Retrospective cross-sectional observational study on the epidemiological profile of dengue cases in Pernambuco state, Brazil, between 2015 and 2017

Nascimento, Iasmyn Dayanne Santos do; Pastor, André Filipe; Lopes, Thaísa Regina Rocha; Farias, Pablo Cantalice Santos; Gonçales, Juliana Prado; Carmo, Rodrigo Feliciano do; Durães-Carvalho, Ricardo; Silva, Caroline Simões da; Júnior, José Valter Joaquim Silva

doi:10.1186/s12889-020-09047-z

Cited by 8 publications

(20 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies demonstrated that immunity from previous ZIKV infections can neutralize subsequent DENV infections by all serotypes 26 , without exacerbating the severity of secondary heterologous infections by DENV 46 . This phenomenon could have led to higher numbers of asymptomatic or mild dengue cases 47 , resulting in low reporting of cases not only in Brazil, but also in most countries in the Americas, which experienced similar patterns of presumed low dengue cases after Zika outbreaks. Although the cross-protection of ZIKV-induced immunity on DENV infections may likely wane, its modulatory effects on DENV pathogenesis could not only explain the decline of dengue in 2017-2018, but also its resurgence in the following years, all over the Americas 48 .…”

Section: Discussionmentioning

confidence: 99%

Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

Machado

Siconelli

Oidtman

et al. 2020

Preprint

View full text Add to dashboard Cite

After Zika virus (ZIKV) emerged and caused an epidemic in the Americas in 2016, both Zika and dengue incidence declined in the following years (2017-2018) to a record low in many countries. Following this period of low incidence, dengue resurged in 2019 in Brazil, causing ~2.1 million cases. The reasons for the recent fluctuations in dengue incidence and the maintenance of dengue virus (DENV) through periods of low transmission are unknown. To investigate this, we used a combination of epidemiological and climatological data to estimate dengue force of infection (FOI) and model mosquito-borne transmission suitability since the early 2000s in Brazil. Our estimates of FOI revealed that the rate of DENV transmission in 2018-2019 was exceptionally low, due to a low proportion of susceptible population rather than changes to ecological conditions. This supports the hypothesis that the synchronous decline of dengue in Brazil may be explained by protective immunity from pre-exposure to ZIKV and/or DENV in prior years. Furthermore, we sequenced 69 genomes of dengue virus serotype 1 (DENV-1) and DENV-2 circulating in Northeast and Southeast Brazil, and performed phylogeographic analyses to uncover patterns of viral spread. We found that the outbreaks in Brazil in 2019 were caused by DENV lineages that were circulating locally prior to the Zika epidemic and spread cryptically during the period of low transmission. Despite the period of low transmission, endemic DENV lineages persisted for 5-10 years in Brazil before causing major outbreaks. Our study challenges the paradigm that dengue outbreaks are caused by recently introduced new lineages, but rather they may be driven by established lineages circulating at low levels until the conditions are conducive for outbreaks.

show abstract

Section: Discussionmentioning

confidence: 99%

Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

Machado

Siconelli

Oidtman

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Low immunity is also a factor for DENV infection ( 36 ). One study associated mixed race with a greater likelihood of developing dengue than other ethnicities ( 40 ).…”

Section: Resultsmentioning

confidence: 99%

Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: a systematic review

Santos

Aquino

Fernandes

et al. 2023

Revista Panamericana De Salud Pública

View full text Add to dashboard Cite

Objectives. To characterize the distribution profile of dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean and to identify possible factors associated with the risk of dissemination and severity of these arboviruses. Methods. The protocol of this review was registered on the PROSPERO platform. Searches were carried out in the following databases: Virtual Health Library, MEDLINE/PubMed, and Embase. The search terms were: Zika virus, Zika virus infection, dengue, dengue virus, chikungunya virus, chikungunya fever, epidemiology, observational study, Latin America, and Caribbean region. Studies that addressed the distribution of these arboviruses and the risk factors associated with dengue, Zika virus disease, and chikungunya, published between January 2000 and August 2020 in English, Portuguese, and Spanish, were included. Results. Of 95 studies included, 70 identified risk factors, clinical manifestations, and outcomes for arbovirus infections and 25 described complications and/or deaths. The highest frequency of confirmed cases was for dengue. Brazil reported most cases of the three arboviruses in the period analyzed. Environmental and socioeconomic factors facilitated the proliferation and adaptation of vectors, and host-related factors were reported to aggravate dengue. Most deaths were due to chikungunya, Zika virus disease caused most neurological alterations, and dengue resulted in greater morbidity leading to more frequent hospitalization. Conclusions. The review provides a broad view of the three arboviruses and the intrinsic aspects of infections, and highlights the factors that influence the spread of these viruses in the populations studied.

show abstract

“…In general, different age groups have been described as the most related to dengue, e . g ., 15–49, 20–29, 21–30, 21–40, 30–39, 31–40, 18 years, ≥ 30 years or > 50 years [ 15 , 17 , 38 , 41 – 44 ]. These disagreements are probably influenced by the region/territory analyzed, as well as by the study design.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of arboviruses in two different scenarios: dengue circulation vs. dengue, chikungunya and Zika co-circulation

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background The severity and distribution of dengue virus (DENV) infections have been attributed to a complex interaction among viral, host and environmental factors. Herein, we investigated the influence of chikungunya (CHIKV) and Zika (ZIKV) viruses on the epidemiological profile of dengue cases, using Recife, Pernambuco state, Brazil, as a study model. In addition, we described and compared the epidemiological profile related to each arbovirus (DENV vs. CHIKV vs. ZIKV). Methods All cases of dengue, chikungunya and Zika reported to the Pernambuco Health Department in 2011–2013 (DENV circulation) and 2016–2018 (DENV, CHIKV and ZIKV co-circulation) were included in our study. The cases were classified by sex, age and race/color and their distribution was analyzed by the χ2 test. Furthermore, the data were also analyzed for co-infections. Temperature, humidity and rainfall data were analyzed using one-way ANOVA and paired t-test. Results During 2011–2013, 15,315 dengue cases were diagnosed, most of them female, brown and 20–29 age group. Between 2016 and 2018, 15,870 dengue cases were described, which presented the same profile described above. In the two triennia, the female/male dengue ratio fluctuated significantly, ranging from 1.07 to 1.52. Regarding chikungunya, 7076 cases were reported, most of them female and brown. The female/male ratio also fluctuated significantly, ranging from 1.62 to 2.1. Two main age groups were observed in chikungunya: ≤ 19 years (minority of diagnoses) and ≥ 20 years (majority of diagnoses). In the same triennium, 266 Zika cases were reported to the Pernambuco Health Department, mainly in females and in the 0–9 and 20–39 age groups. In general, 119 co-infections were identified: 117 DENV-CHIKV, 1 CHIKV-ZIKV and 1 DENV-CHIKV-ZIKV. Concerning climate data, only the humidity in 2011 was significantly different from the other years. Conclusion The epidemiological profile of dengue cases did not change after the introduction of CHIKV and ZIKV. Females were the most diagnosed with dengue, chikungunya or Zika, however we found important differences in the age profile of these arboviruses, which should be considered by public health policies, as well as investigated in future studies of virus-host interaction.

show abstract

Retrospective cross-sectional observational study on the epidemiological profile of dengue cases in Pernambuco state, Brazil, between 2015 and 2017

Cited by 8 publications

References 49 publications

Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: a systematic review

Epidemiological profile of arboviruses in two different scenarios: dengue circulation vs. dengue, chikungunya and Zika co-circulation

Contact Info

Product

Resources

About