigate the prevalence and risk of local recurrence of giant cell tumours of the bone after cryosurgery and the subsequent complications. Web of Science, Scopus, ScienceDirect, PubMed, and Google Scholar were searched to identify articles published until 13 October 2021. A random-effects model was used to examine the pooled prevalence and risk ratio (RR) of local recurrence in patients with giant cell tumours after cryosurgery with 95% confidence intervals (CIs). This study was registered with PROSPERO (CRD42020211620). A total of 1376 articles were identified, of which 38 studies (n = 1373, 46.2% male) were included in the meta-analysis. Following cryosurgery, the pooled prevalence of local recurrence in giant cell tumours was estimated as 13.5% [95% CI: 9.3–17.8, I2 = 63%], where European subjects exhibited the highest prevalence (24.2%). Compared to other local adjuvants. The RR of local recurrence following cryosurgery was 0.85 (95% CI: 0.63–1.17, I2 = 15%), which was not statistically significant compared to other local adjuvants. We found 3.9% fracture, 4.0% infection, 2.1% nerve injury, and 1.5% skin necrosis as the common complications. Based on the sensitivity analyses, this study is robust and reliable. This meta-analysis estimated a low prevalence of local recurrence of giant cell tumours with low complications following cryosurgery. Thus, it can be one of the adjuvant options for treating giant cell tumours.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Global Prevalence and Risk of Local Recurrence Following Cryosurgery of Giant Cell Tumour of Bone: A Meta-Analysis

Sumari

Zin

Ismail

et al. 2022

Cancers

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“…This classification system divides lowgrade tumors into stage 1 and high-grade tumors into stage 2 [18] . Various treatment modalities are recommended for spinal GCTs, such as surgery, radiotherapy, embolization, cryosurgery, cementation, and chemical adjuvants like H2O2, phenol or liquid nitrogen [17,[19][20][21] . Total en bloc surgical excision is the treatment of choice in long bones and the spine.…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of dorsal spine: A rare case report

Ghongade¹,

Chikhale²,

Pundkar³

et al. 2022

Int. J. Case Rep. Orthop.

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Giant cell tumor is a relatively rare neoplasm. In GCT the axial skeleton is extremely rarely involved. Most GCT arises in the meta-epiphyseal ends of the long bones. Peak incidence is between 30 to 40 years of age. GCT is usually classified as benign, but shows aggressive behavior and occasionally undergo transformation to malignancy. The patients with GCT in the spine often complain of the lower back pains, as the tumors primarily involve the sacrum. We report a case of an adolescent female complaining of the upper back pain with a sudden weakness of the lower extremities, later diagnosed with the GCT of the D8 vertebra. The present patient was operated using posterior lateral approach of spine and proper rehabilitation was done. Subsequent follow up revealed improvement in carrying out her daily activities.

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A Re-evaluation of Amputations versus Rotationplasties in the Reconstruction of Tumors about the Knee

Tud,

Singh,

Nathan

2023

Preprint

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Background Rotationplasties are considered superior to above knee amputations (AKA) in the reconstruction of tumor-ablated limbs. We compared both procedures performed for patients with musculoskeletal tumors about the knee, to answer the following: 1. Are subjective functional outcomes among knee rotationplasty (KRP) patients superior to above knee amputees? 2. Are objective gait parameters of above knee amputees inferior to rotationplasty patients? Methods We evaluated 19 patients who had undergone AKA or KRP for distal femur or proximal tibia tumors. Four underwent AKA, while 7 had KRP. Patients were assessed using motion capture and force plate array analysis. Subjective function was assessed using the Musculoskeletal Tumor Society (MSTS) Score. Results Ten males and 9 females were followed an average 4.0 ± SD5.5 years. Mean age was 31 ± SD10 years. Above-knee amputees showed greater thigh acceleration on the affected side (22m/s2 ± SD 9 versus 13m/s2 ± SD6 for the unaffected side, p=0.02) whereas rotationplasty patients exhibited greater acceleration on the normal side (29m/s2 ± SD7 versus 15m/s2 ± SD5, p=0.0009). Amputees exerted stronger thigh forces (166N ± SD56 versus 105N ± SD47, p=0.005) on the operated side compared to the unaffected side, while KRP patients generated weaker thigh forces on the post-operative side (105N ± SD42 versus 208 ± SD62, p=0.02). MSTS scores were not statistically significant between the two groups. Conclusions Above-knee amputated limbs are stronger and more functionally normal than rotationplasty limbs. Advances in prosthetic design may eventually circumvent the need for this more complex procedure.

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Retrospective Audit of Various Surgical Modalities Adopted for Giant Cell Tumor in a Rural Tertiary Cancer Center

Cited by 5 publications

References 21 publications

Global Prevalence and Risk of Local Recurrence Following Cryosurgery of Giant Cell Tumour of Bone: A Meta-Analysis

Global Prevalence and Risk of Local Recurrence Following Cryosurgery of Giant Cell Tumour of Bone: A Meta-Analysis

Giant cell tumor of dorsal spine: A rare case report

A Re-evaluation of Amputations versus Rotationplasties in the Reconstruction of Tumors about the Knee

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