Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better

Natoli, Silvia; Lazzari, Marzia; Carpenedo, Roberta; Palombo, Elisa; Silvi, Maria Beatrice; Mammucari, Massimo; Dauri, Mario

doi:10.1007/s12325-016-0339-0

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“…The combination of acetaminophen and oxycodone provides a synergistic and opioid-sparing effect. Additionally, this combination has a safe pharmacokinetic profile, without increasing the incidence of drug addiction and acetaminophen-associated hepatotoxicity [3] , [4] , [5] , [6] , [7] . As the abuse of prescription opioids continues to rise, measurement of acetaminophen and oxycodone in human plasma will help researchers with better drug monitoring.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

Zhao²,

Gong

et al. 2018

Journal of Pharmaceutical Analysis

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A simple and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for simultaneous determination of acetaminophen and oxycodone in human plasma. Acetaminophen-d4 and oxycodone-d3 were used as internal standards. The challenge encountered in the method development that the high plasma concentration level of acetaminophen made the MS response saturated while the desired lower limit of quantification (LLOQ) for oxycodone was hard to reach was well solved. The analytes were extracted by protein precipitation using acetonitrile. The matrix effect of the analytes was avoided by chromatographic separation using a hydrophilic C18 column coupled with gradient elution. Multiple reaction monitoring in positive ion mode was performed on tandem mass spectrometer employing electrospray ion source. The calibration curves were linear over the concentration ranges of 40.0–8000 ng/mL and 0.200–40.0 ng/mL for acetaminophen and oxycodone, respectively. This method, which could contribute to high throughput analysis and better clinical drug monitoring, was successfully applied to a pharmacokinetic study in healthy Chinese volunteers.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

Zhao²,

Gong

et al. 2018

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

show abstract

Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better

Abstract: Sponsorship for article processing charges was provided by Molteni Farmaceutici, Florence, Italy.

Cited by 1 publication

References 20 publications

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

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