Retrospective case series on the long-term visual and intraocular pressure outcomes of phacomorphic glaucoma

Lee, Jacky; Lai, Jimmy Shiu Ming; Yick, Doris W.F.; Tse, Raymond Kwok Kay

doi:10.1038/eye.2010.108

Cited by 72 publications

(70 citation statements)

References 9 publications

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“…26 Although studies found that the fellow eyes of patients with acute angle closure have a mean ACD that was 0.63 mm shallower than in normal controls, 27 a study on phacomorphic angle closure did not find any statistically significant association between the contralateral anterior chamber depths of mature cataracts and phacomorphic angle closure cases. 28 In our patients, fellow eyes of phacomorphic angle closure were 0.46 mm shallower than fellow of mature eyes. Eyes with ACD<2.6 mm had an odd ratio of 7.9 to develop phacomorphic angle closure as compared to eyes that have mature cataracts.…”

Section: Discussionmentioning

confidence: 93%

Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

Mansouri

Ramezani

Moghimi

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 93%

Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

Mansouri

Ramezani

Moghimi

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…Best corrected visual acuity (BCVA) assessments were converted from Snellen charts to its logarithmic minimum angle of resolution equivalent (logMAR) for statistical analysis. Visual acuities of count fingers (CF) equated to 1.7 logMAR; hand movement (HM) to 2.0 logMAR; light perception (LP) to 2.3 logMAR and no light perception (NLP) to 3.0 logMAR [17]. …”

Section: Methodsmentioning

confidence: 99%

Sensitivity, specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis

et al. 2017

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BackgroundTo assess the sensitivity, specificity, positive predictive value and negative predictive value of anterior chamber tap for the diagnosis of bacterial endophthalmitis on a population with high prevalence.MethodsRetrospective, single centre, case series study. We reviewed all medical records with clinical diagnosis of bacterial endophthalmitis in our hospital from January 1st, 2000 to December 31st 2014. From each record, we documented general demographic data, best corrected visual acuity and vitreous and aqueous tap microbiological results. All cases were further divided according to the endophthalmitis aetiology to perform individual calculations of sensitivity, specificity, positive predictive value, negative predictive value, accuracy and prevalence. We used the results of the vitreous tap as the gold standard for diagnosis of bacterial endophthalmitis. We excluded those records in which the aqueous and vitreous samples were not taken simultaneously or had an incomplete microbiological report. Significance were assessed with chi squared statistics, with an alpha value of 0.05 for statistical significance.ResultsA total of 190 cases fulfilled the inclusion/exclusion criteria. Positive culture rate from vitreous samples was 64.74%. Positive culture rate from aqueous sample was 32.11%. Bacteria isolated from aqueous samples matched those isolated from vitreous samples 78.68% of the time. The overall sensitivity was 38.21%, specificity: 75.51%, positive predictive value: 79.66%, negative predictive value: 32.74% (p = 0.08). Subgroup analysis showed that anterior chamber taps in cases of post-surgical endophthalmitis had a moderate to low sensitivity (37.73%), high specificity (93%) and high positive predictive value (95%) (p < 0.04).ConclusionThe sensitivity and specificity of anterior chamber tap are low and should not be used for critical therapeutic decisions in patients with suspected bacterial endophthalmitis. In cases of post-surgical endophthalmitis, the result of an anterior chamber tap could be used for therapeutic guidance, but only in conjunction with clinical presentation and in the absence of a better method for diagnosis.

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“…In addition, from each ophthalmological examination registered, we reviewed all data concerning the following: best-corrected visual acuity (BCVA) – converted into logarithm of the minimum angle of resolution equivalents (logMAR) for statistical analysis. Visual acuities of count fingers equaled to 1.7 logMAR, hand movement to 2.0 logMAR, light perception to 2.3 logMAR, and no light perception to 3.0 logMAR 15. From ancillary tests we noted the angiographic pattern and the anatomical localization of leakage of dye, in relation to the fovea and AS, by fluorescein angiography (FA).…”

Section: Methodsmentioning

confidence: 99%

Long-term follow-up of patients with choroidal neovascularization due to angioid streaks

Martínez-Serrano

Rodríguez-Reyes²,

Guerrero-Naranjo³

et al. 2016

OPTH

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BackgroundThe following case series describes the long-term anatomical and functional outcome of a group of seven patients with choroidal neovascularization (CNV), secondary to angioid streaks (AS), who were treated with antiangiogenic drugs in a pro re nata (PRN) regimen. After the 4-year mark, visual acuity tends to return to pretreatment level. Treatment delays and lack of awareness and self-referral by the patients are believed to be the cause of the PRN regimen failure.PurposeTo assess the long-term outcomes (>4 years) of patients with CNV due to AS treated with a PRN regimen of antiangiogenic.MethodsThis was a retrospective, case series, single-center study. We reviewed the electronic medical records from patients with CNV due to AS. From each record, we noted general demographic data and relevant medical history; clinical presentation, changes in best-corrected visual acuity (BCVA) over time, optical coherent tomography parameters, treatment and retreatment details, and systemic associations. Changes in BCVA and central macular thickness were assessed with a Wilcoxon two-sample test, with an alpha value of ≤0.05 for statistical significance.ResultsThe mean follow-up time was 53.8±26.8 months. BCVA at baseline was: 1.001±0.62 logMAR; at the end of follow-up: 0.996±0.56 logMAR (P=0.9). Central macular thickness at baseline was: 360.85±173.82 μm; at the end of follow-up: 323.85±100.34 μm (P=0.6). Mean number of intravitreal angiogenic drugs: 6±4.16 injections (range 4–15). Mean time between injections was 3.8±2.7 months (range 1.9–5.8 months).ConclusionDespite initial anatomical and functional improvement, patients at the end of the follow-up had no visual improvement after a pro re nata regimen of antiangiogenic drugs. The amount of retreatments, number of recurrences, and time between intravitreal injections were similar to previous reports with shorter follow-up.

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Retrospective case series on the long-term visual and intraocular pressure outcomes of phacomorphic glaucoma

Cited by 72 publications

References 9 publications

Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

Sensitivity, specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis

Long-term follow-up of patients with choroidal neovascularization due to angioid streaks

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