Retrospective immunogenicity analysis of seasonal flu H3N2 vaccines recommended in the past ten years using immunized animal sera

Zhang, Mingjie; An, Yimeng; Wu, Xi; Cai, Meina; Zhang, Xinyu; Yang, Chaoying; Tong, Jincheng; Cui, Zhimin; Li, Xueli; Huang, Weijin; Zhao, Chenyan; Wang, Youchun

doi:10.1016/j.ebiom.2022.104350

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…The SARS-CoV-2 pandemic has shown the public the limitations of traditional vaccines being unable to effectively respond to viral mutation escape, which is also the reason why preventive broad-spectrum vaccines have not been introduced for viruses such as HIV-1 and influenza. Influenza can still be maintained by vaccination once a year, due to the predictability of antigenicity drift of its epidemic strain [ 9 ]. The special and increasing genetic diversity of HIV-1 virus makes it particularly challenging to develop a usable HIV-1 vaccine [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Mechanism of bnAb Production and Its Application in Mutable Virus Broad-Spectrum Vaccines: Inspiration from HIV-1 Broad Neutralization Research

Zhang,

Zhou

2023

Vaccines

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Elite controllers among HIV-1-infected individuals have demonstrated a stronger ability to control the viral load in their bodies. Scientists have isolated antibodies with strong neutralizing ability from these individuals, which can neutralize HIV-1 variations; these are known as broadly neutralizing antibodies. The nucleic acid of some viruses will constantly mutate during replication (such as SARS-CoV-2), which will reduce the protective ability of the corresponding vaccines. The immune escape caused by this mutation is the most severe challenge faced by humans in the battle against the virus. Therefore, developing broad-spectrum vaccines that can induce broadly neutralizing antibodies against various viruses and their mutated strains is the best way to combat virus mutations. Exploring the mechanism by which the human immune system produces broadly neutralizing antibodies and its induction strategies is crucial in the design process of broad-spectrum vaccines.

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Section: Introductionmentioning

confidence: 99%