Retrospective evaluation of the cases with neonatal sepsis and antibiotic resistance of the causing microorganisms

Özdemir, Abdurrahman Avar; Elgörmüş, Yusuf

doi:10.5350/semb.20160406012446

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the same study, penicillin resistance was 94% and ampicillin resistance was %72 in S. aureus. The study of Özdemir et al stated that for S. aureus, these rates were 94.2% and 82%, whereas teicoplanin resistance was 3.3%; and vancomycin resistance was 0% (31). In our study, for CNS, penicillin and ampicillin resistance decreased while resistance to glycopeptides increased in 2014.…”

Section: Discussionsupporting

confidence: 46%

See 1 more Smart Citation

Evaluation of Our Neonatal Sepsis Cases in Terms of Causing Microorganism and Antibiotic Resistance

Bozkurt¹

2018

J Pediatr Inf

View full text Add to dashboard Cite

Objective: The purpose of the study is to evaluate sepsis cases in Neonatal Intensive Care Unit (NICU) in terms of the causative microorganisms and antibiotic resistance. Material and Methods: We retrospectively reviewed 115 patients who had been diagnosed with clinical sepsis and proven sepsis at the NICU between 01.01.2013 and 30.09.2014. Patients were classified as early (0-3 days), late (3-30 days), and very late (> 30 days) sepsis. Results: A total of 721 patients were admitted to our hospital during the study period. 11,1% (n= 80) were diagnosed with proven sepsis, and 7.6% (n= 55) were diagnosed with clinical sepsis. Early sepsis (ES), late sepsis (LS), and very late sepsis (VLS) were found to be 37%, 54.8% and 8.15%, respectively. Coagulase-negative Staphylococcus (CNS) was the most common etiologic factor in all sepsis groups. The mortality rate of Klebsiella spp. (Klebsiella pneumoniae 50%, Klebsiella oxytoca 40%) were found to be the highest. A decrease in sepsis-related mortality rate from 21.5% to 12.5% and a decrease in rate of K. pneumoniae (25% to 8.3%) was found in 2014 compared with 2013. In general, sensitivity of ampicillin and gentamicin was very low (0-18%, 23-50%, respectively). An increase in vancomycin and teicoplanin resistance (3-11%, 3-5.5%) among gram-positive microorganisms and an increase in amikacin resistance (59-83%) among gram negative microorganisms in 2014 compared with 2013 were observed. Conclusion: Close follow-up of the patient's clinic and culture results and use of microorganism specific narrow spectrum antibiotics and compliance with infection control practices will reduce resistance rates. Öz Giriş: Çalışmanın amacı hastanemiz Yenidoğan Yoğun Bakım Ünitesi (YYBÜ)'ndeki sepsis olgularının etken mikroorganizma ve antibiyotik direnci yönünden değerlendirilmesidir. Gereç ve Yöntemler: Çalışmamız 1 Ocak 2013 ve 30 Eylül 2014 tarihleri arasında YYBÜ'de klinik sepsis ile kanıtlanmış sepsis tanısı almış 115 hasta ile geriye dönük olarak incelendi. Hastalar erken (0-3. gün), geç (3-30. gün) ve çok geç (> 30. gün) sepsis olarak sınıflandırıldı. Bulgular: Belirtilen çalışma döneminde hastanemiz YYBÜ'de toplam 721 hasta yatmıştır. Hastaların %11.1 (n= 80)'i kanıtlanmış sepsis, %7.6 (n= 55)'sı klinik sepsis tanısı aldı. Sepsis tanısı alan olgularda erken sepsis (ES) %37, geç sepsis (GS) %54.8 ve çok geç sepsis (ÇGS) %8.15 oranında bulundu. Tüm sepsis gruplarında en sık etken olarak koagülaz-negatif stafilokok (KNS) saptandı. Mortalite oranı en yüksek etkenlerin Klebsiella türleri (Klebsiella pneumoniae %50, Klebsiella oxytoca %40) olduğu saptandı. 2014 yılında, 2013 yılına göre sepsis ilişkili mortalite oranının %21.5'ten %12.5'e düştüğü ve gram-negatif etkenlerde, özellikle mortalitesi en yüksek etken olan K. pneumoniae'da azalma (%25'ten %8.3'e) olduğu belirlendi. Genel olarak ampisilin ve gentamisin duyarlılığı çok düşük (sırasıyla %0-18; %23-50) bulundu. 2014 yılında 2013 yılına göre gram-pozitif etkenlerde vankomisin ve teikoplanin direncinde artış (sırasıyla %3-11; %3-5.5); g...

show abstract

Section: Discussionsupporting

confidence: 46%

“…In our study, GBS and Enterococcus strains were sensitive to all antibiotics. For K. pneumoniae, in the study of Ozdemir et al, the resistances of ampicillin, gentamicin and amikacin were 92%, 92%, 0%, respectively (31). In the study of Özkan et al, these rates were 80%, 20% and 20%, respectively.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Our Neonatal Sepsis Cases in Terms of Causing Microorganism and Antibiotic Resistance

Bozkurt¹

2018

J Pediatr Inf

View full text Add to dashboard Cite

show abstract

“…Our search of the databases yielded 3878 citations: 1618 from Medline, 1688 from Web of Science, 210 from Cochrane Library and 362 from IMEMR (figure 1). We also identified seven articles from other sources 23–29. Of these, 1199 were duplicate articles that were removed.…”

