2010
DOI: 10.1002/gps.2448
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Retrospective evaluation of revised criteria for the diagnosis of Alzheimer's disease using a cohort with post‐mortem diagnosis

Abstract: The revised-criteria, when applied to our cohort, offer good specificity and reasonable sensitivity when compared with the gold standard of PM diagnosis. The criteria were not more effective for early stage dementia.

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Cited by 31 publications
(30 citation statements)
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“…A diagnosis of probable AD was made according to the criteria of the NINCDS-ADRDA [37] and to the more recent criteria proposed by Dubois et al [38], whose specificity has recently been proved to be reliable (i.e. 93%, see [39]). Every patient disclosed a history of progressive cognitive impairment and underwent a battery of neuropsychological tests as part of their follow-up, confirming episodic memory impairment with no cueing-related improvement (Free and Cued Selective Reminding Test [40]), either isolated or associated with other cognitive changes (visuospatial abilities, praxia, language…).…”
Section: Methodsmentioning
confidence: 99%
“…A diagnosis of probable AD was made according to the criteria of the NINCDS-ADRDA [37] and to the more recent criteria proposed by Dubois et al [38], whose specificity has recently been proved to be reliable (i.e. 93%, see [39]). Every patient disclosed a history of progressive cognitive impairment and underwent a battery of neuropsychological tests as part of their follow-up, confirming episodic memory impairment with no cueing-related improvement (Free and Cued Selective Reminding Test [40]), either isolated or associated with other cognitive changes (visuospatial abilities, praxia, language…).…”
Section: Methodsmentioning
confidence: 99%
“…However, this study had relatively small sample size and used a gold standard of multidisciplinary team consensus rather than autopsy, the only true gold standard in AD diagnosis [61]. As such, we considered a wide range of sensitivities and specificities lower than in our base case (Additional file 1: Table S3).…”
Section: Resultsmentioning
confidence: 99%
“…Overall prevalence of AD in the referral population varies substantially across referral centers, with specialized centers diagnosing AD in approximately one-fourth of referred patients [26, 61]. Evaluation of MTL atrophy by MRI will diagnose at least half of patients with AD.…”
Section: Discussionmentioning
confidence: 99%
“…The new criteria [17] have been reported to capture the prodromal phase of the disease [19][20][21]. According to evidence reported above, a new lexicon has been proposed [22], in which the term ''AD'' should refer only to in vivo clinico-biological expression of the disease, without the need to confirm the disease by pathologic analysis.…”
Section: Novel Criteriamentioning
confidence: 97%
“…Myriad conducted a large, placebo-controlled phase II trial for Flurizan of 12-month duration in 210 patients with mild to moderate AD (MMSE score [15][16][17][18][19][20][21][22][23][24][25][26]. Patients were randomly assigned to receive tarenflurbil twice per day (400 or 800 mg or placebo) for 12 months.…”
Section: Selective Ab42-lowering Agents (Salas)mentioning
confidence: 99%