Retrospective Evaluation of Anti-Toxoplasma gondii Antibody Among First Trimester Pregnant Women Admitted to Nenehatun Maternity Hospital between 2013-2017 in Erzurum

Tanrıverdi, Esra Çınar; Kadıoğlu, Berrin Göktuğ; Alay, Handan; Özkurt, Zülal

doi:10.5152/tpd.2018.5544

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…In the Americas context, the seroprevalence found in this study is lower than the 39.8% to 51% seroprevalence of T. gondii infection reported in pregnant women in Cali City, Colombia; 14 Bahia State, Brazil; 15 and 10 English-speaking Caribbean countries. 16 In addition, the seroprevalence found in pregnant women in Matehuala City is lower than the 11.1% to 21.9% seroprevalences of T. gondii infection reported in European countries including Spain, 17 Portugal, 18 Turkey 19 and Sweden. 20 It is not clear why the seroprevalence found in the current study is lower than those reported in pregnant women in other countries.…”

Section: Discussionmentioning

confidence: 74%

Toxoplasma gondiiinfection in pregnant women: a cross-sectional study in Matehuala City, Mexico

et al. 2020

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ObjectivesThis study aimed to determine the seroprevalence of Toxoplasma gondii (T. gondii) infection in pregnant women in Matehuala City, Mexico; and the associated risk factors.DesignA cross-sectional study.SettingMatehuala City, Mexico.Participants311 pregnant women.Primary and secondary outcome measuresSera of women were analysed for anti-T. gondii IgG and IgM antibodies by commercially available immunoassays. Bivariate and multivariate analyses were used to assess the association between T. gondii seroprevalence and the characteristics of the pregnant women.ResultsThirteen (4.2%) of the 311 pregnant women studied were positive for anti-T. gondii IgG antibodies. No anti-T. gondii IgM antibodies were found in anti-T. gondii IgG seropositive women. No association between seropositivity and history of blood transfusion, transplantation, caesarean sections, deliveries, miscarriages or number of pregnancies was found. Logistic regression analysis of sociodemographic, behavioural and housing variables showed that availability of potable water at street represented a risk factor for T. gondii infection (age-adjusted OR=2.18; 95% CI: 1.05 to 4.53; p=0.03), whereas being born in Mexico was a protective factor for infection (age-adjusted OR=0.01; 95% CI: 0.001 to 0.35; p=0.008).ConclusionsIn this first study on the seroepidemiology of T. gondii infection in pregnant women in Matehuala, we conclude that the seroprevalence of T. gondii infection is low and similar to those reported in pregnant women in other Mexican cities. However, the seroprevalence found is lower than those reported in pregnant women in other countries in the Americas and Europe. Two risk factors associated with T. gondii infection were identified. Results of the present study may help for the optimal planning of preventive measures against toxoplasmosis in pregnant women.

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Section: Discussionmentioning

confidence: 74%

Toxoplasma gondiiinfection in pregnant women: a cross-sectional study in Matehuala City, Mexico

et al. 2020

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“…The most common symptoms seen in the human are lymphadenopathy and a flu-like clinical condition accompanied by fever, headache, sore throat, and muscle-and joint pain. However, it can cause severe symptoms in immunocompromised individuals and pregnant women [6,7].…”

Section: Cause and Transmissionmentioning

confidence: 99%

“…However, serious regional differences are also mentioned within the same country. In Turkey, T. gondii prevalence is high due to the climatic and local characteristics, and seropositivity among pregnant women varies between 22-47% [6]. The highest seropositivity was reported in Kahramanmaraş (47.1%) in pregnant women and in Şanlıurfa (69.5%) in a mixed population [13,14].…”

Section: Prevalencementioning

confidence: 99%

“…In contrast to the possibility of infection, the likelihood of neurological damage and sequelae is highest in the first trimester. Although the risk of infection of the fetus increases with the progression of the gestational week, there is less risk of severe disease [6,16,17]. Seronegative pregnants carry the risk of infection during pregnancy [7].…”

Section: Transplacental Spreadmentioning

confidence: 99%

“…The reference test for the diagnosis of toxoplasmosis is the "Sabin-Feldman Dye" test. However, serological tests are due to their ease of administration, high sensitivity and specificity, and the difficult and time-consuming isolation of the organism [6,19]. The first emerging antibodies during an infection are T. gondii-specific IgM antibodies, which are usually positive on the 5 th day of the infection, increase to the highest level in the first month, and become negative within a few months.…”

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Pregnancy and Toxoplasmosis: should screening be a routine practice?

