Retrospective investigation of the relationship between clinical and laboratory parameters and allergy tests in children with allergic rhinitis

ALTAS, Ugur; TUNCE, Eray; ALTAŞ, Zeynep Meva; ÇİÇEK, Fatih; ÖZKARS, Mehmet Yaşar

doi:10.47482/acmr.1309737

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…The patient and control groups, according to the age of individuals, are provided in Table 1. The mean diagnosis age was 8 months (1-40), and the follow up time 8 months (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The mean SCORAD score was 27.2±11.1 in < 4 years and 26.6±11.9 in ≥ 4 years age group.…”

Section: Resultsmentioning

confidence: 99%

“…11- 13 Studies conducted in pediatric patients with AD have also drawn attention to the relationship between serum total IgE, eosinophil, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and eosinophil/ lymphocyte ratio (ELR) levels and AD. [14][15][16] It has been demonstrated that neutrophilic inflammation is linked to eosinophilic inflammation in patients with AD. 15 In this study involving 91 AD patients, the authors determined that there was a relationship between the severity of AD and the neutrophil count, where the lymphocyte count had a negative correlation with the disease severity.…”

Section: Introductionmentioning

confidence: 99%

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The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

ÇİÇEK,

KANDEMİR,

KÖLE

2023

J Health Sci Med / JHSM

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Aims: We aimed to assess the association of hemogram parameters with atopic dermatitis (AD), severity of AD, and disease duration. Methods: We included the hemogram parameters of patients under follow-up in our pediatric allergy outpatient clinic and healthy group. The blood samples were drawn when they had no complaints or after at least 30 days of infection or a drug-free period. We built H1 and H0 (null) hypotheses, subjected data to Bayesian statistics, and assessed which hemogram parameters have potential and which shall not be used, with presenting evidence levels. We split the transactions into two groups (

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

ÇİÇEK,

KANDEMİR,

KÖLE

2023

J Health Sci Med / JHSM

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“…Easily accessible and practical laboratory tests can serve as valuable tools for assessing the severity of AD [ 24 ]. In this context, we investigated the relationship between serum vitamin D levels and the severity of AD, as well as the impact of other factors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Impact of Serum Vitamin D Levels on the Scoring Atopic Dermatitis Index in Pediatric Atopic Dermatitis

Çiçek,

Köle

2023

Children

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Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin condition characterized by itching, eczematous plaques, and dry skin. Despite ongoing research, its exact cause remains elusive. In this study, we aimed to explore the factors that influence the severity of AD in children and assess the relationship between serum vitamin D levels and the disease’s severity. We enrolled 96 AD patients in our investigation, evaluated their clinical condition using the Scoring Atopic Dermatitis (SCORAD) index, and compared them to a group of 90 healthy controls. Our analysis revealed that serum vitamin D levels and eosinophil counts significantly impacted the SCORAD index (p < 0.001). According to standardized regression coefficients, for each incremental unit in serum vitamin D levels, the SCORAD index exhibited a decrease of 0.449 units. Similarly, a one-unit increase in eosinophil count resulted in a 0.009 unit increase in the SCORAD index. It is worth noting that the influence of serum vitamin D levels on disease severity surpasses that of eosinophil counts and atopic conditions. In our patient cohort, we uncovered a negative correlation (r = −0.419, p < 0.001) between serum vitamin D levels and the SCORAD index. Our findings suggest that low serum vitamin D levels may have a more substantial impact on AD severity than atopic conditions and eosinophilia. Furthermore, we observed a negative association between the severity of AD and serum 25(OH)D3 levels.

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Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

Çevik,

Altas,

Altaş

et al. 2024

Acta Medica Nicomedia

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AOBJECTIVES: Atopic dermatitis (AD) is a chronic, recurrent, allergic inflammatory skin disease that may have a genetic predisposition. Eosinophilia is a common finding in patients with atopy. In our study, we aimed to investigate the relationship between eosinophil and IgE levels and allergy test results in patients with atopic dermatitis. METHODS: In this descriptive study, the files of patients diagnosed with atopic dermatitis and followed up in our Pediatric Allergy and Immunology Clinic between January 2021 and December 2022 were retrospectively reviewed. Age, gender, eosinophil, total IgE and specific IgE (for food and inhaled allergens) values were analyzed in the study. Skin prick test (SPT) was also performed in patients who had negative results for allergen-specific IgE. RESULTS: The absolute eosinophil count, eosinophil (%) and total IgE values of patients sensitized to at least one of the food and aeroallergens were significantly higher than those without allergen sensitization. The cut-off point of total IgE in predicting allergen sensitization was found to be 91.5 by ROC analysis. The sensitivity and specificity values for the cut-off point of total IgE were 73.3% and 72.9%. CONCLUSION: In this study, allergen sensitization was detected in 3 out of every 4 AD patients with total IgE and eosinophil values above the cut-off point we analyzed. Accordingly, we think that total IgE and eosinophil values are successful in predicting allergen sensitization. In clinics where specific IgE or SPT cannot be performed, eosinophil and total IgE values in whole blood will be useful for preliminary diagnosis.

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Retrospective investigation of the relationship between clinical and laboratory parameters and allergy tests in children with allergic rhinitis

Cited by 3 publications

References 24 publications

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

Evaluation of the Impact of Serum Vitamin D Levels on the Scoring Atopic Dermatitis Index in Pediatric Atopic Dermatitis

Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

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