Retrospective evaluation of methionine intoxication associated with urinary acidifying products in dogs: 1,525 cases (2001–2012)

Hickey, Mara C.; Son, Tolina T.; Wismer, Tina

doi:10.1111/vec.12343

Cited by 3 publications

(3 citation statements)

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“…A couple of studies evaluating the effect of calcium sulphate supplementation in dogs (3.17 g S/kg of diet, Janczikowski et al, 2008) and cats (2.56 g S/kg of diet, Halfen et al, 2018) showed only a small and not significant urinary pH acidification effect, this result might have been due to a low intake of calcium sulphate, which was probably insufficient to produce significant urinary acidification. Multiple studies verified the effectiveness of L-methionine/DL-methionine as a urinary acidifier in humans, cats and dogs (Funaba et al, 2001;Halfen et al, 2018;Hickey et al, 2015;Jacobs et al, 2001;Siener et al, 2016;).…”

Section: Discussionmentioning

confidence: 92%

“…A couple of studies evaluating the effect of calcium sulphate supplementation in dogs (3.17 g S/kg of diet, Janczikowski et al., 2008) and cats (2.56 g S/kg of diet, Halfen et al., 2018) showed only a small and not significant urinary pH acidification effect, this result might have been due to a low intake of calcium sulphate, which was probably insufficient to produce significant urinary acidification. Multiple studies verified the effectiveness of l ‐methionine/ dl ‐methionine as a urinary acidifier in humans, cats and dogs (Funaba et al., 2001; Halfen et al., 2018; Hickey et al., 2015; Jacobs et al., 2001; Siener et al., 2016;). In the present study, urinary pH oscillated between 5.30 and 6.16 when the dogs were fed the Urinary S/O diet, and although the present study was not designed to determine the impact of any specific nutrient on urinary pH, it is expected that the methionine content of this diet had a major influence on its acidifying effect.…”

Section: Discussionmentioning

confidence: 94%

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Effects of two commercial diets and two supplements on urinary pH in dogs

Igreja,

Lourenço,

Vernooij

et al. 2023

Veterinary Medicine & Sci

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BackgroundUrinary pH manipulation by therapeutic foods or supplements is part of the treatment for urolithiasis. The effectiveness of these diets and supplements should be studied to determine which of these strategies is most effective.Hypothesis/ObjectivesTo assess the effect of the oral supplementation of potassium citrate, an ammonium chloride solution (Urical) and two dry therapeutic foods—Hill's® Prescription Diet® u/d® Canine (u/d diet) and Royal Canin® Urinary S/O dog (S/O diet)—on a dog's urinary pH at different time points over 8 h.AnimalsSeven healthy adult male research beagle dogs.MethodsA prospective interventional study lasting 31 days. The dogs either received a supplement (potassium citrate or rical) with a dry adult maintenance diet (control diet) or the therapeutic diet (u/d diet or S/O diet). Each treatment had a duration of 2–5 days, with 2‐ to 4‐day washout periods in between. Urinary pH measurements were performed every 2 h between 07h00 and 15h00, with the food being given at 07h00 and 15h00, right after urine collection. The pH measurements obtained in each of the four treatments were compared to control (same dogs fed the control diet exclusively).ResultsWhen compared to the control diet at the same time points, biologically relevant changes in urinary pH (defined as ≥0.5) were: increase with potassium citrate at 7h00 and 13h00; increase with u/d diet at 9h00, 13h00, and 15h00; decrease with S/O diet at 9h00 and 11h00; Urical did not have a detectable effect on urinary pH.Conclusions and Clinical ImportanceThe present study confirms that therapeutic foods S/O and u/d, and potassium citrate supplement affected acid‐base balance in healthy adult male beagle dogs, with the tested diets being more effective than the administered doses of the tested supplements at influencing urinary pH.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Effects of two commercial diets and two supplements on urinary pH in dogs

Igreja,

Lourenço,

Vernooij

et al. 2023

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…In order to formulate the right questions, design and carry out prospective studies, we do rely on having ample descriptive data about the clinical presentation, the course of progression, and outcome of animals affected by various toxins. So contributions such as those made by Hickey et al, DuHadway et al, and Katzenbach et al each provide needed data to improve our understanding of the toxicities presented and the clinical course of intoxications. It is with these types of information that we can one day evaluate efficacy of novel treatment protocols.…”

mentioning

confidence: 99%