Tanrıverdi

Özkurt

Çayır

et al. 2019

Family Practice and Palliative Care

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Because infectious agents can reach the fetus through the placenta, pregnancy is regarded as a particular period for contagious diseases. Identification of infections during pregnancy and appropriate treatment can prevent fetal disorders. For this purpose, to avoid their harmful effects on fetus and newborn, various infectious diseases are screened during pregnancy. Toxoplasma gondii infection in pregnancy is transmitted through the transplacental pathway leading to severe neurological sequelae such as fetal abortion, stillbirth, intrauterine growth retardation, cranial calcifications, blindness, deafness, and mental retardation. This can lead to serious social and economic problems for the family and the infant, as well as society. To prevent these sequelae, infections during pregnancy need to be identified and appropriately treated. There are different opinions and practices in the world regarding the screening of T. gondii during pregnancy follow-up. This review aimed to assess the seroprevalence of T. gondii infection during gestation in Turkey and the world, its effects on the fetus, ways of protection, and suggestions about screening in the world and in Turkey in light of the literature, so that this becomes a guide for clinical practice for physicians.

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Isparta İlinde Farklı Yaş Gruplarında Toxoplasma gondii Seroprevalansı ve IgG Avidite Test Sonuçlarının Değerlendirilmesi

Şirin

Cezaroğlu

Arıdoğan

et al. 2020

SDÜ Tıp Fakültesi Dergisi

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AmaçToxoplasmosis, Toxoplasma gondii'nin neden olduğu tüm dünyada yaygın olarak görülen bir paraziter enfeksiyon hastalığıdır. Bu çalışmada bölgemizde farklı yaş gruplarında T.gondii seroprevalansının araştırılması ve IgG avidite test sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve YöntemOcak 2014-Aralık 2018 tarihleri arasında hastanemize başvuran anti-T.gondii IgM ve anti-T.gondii IgG testleri eşzamanlı istenilen hastaların serolojik sonuçları retrospektif olarak incelendi. Anti-T.gondii IgM ve IgG testleri chemiluminescent immunoassay yöntemiyle (Cobas e601, Roche Diagnostics, Almanya), IgG avidite testi enzyme-linked fluorescent assay yöntemiyle (VIDAS, bioMerieux, Fransa) çalışıldı. BulgularÇalışmaya alınan toplam 5454 hastada anti-T.gondii IgM ve IgG seropozitiflik oranları sırasıyla %3.8 ve %25.5 olarak bulunmuştur. IgM ve IgG seropozitiflik oranları, kadınlarda (n=3839) sırasıyla %4.7 ve %26.8, erkeklerde (n=1615) ise %1.6 ve %22.4 olarak belirlenmiştir. IgG seropozitifliği en düşük 0-10 yaş grubunda (%11.1), en yüksek >60 yaş grubunda (%55.4) saptanmıştır. IgG'si ve IgM'si birlikte pozitif olan 151 olguda ve IgG'si pozitif, IgM'si negatif olan 125 olguda avidite testi istenmiştir. IgG avidite testi uygulanan toplam 276 olgunun 43'ünde (%15.6) düşük avidite, 18'inde (%6.5) sınırda avidite ve 215'inde (%77.9) yüksek avidite saptanmıştır. IgG'si ve IgM'si birlikte pozitif olan olguların yaklaşık üçte ikisinde (%66.2) yüksek avidite saptanmış ve önceden geçirilmiş enfeksiyon olarak değerlendirilmiştir. SonuçBölgemizde, anti-T.gondii IgG seropozitiflik oranı %25.5 olarak belirlenmiş olup IgG seropozitiflik oranının yaşla birlikte arttığı görülmüştür. Anti-T.gondii IgM ve IgG'nin birlikte pozitif olduğu olgularda, IgG avidite testiyle akut enfeksiyon ile önceden geçirilmiş enfeksiyonun ayırımının yapılması doğru tanı ve tedavi açısından önemlidir.

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Retrospective Evaluation of Anti-Toxoplasma gondii Antibody Among First Trimester Pregnant Women Admitted to Nenehatun Maternity Hospital between 2013-2017 in Erzurum

Abstract: Our data was similar to the rest of the country. We suppose that every pregnant women should be educated about the disease and the transmission routes to raise an awareness and while the ones in the risk group should be screened instead of the whole group.

Cited by 10 publications

References 13 publications

Toxoplasma gondiiinfection in pregnant women: a cross-sectional study in Matehuala City, Mexico

Toxoplasma gondiiinfection in pregnant women: a cross-sectional study in Matehuala City, Mexico

Pregnancy and Toxoplasmosis: should screening be a routine practice?

Isparta İlinde Farklı Yaş Gruplarında Toxoplasma gondii Seroprevalansı ve IgG Avidite Test Sonuçlarının Değerlendirilmesi

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