Retrospective evaluation of borderline ovarian tumors: single center experience of 183 cases

Güngör, Tayfun; Cetinkaya, Nilufer; Yalçin, Hakan; Özdal, Bülent; Özgü, Emre; Başer, Eralp; Uygur, Dilek; Çağlar, Mete; Şirvan, Levent; Erkaya, Salım

doi:10.1007/s00404-014-3381-7

Cited by 18 publications

(15 citation statements)

References 21 publications

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“…In the present study, we found that surgical procedure (radical vs. conservative) was not an independent prognostic factor for DFS or OS. These findings were similar to those of previous studies [ 13 , 18 , 19 ]. We also demonstrated that hysterectomy had no impact on survival in BOT patients, similar to Menczer et al’s study [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study

et al. 2016

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BackgroundThe optimal surgical management and staging of borderline ovarian tumors (BOTs) are controversial. Institutions have different surgical approaches for the treatment of BOTs. Here, we performed a retrospective review of clinical characteristics, surgical management and surgical outcomes, and sought to identify variables affecting disease-free survival (DFS) and overall survival (OS) in patients with BOTs.MethodsA retrospective review of ten gynecological oncology department databases in Turkey was conducted to identify patients diagnosed with BOTs. The effects of type of surgery, age, stage, surgical staging, complete versus incomplete staging, and adjuvant chemotherapy were examined on DFS and OS.ResultsIn total, 733 patients with BOTs were included in the analysis. Most of the staged cases were in stage IA (70.4 %). In total, 345 patients underwent conservative surgeries. Recurrence rates were similar between the conservative and radical surgery groups (10.5 % vs. 8.7 %). Furthermore we did not find any difference between DFS (HR = 0.96; 95 % confidence interval, CI = 0.7–1.2; p = 0.576) or OS (HR = 0.9; 95 % CI = 0.8–1.1; p = 0.328) between patients who underwent conservative versus radical surgeries. There was also no difference in DFS (HR = 0.74; 95 % CI = 0.8–1.1; p = 0.080) or OS (HR = 0.8; 95 % CI = 0.7–1.0; p = 0.091) between complete, incomplete, and unstaged patients. Furthermore, receiving adjuvant chemotherapy (CT) for tumor stage ≥ IC was not an independent prognostic factor for DFS or OS.ConclusionsPatients undergoing conservative surgery did not show higher recurrence rates; furthermore, survival time was not shortened. Detailed surgical staging, including lymph node sampling or dissection, appendectomy, and hysterectomy, were not beneficial in the surgical management oF BOTs.

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Section: Discussionsupporting

confidence: 93%

Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study

et al. 2016

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“…Total abdominal hysterectomy and bilateral salpingo-oophorectomy (BSO) have been regarded as the standard treatment for BOT [ 22 – 24 ]. In this analysis, the most common recurrent site is the ovary (75%), consistent with findings from previous studies [ 25 , 26 ]. In addition, the univariate analysis showed that a fertility-sparing procedure was a significant risk factor for patient relapse.…”

Section: Discussionsupporting

confidence: 92%

“…For BOTs, consensus has also not been reached on the indications and roles of adjuvant chemotherapy. This treatment method has not been identified in this study or in previous studies as a significant favorable factor for the prognosis of patients with BOTs [ 15 , 26 ]. Trope et al [ 37 ] demonstrated that adjuvant therapy showed no prognostic benefit but had serious toxicity.…”

Section: Discussionmentioning

confidence: 78%

The safety of fertility and ipsilateral ovary procedures for borderline ovarian tumors

et al. 2017

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ObjectiveTo explore the optimal treatment options for women with borderline ovarian tumors (BOTs).Materials and MethodsThe medical records of consecutive patients with BOTs in two academic institutions were retrospectively collected. The pertinent data, including clinicopathological characteristics and, treatment and prognostic information were evaluated.ResultsA total of 281 cases of BOTs were included in this analysis. For the entire series, the 5- year disease-free survival (DFS) and overall survival (OS) rates were 91.8% and 98.5%, respectively. In the multivariate analysis, reservation of the ipsilateral ovary (HR: 0.104 [95% CI, 0.036–0.304], p = 0.000) and FIGO stage II–III (HR: 6.811 [95% CI, 2.700–17.181], p = 0.000) were the independent risk factors for recurrence. Ovarian surface involvement (HR: 64.996 [95% CI, 4.054–1041.941], p = 0.003) was the only independent prognostic factor for OS. Lymphadenectomy and adjunct chemotherapy had no significant impact on patients’ recurrence and survival (recurrence: p = 0.332 and 0.290, respectively, survival: p = 0.896 and 0.216, respectively).ConclusionsFertility-sparing surgery with healthy ovarian preservation seems safe and feasible for young women who prefer fertility-sparing treatment. Ovarian cystectomy to conserve the affected ovary/ovaries without ovarian surface involvement may be cautiously performed under fully informed consent for young women with bilateral BOTs who strongly prefer fertility-sparing treatment and have no evidence of infertility. However, long-term follow-up is necessary due to the relapse susceptibility of the ovary.

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“…In another study, increased serum CA125 levels were recorded in 40% of the patients diagnosed as stage 1 BOT and 83% of those with advanced-stage BOT ( 10 ). However, studies on other serum tumor markers including CA19-9, CA15-3 and CEA are not available ( 11 ). In our study, we detected higher serum CA-125 levels in eight patients (upper limit of normal=35 U/mL)…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Borderline Ovarian Tumors: Outcomes at a Single Center

Yılmaz

Şahin

Köleli

et al. 2019

ACC

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SUMMARY We wanted to discuss our experiences in the approach to borderline ovarian tumors, which constitute a group different from epithelial ovarian tumors with respect to their biological structure in line with retrospective information gathered from our cases. A total of 25 patients operated on for the indication of adnexal masses diagnosed as borderline ovarian tumors based on frozen section results were included in our study. Patient age, tumor diameter, tumor markers and surgeries performed were discussed in the light of the literature. Statistical analyses were performed using the SPSS software. The patient mean age was 43.84±11.34 years. The mass was localized in the right (n=13), left (n=11) or both (n=1) adnexal regions. The mean tumor diameter was 12.9±5.84 cm. Histopathologic examination established the diagnosis of serous borderline (n=14 patients) and mucinous borderline (n=11) ovarian tumors. Although the results of our study are consistent with current literature data, a greater number of current studies should be performed on borderline ovarian tumors, which are defined as a class of tumors different from epithelial ovarian tumors.

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Retrospective evaluation of borderline ovarian tumors: single center experience of 183 cases

Cited by 18 publications

References 21 publications

Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study

Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study

The safety of fertility and ipsilateral ovary procedures for borderline ovarian tumors

Retrospective Analysis of Borderline Ovarian Tumors: Outcomes at a Single Center

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