Retrospective comparison of pregnancy outcomes of fresh and frozen-warmed single blastocyst transfer: a 5-year single-center experience

Cirillo, Federico; Grilli, Leonora; Ronchetti, Camilla; Paladino, Ilaria; Morenghi, Emanuela; Busnelli, Andrea; Levi-Setti, Paolo Emanuele

doi:10.1007/s10815-021-02362-3

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Another study by Cirillo et al . [ 28 ] revealed that fresh-embryo-transfers produced marked neonatal and maternal complications compared to frozen-embryo-transfer. A recent Cochrane review evaluated the adverse effects of the freeze-all approach compared to the straight IVF/ICSI approach and concluded that there was moderate-certainty information revealing that one approach was inferior to the others [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

A randomised control trial on oral dydrogesterone versus micronized vaginal progesterone pessary for luteal phase support in in vitro fertilization cycles

et al. 2023

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This study aimed to evaluate the pregnancy rates, adverse reactions, and medication costs of two luteal phase support regimens: oral dydrogesterone and micronized vaginal progesterone (MVP) pessary in in vitro fertilization cycles. A randomized open-label trial with participants randomly assigned to either 400 mg MVP twice daily or 10 mg dydrogesterone three times daily. The primary endpoints were pregnancy rates, and the secondary endpoints included tolerance, miscarriage rates, and medication cost. Per-protocol principle analysis was performed. The baseline characteristics of the 162 participants were similar. Dydrogesterone had statistically similar (p>0.05) positive pregnancy test rates fifteen days post embryo transfer (35.8% vs. 32.7%), clinical pregnancy rates at the gestational age of 6 weeks (32.1% vs. 28.8%), ongoing pregnancy rates (26.4% vs. 23.1%) and miscarriage rates at 14 weeks of gestation (9.2% vs. 9.4%) and safety profile to MVP. Dydrogesterone was better tolerated as vaginal itching was significantly more prevalent in the MVP arm (p=0.008). Dydrogesterone is significantly less expensive than MVP pessary. Oral dydrogesterone and MVP pessary had similar pregnancy rates and adverse effects. Dydrogesterone appears more user-friendly and less expensive in cases of luteal-phase support in in vitro fertilization cycles.

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Section: Discussionmentioning

confidence: 99%

A randomised control trial on oral dydrogesterone versus micronized vaginal progesterone pessary for luteal phase support in in vitro fertilization cycles

et al. 2023

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“…Ґрунтуючись на клінічних розробках, результати демонструють перевагу середнього рівня перенесення, оскільки це приводить до зниження виникнення гетеротопічних ускладнень [14]. Деякі дослідники припускають, що існує аномальна патологія маткової труби, така, як дисфункція війок, спазм міосальпінкса внаслідок вивільнення простагландину або неповного розслаблення під час маніпуляції при застосуванні допоміжних репродуктивних технологій [15].…”

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“…Установлено, що збільшити ризик позаматкової вагітності може підсадка ембріона на стадії розщеплення, ніж на стадії бластоцисти [2,12]. Деякі автори вивчають технічні проблеми процедур допоміжних репродуктивних технологій [14,17,18]. Як кожен фактор впливає на ризик виникнення позаматкової вагітності після допоміжних репродуктивних технологій, невідомо та потребує подальшого дослідження.…”

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Interstitial ectopic pregnancy (Clinical case)

Kostenko,

Proshchenko,

Slobodianyk

2024

RHW

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Ectopic pregnancy is the leading cause of I trimester maternal morbidity and mortality worldwide. Ectopic pregnancy is diagnosed in 1.5–2% of the general population and in 1.4–5.4% of patients after assisted reproductive technologies. In up to 98% of cases, an ectopic pregnancy develops in the fallopian tubes. Signs and symptoms of a ruptured fallopian tube in an ectopic pregnancy can occur between the 6th and 8th weeks of gestation.Interstitial ectopic pregnancy is a type of non-tubal ectopic pregnancy, when the attachment of a fertilized egg occurs at the junction of the interstitial part of the fallopian tube with the uterine myometrium. Localization of ectopic pregnancy not in the fallopian tube is detected infrequently – in 7-10% of all ectopic pregnancies, but this type of pregnancy is associated with a greater number of complications due to late manifestation and diagnostic difficulties.The interstitial part of the fallopian tube is approximately 1–2 cm long and 0.7 mm wide. The gestational sac, implanted in the interstitial part of the fallopian tube, is surrounded by a layer of myometrium, that is, the middle layer of the uterine wall, consisting mainly of smooth muscle cells, as well as supporting interstitial and vascular tissue. The surrounding tissue of the myometrium allows pregnancy to progress up to 12 weeks, and in the presence of its changes at this time, the uterus actually ruptures, which leads to significant bleeding or even death.The article describes a clinical case of an ectopic pregnancy in a 30-year-old woman who was hospitalized at the Perinatal Center of Kyiv after a routine examination for in vitro fertilization. The patient did not have any complaints. During a transvaginal ultrasound examination a progressive interstitial ectopic pregnancy was diagnosed, and the level of β-human chorionic gonadotropin in the blood serum corresponded to 5–6 weeks of gestation. The patient was hospitalized for surgical intervention, as a result of which the ectopic interstitial pregnancy was interrupted by excision of the uterine angle without penetration into its cavity, which was accompanied by minimal blood loss.

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Steps forward in embryo transfer technique: a retrospective study comparing direct versus afterload catheters at different time frames

Cirillo,

Immediata,

Ronchetti

et al. 2023

J Assist Reprod Genet

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Retrospective comparison of pregnancy outcomes of fresh and frozen-warmed single blastocyst transfer: a 5-year single-center experience

Cited by 4 publications

References 37 publications

A randomised control trial on oral dydrogesterone versus micronized vaginal progesterone pessary for luteal phase support in in vitro fertilization cycles

A randomised control trial on oral dydrogesterone versus micronized vaginal progesterone pessary for luteal phase support in in vitro fertilization cycles

Interstitial ectopic pregnancy (Clinical case)

Steps forward in embryo transfer technique: a retrospective study comparing direct versus afterload catheters at different time frames

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