Retrospective investigation of prognostic indicators for adult horses with infection of a synovial structure

Walmsley, EA; Anderson, GA; Muurlink, MA; Whitton, R. C.

doi:10.1111/j.1751-0813.2011.00720.x

Cited by 41 publications

(73 citation statements)

References 35 publications

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“…These injuries cause contamination of the affected synovial structure and can subsequently lead to septic synovitis. Septic synovitis is a serious and potentially lethal condition in horses that requires immediate diagnosis and subsequent treatment [4–6]. Arthroscopic lavage is the recommended treatment of choice [2, 7–9].…”

Section: Introductionmentioning

confidence: 99%

“…However, more invasive approaches have been described in severely affected cases [10–12]. With adequate treatment, survival rates in adult horses range from 84% [6] to 90% [2] with 54% [6] to 81% [2] of horses returning to previous levels of performance [2, 4–6], except horses where solar foot penetration caused septic synovitis. In one larger scale study by Findley et al [3] survival to discharge was only 56 and 36% returned to their previous athletic function.…”

Section: Introductionmentioning

confidence: 99%

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Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

2017

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BackgroundInjuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious conditions in horses including wounds and septic arthritis. Plasma SAA levels were found to decrease rapidly once the infectious stimulus was eliminated. The purpose of the current study was to investigate the usefulness of serial measurements of plasma SAA as a monitoring tool for the response to treatment of horses presented with injuries penetrating synovial structures. In the current study plasma SAA concentrations were measured every 48 hours (h) during the course of treatment.ResultsA total of 19 horses with a wound penetrating a synovial structure were included in the current study. Horses in Group 1 (n = 12) (injuries older than 24 h) only needed one surgical intervention. Patients in this group had significantly lower median plasma SAA levels (P = 0.001) between 48 h (median 776 mg/L) and 96 h (median 202 mg/L) after surgery. A significant decrease (P = 0.004) in plasma SAA levels was also observed between 96 h after surgery (median 270 mg/L) and 6 days (d) after surgery (median 3 mg/L). Four horses (Group 2) required more than one surgical intervention. In contrast to Group 1 patients in Group 2 had either very high initial plasma concentrations (3378 mg/L), an increase or persistently high concentrations of plasma SAA after the first surgery (median 2525 mg/L). A small group of patients (n = 3) (Group 3) were admitted less than 24 h after sustaining a wound. In this group low SAA values at admission (median 23 mg/L) and peak concentrations at 48 h after surgery (median 1016 mg/L) were observed followed by a decrease in plasma SAA concentration over time.ConclusionsA decrease in plasma SAA concentrations between two consecutive time points could be associated with positive response to treatment in the current study. Therefore, serial measurements of plasma SAA could potentially be used as an additional inexpensive, quick and easy tool for monitoring the treatment response in otherwise healthy horses presented with injuries penetrating synovial structures. However further studies will be necessary to ascertain its clinical utility.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

2017

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“…82 Separate research has shown only evidence of bone or tendon involvement to negatively affect survival and athletic function. 83 Both these studies reported a rate of return to athletic function of approximately 50% after synovial sepsis. 82,83 Synovial total protein concentrations greater than 55 to 60 g/L preoperatively, and moderate to severe synovial inflammation at surgery, have been negatively associated with odds of survival to hospital discharge.…”

Section: Prognosismentioning

confidence: 96%

“…83 Both these studies reported a rate of return to athletic function of approximately 50% after synovial sepsis. 82,83 Synovial total protein concentrations greater than 55 to 60 g/L preoperatively, and moderate to severe synovial inflammation at surgery, have been negatively associated with odds of survival to hospital discharge. 84 Synovial fluid analysis at 4 to 6 days after initiation of treatment has useful prognostic value.…”

Section: Prognosismentioning

confidence: 96%

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Musculoskeletal Pathology

Peat

Kawcak

2015

Veterinary Clinics of North America: Equine Practice

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The current understanding of pathology as it relates to common diseases of the equine musculoskeletal system is reviewed. Conditions are organized under the fundamental categories of developmental, exercise-induced, infectious, and miscellaneous pathology. The overview of developmental pathology incorporates the new classification system of juvenile osteochondral conditions. Discussion of exercise-induced pathology emphasizes increased understanding of the contribution of cumulative microdamage caused by repetitive cyclic loading. Miscellaneous musculoskeletal pathology focuses on laminitis, which current knowledge indicates should be regarded as a clinical syndrome with a variety of possible distinct mechanisms of structural failure that are outlined in this overview.

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Diagnosis and Management of Wounds Involving Synovial Structures

Seabaugh¹,

Baxter²

2016

Equine Wound Management

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Retrospective investigation of prognostic indicators for adult horses with infection of a synovial structure

Abstract: Of the variables available at presentation, only evidence of bone or tendon involvement negatively affected survival and athletic function. During treatment of synovial sepsis, analysis of synovial fluid at 4-6 days and bacterial culture results have prognostic value.

Cited by 41 publications

References 35 publications

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

Musculoskeletal Pathology

Diagnosis and Management of Wounds Involving Synovial Structures

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