Section: Resultsmentioning

confidence: 99%

Neonatal early onset sepsis in Middle Eastern countries: a systematic review

Khalil

Blunt

et al. 2020

Arch Dis Child

View full text Add to dashboard Cite

BackgroundEarly onset neonatal sepsis (EOS) accounts for a significant portion of neonatal mortality, which accounts for 46% of global under five child mortality.ObjectiveThis systematic review studies the bacterial aetiology of EOS in the Middle East, susceptibility patterns to recommended empirical antibiotic therapy and whether this differs between high-income and middle-income countries in the region.MethodsArticles were collected from Medline, Web of Science, the Cochrane Library and Index Medicus for the Eastern Mediterranean Region. The articles included in our systematic review met the following criteria: published after January 2000, data relevant to the Middle East, data specific for early onset sepsis, no language restriction. Data on aetiology and susceptibility were extracted from prospective and retrospective studies. Risk of bias was assessed using the Newcastle-Ottawa Scale. This study focused on EOS but does include data regarding neonatal late-onset sepsis antibiotic susceptibility. The data regarding coagulase-negative Staphylococcus species were excluded from final analysis, as possible contaminants. The protocol for this systematic review was registered on PROSPERO: CRD42017060662.Results33 articles from 10 countries were included in the analysis. There were 2215 cases of culture-positive EOS, excluding coagulase-negative Staphylococcus. In middle-income countries, Klebsiella species (26%), Staphylococcus aureus (17%) and Escherichia coli (16%) were the most common pathogens, in contrast to group B Streptococcus (26%), E. coli (24%) and Klebsiella (9%) in high-income countries. Overall susceptibility to ampicillin/gentamicin and third-generation cephalosporin were 40% and 37%, respectively, in middle-income countries versus 93% and 91%, respectively, in high-income countries.ConclusionsEOS in middle-income countries was more likely to be due to Gram-negative pathogens and less likely to be susceptible to empirical antibiotic therapy. This has important public health implications regarding neonatal mortality in the Middle East region.

show abstract

“…In the study of Özdemir et al, S. aureus was the most common cause of late sepsis, followed by K. pneumoniae and S. epidermidis, respectively. [36] CONS was the most frequent factor in the study of Bülbül et al, [37] in which they evaluated the nosocomial infections in the neonatal intensive care unit, whereas MSSA and K. pneumonia were found in the second place.…”

Section: Pathophysiology and Causative Microorganismsmentioning

confidence: 99%

Neonatal Sepsis

Odabaşı¹

2020

Sisli Etfal

View full text Add to dashboard Cite

N eonatal sepsis defines the systemic condition that arises from the bacterial, viral or fungal origin, associated with hemodynamic changes and clinical findings and causing severe morbidity and mortality. Its incidence varies depending on the definition of the case and the population studied and is between 1 and 5 in 1000 live births. The clinical manifestations range from subclinical infection to severe focal or systemic disease. While the infectious agent may arise from intrauterine or maternal flora, it may also be of the hospital or community origin. It is classified as early-onset, late-onset and very late-onset neonatal sepsis according to the time of onset of the findings. While earlyonset neonatal sepsis describes cases where clinical manifestations occur in the first three days of life (<72 hours), some researchers consider this limit as the first seven days of life. In connection with this, late-onset neonatal sepsis describes cases diagnosed on 4 th-30 th days of life or cases diagnosed after the first seven days. [1, 2] Very late-onset neonatal sepsis, on the other hand, describes sepsis cases diagnosed in infants who are hospitalized in the neonatal intensive care unit from the first 30 days of life until discharge. Epidemiological studies related to neonatal sepsis since the early 1980s have shown a decrease in early-onset neonatal sepsis cases, especially with Group B Streptococcus (GBS), with the improvement of obstetric care and the use of intrapartum antibiotic prophylaxis; while they show an increase in late-onset neonatal sepsis associated with increased survival rates and long hospitalization times of premature babies. [3, 4] Terminology Suspected sepsis: Regardless of whether there is a clinical symptom or not, the presence of sepsis risk factors in the Neonatal sepsis is associated with severe morbidity and mortality in the neonatal period. Clinical manifestations range from subclinical infection to severe local or systemic infection. Neonatal sepsis is divided into three groups as early-onset neonatal sepsis, late-onset neonatal sepsis and very late-onset neonatal sepsis according to the time of the onset. It was observed that the incidence of early-onset neonatal sepsis decreased with intrapartum antibiotic treatment. However, the incidence of late-onset neonatal sepsis has increased with the increase in the survival rate of preterm and very low weight babies. The source of the causative pathogen may be acquisition from the intrauterine origin but may also acquisition from maternal flora, hospital or community. Prematurity, low birth weight, chorioamnionitis, premature prolonged rupture of membranes, resuscitation, low APGAR score, inability to breastfeed, prolonged hospital stay and invasive procedures are among the risk factors. This article reviews current information on the definition, classification, epidemiology, risk factors, pathogenesis, clinical symptoms, diagnostic methods and treatment of neonatal sepsis.

show abstract

Retrospective evaluation of the cases with neonatal sepsis and antibiotic resistance of the causing microorganisms

Cited by 8 publications

References 0 publications

Evaluation of Our Neonatal Sepsis Cases in Terms of Causing Microorganism and Antibiotic Resistance

Evaluation of Our Neonatal Sepsis Cases in Terms of Causing Microorganism and Antibiotic Resistance

Neonatal early onset sepsis in Middle Eastern countries: a systematic review

Neonatal Sepsis

Contact Info

Product

Resources

About