Within department of dental surgery, patients with diabetes mellitus require particular approach during treatment, due to the impact on peripheral vascular system metabolism of this pathology. The study included 41 patients with various oral pathologies associated with diabetes mellitus, who weretreated in theDepartment of Oral Surgery within Dental Municipal Center in Chisinau. Out of 41 patients, 24 were female (58,5%), 21 were aged more than 60 years old (51,2%), meanwhile 37 patients were based in Chisinau (90,2%). Most common diagnosis was periodontitis, in 30 of cases (73,2%), while sinusitis– only 2 cases (4,9%). Odontectomy was the treatment of choice for 30 patients (73,2%). The ratio between diabetes mellitus type 1 and 2 represents 1:6. The blood glucose level increased by an average of 0,53 mmol/L, after intervention. Cardiovascular comorbidities were reported in 80,5% of cases. As paraclinical examination, orthopantomography was applied the most, 27 patients (65,9%). Surgical procedures, even the less invasive ones as odontectomy, can exert an influence on the endocrine system, underlined by several clinical signs, capable to cause significant risk for the patient’s state of health.