Retrospective clinical and cytogenetic study on ovarian hypoplasia in alpacas

Pearson, Lisa K.; Cargen, K.; Sandoval, S.; Tibary, Ahmed

doi:10.1016/j.theriogenology.2007.05.028

Cited by 6 publications

(3 citation statements)

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“…Gonadal hypoplasia/dysgenesis has been associated with X monosomy in several species, including alpacas, buffalos, cats, dogs, horses, llamas, and sheep (28). In alpacas and llamas, a peculiar form of chromosomal abnormalities referred to as minute chromosome syndrome (MCS) has been associated with ovarian hypoplasia (4,6). The minute chromosome is characterized by the presence of an abnormally large homolog of chromosome 36 (chr36), so that the normal chr36 looks very small, thus the name minute (7) (Figure 4A).…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Histological Features of Ovarian Hypoplasia/Dysgenesis in Alpacas

Arroyo¹,

Patino²,

Ciccarelli

et al. 2022

Front. Vet. Sci.

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Alpacas have a high incidence of congenital reproductive tract abnormalities, including ovarian hypoplasia/dysgenesis. Diagnosis of this condition is often challenging. The present study describes the clinical, ultrasonographic, and histologic features of ovarian hypoplasia/dysgenesis syndrome in 5 female alpacas. Additionally, serum AMH levels were compared between female alpacas diagnosed with ovarian hypoplasia/dysgenesis and a group of reproductively sound females (n = 11). The syndrome was suspected based on the presence of an infantile uterus and lack of ovaries by ultrasonography and laparoscopy. All females had normal female karyotype (n = 74 XX), but one presented a minute chromosome. The ovaries from these cases showed 3 main histological classifications: hypoplasia (n = 2), dysgenesis (n = 2), and dysplasia (n = 1). Serum AMH levels in affected females were significantly lower (P < 0.05) than those of reproductively sound control females. In conclusion, Serum AMH level may be helpful in the rapid diagnosis of ovarian hypoplasia/dysgenesis syndrome in alpacas. Furthermore, this syndrome in alpacas presents a variety of histological features. Different mechanisms may be involved in the derangement of ovarian differentiation. Further studies are needed to elucidate the causes of the syndrome.

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Section: Discussionmentioning

confidence: 99%

“…Ovarian hypoplasia in alpacas and llamas has been associated with several types of chromosomal abnormalities (XXX, XO, XX/XY) and the presence of the minute chromosome (4-7). However, a significant proportion of animals diagnosed with ovarian hypoplasia have normal karyotype (1,4).…”

Section: Introductionmentioning

confidence: 99%