Retrospective Cohort Study Examining the Correlates of Reported Lifetime Stimulant Use in Persons Diagnosed With Infectious Syphilis in Alberta, Canada, 2018 to 2019

Raval, Milan; Gratrix, Jennifer; Plitt, Sabrina S.; Niruban, John S.; Smyczek, Petra; Dong, Kathryn; Singh, Ameeta E.

doi:10.1097/olq.0000000000001648

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Drug use is now recognized to be associated with a higher risk of acquiring sexually transmitted infections, notably syphilis, in men and women 1–3 . The epidemic of intravenous drug use, overdose related deaths and the availability of effective therapy for hepatitis C virus (HCV) have resulted in a greater numbers of organs procured from donors with risk factors for blood‐borne infections 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…In the United States, a 171% increase in syphilis incidence was noted between 2014 and 2018 2 . Along with other disproportionately affected populations such as men who have sex with men (MSM) and people living with human immunodeficiency virus (PLWH) syphilis has become increasingly prevalent in people who inject drugs (PWID) 1–4 …”

Section: Introductionmentioning

confidence: 99%

“…2 Along with other disproportionately affected populations such as men who have sex with men (MSM) and people living with human immunodeficiency virus (PLWH) syphilis has become increasingly prevalent in people who inject drugs (PWID). [1][2][3][4] Syphilis may be transmitted through both transfusion and tissue transplant. Historically, rabbit infectivity tests transferring lymph nodes or other tissues from infected to healthy rabbits became the basis to study disease transmission and evaluate new therapies.…”

mentioning

confidence: 99%

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Serologic follow‐up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study

Fernández-García

Singh

Gratrix

et al. 2023

Clinical Transplantation

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The increased procurement of organs from donors with risk factors for blood-borne diseases and the expanding syphilis epidemic have resulted in a growing number of organs transplanted from donors with reactive syphilis serology in our center. Based on guidelines, recipients typically receive therapy shortly after the transplant, but data on outcomes are limited. The primary objective of this study was to determine syphilis seroconversion rates at three months post-transplant in recipients of solid organs procured from donors with reactive syphilis serology. Organ donors and recipients were tested for syphilis antibody; positive results were confirmed with Treponema pallidum Particle Agglutination (TPPA). Eleven donors with reactive syphilis antibody donated organs to 25 syphilis negative recipients. Three recipients seroconverted at posttransplant month 3. All of them had received therapy shortly after transplant. TPPA was negative in all 3. Despite post-transplant treatment, 3 of 25 (12%) syphilis negative recipients of organs from syphilis positive donors seroconverted at 3 months. All remained TPPA negative possibly reflecting passive antibody transfer or differing test sensitivity to low level treponemal antibodies. Further studies are needed to assess optimal syphilis transmission prevention strategies and follow up recipient testing in organ transplantation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Serologic follow‐up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study

Fernández-García

Singh

Gratrix

et al. 2023

Clinical Transplantation

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Prevalence of syphilis coinfection in hepatitis C virus positive prenatal patients from Alberta during a pilot routine screening program

Thompson

Plitt

Gratrix

et al. 2023

Canadian Liver Journal

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BACKGROUND: Alberta routinely screens pregnant patients for select communicable diseases. Hepatitis C virus (HCV) was added to the prenatal screening panel as part of a provincial pilot program in February 2020. This retrospective cross-sectional study aimed to characterize the prevalence of syphilis coinfections in prenatal patients infected with HCV following implementation of the pilot program. METHODS: Routine prenatal HCV and syphilis testing data were extracted from the Public Health Laboratory Information System over a 21-month period. HCV positivity was defined as HCV enzyme immunoassay (EIA) reactive with detected HCV ribonucleic acid (RNA) following molecular confirmation and positive results were examined for syphilis coinfections. All patients reactive on a syphilis EIA and confirmatory Treponema pallidum particle agglutination (TPPA) or follow-up rapid plasma reagin (RPR) test were considered positive for syphilis. Descriptive statistics for coinfected patients were analyzed. RESULTS: Eighty-seven prenatal patients were identified to be positive for HCV. Of those, 19 (21.8%) were reactive on the syphilis EIA and 17 (19.5%) had confirmed infections with the TPPA or RPR tests. For HCV/syphilis coinfected patients, the majority resided in metropolitan regions (64.6%), were from the lowest income quintile neighbourhoods (47.1%) and had previously tested positive for HCV (82.4%) and syphilis (64.6%) at the public health laboratory. CONCLUSIONS: The prevalence of syphilis coinfections in prenatal patients infected with HCV is high in Alberta. HCV/syphilis coinfection prevalence should be further investigated in other jurisdictions and prenatal cohorts to better understand testing and treatment options for prevention of congenital transmission.

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Infectious syphilis in women and heterosexual men in major Australian cities: sentinel surveillance data, 2011–2019

Harney

Curtis

Higgs

2023

Medical Journal of Australia

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Retrospective Cohort Study Examining the Correlates of Reported Lifetime Stimulant Use in Persons Diagnosed With Infectious Syphilis in Alberta, Canada, 2018 to 2019

Cited by 3 publications

References 18 publications

Serologic follow‐up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study

Serologic follow‐up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study

Prevalence of syphilis coinfection in hepatitis C virus positive prenatal patients from Alberta during a pilot routine screening program

Infectious syphilis in women and heterosexual men in major Australian cities: sentinel surveillance data, 2011–2019

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