Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms

Veres, Cristina; Allodji, Rodrigue S.; Llanas, Damien; Bezin, Julien; Chavaudra, J.; Mège, J.-P.; Lefkopoulos, Dimitri; Quiniou, É.; Deutsh, Eric; Vathaire, Florent de; Diallo, Ibrahima

doi:10.1016/j.ijrobp.2014.08.335

Cited by 29 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, such images are taken with single energy CT and only used for anatomical referencing. Another benefit of whole body DECT would be for applications such as evaluating radiation dose from cancer treatment to the active marrow without assuming marrow composition from surrogate anatomy [37]. We expect these imaging studies to soon take advantage of reduced radiation exposure from DECT scans [38–40] and be able to monitor bone health.…”

Section: Discussionmentioning

confidence: 99%

Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

et al. 2016

View full text Add to dashboard Cite

Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual energy computed tomography (DECT) method to monitor MAT and marrow corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80kVp and 140kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences (p < 0.05) were found between QCT-derived vBMD and DECT-derived mcvBMD results. McvBMD was highly heterogeneous with a maximum at the posterior skull and minimum in the proximal humerus (574 mg/cc and 0.7 mg/cc, respectively). BV/TV and BMC have a nearly significant correlation with mcvBMD (r = 0.545, p=0.057 and r = 0.539, p=0.061, respectively). MAT assessed by DECT showed a significant correlation with MRI MAT results (r = 0.881, p<0.0001). Both DECT- and MRI-derived MAT had a significant influence on uncorrected vBMD (r = −0.86 and r = −0.818, p≤0.0001, respectively). Conversely, mcvBMD had no correlation with DECT- or MRI- derived MAT (r = 0.261 and r = 0.067). DECT can be used to assess MAT while simultaneously collecting mcvBMD values at each skeletal site. MAT is heterogeneous throughout the skeleton, highly variable, and should be accounted for in longitudinal mcvBMD studies. McvBMD accurately reflects the calcified tissue in cancellous bone.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Initial cancer treatment RT records were reviewed for all cases and controls. The review of RT dose, volume, and plan followed previously published procedures . One physician reviewed the operative notes, pathology reports, radiology reports, and any significant correspondence to determine the CRC location.…”

Section: Methodsmentioning

confidence: 99%

“…One physician reviewed the operative notes, pathology reports, radiology reports, and any significant correspondence to determine the CRC location. The dosimetry system used has previously been reported . It involved the use of a voxel‐based anthropomorphic phantom library to generate a surrogate of the whole body, as a computed tomography (CT) image for each patient who received RT, matching their dimensions.…”

Section: Methodsmentioning

confidence: 99%

“…The review of RT dose, volume, and plan followed previously published procedures. 20,21 One physician reviewed the operative notes, pathology reports, radiology reports, and any significant correspondence to determine the CRC location. The dosimetry system used has previously been reported.…”

Section: Estimation Of Radiation Dosementioning

confidence: 99%

“…The dosimetry system used has previously been reported. 20,21 It involved the use of a voxel-based anthropomorphic phantom library to generate a surrogate of the whole body, as a computed tomography (CT) image for each patient who received RT, matching their dimensions. Reconstitutions of the RT beams set up on the CT phantoms were developed using the Isogray (Dosisoft, Cachan, France) treatment planning system, implementing all of the features present to help with beam placement, as if the RT was being planned today (Supporting Information Figure S1).…”

Section: Estimation Of Radiation Dosementioning

confidence: 99%

See 2 more Smart Citations

Risk of subsequent colorectal cancers after a solid tumor in childhood: Effects of radiation therapy and chemotherapy

Allodji

Haddy

Vu‐Bezin

et al. 2018

Pediatric Blood & Cancer

Self Cite

View full text Add to dashboard Cite

Background Very few previous studies have addressed the question of colorectal cancer (CRC) after childhood cancer treatment. We aimed to quantify the roles of radiation therapy and chemotherapy agents in the occurrence of subsequent CRC. Methods A nested case–control study was conducted using 36 CRC cases and 140 controls selected from 7032 five‐year survivors of the French Childhood Cancer Survivor Study (FCCSS) cohort, treated from 1945 to 2000 in France. The radiation dose‐distribution metrics at the site of CRC and doses of individual chemotherapeutic agents were calculated. Conditional logistic regressions were performed to calculate odds ratios (ORs). Results Overall, patients who received radiotherapy with estimated dose to colon had a 4.3‐fold (95% CI, 1.3–17.6) increased risk for CRC compared with patients who did not receive radiotherapy, after adjustment for chemotherapy. This risk increased to 8.9‐fold and 19.3‐fold among patients who received radiation doses ranging from 20 to 29.99 Gy and ≥30 Gy, respectively. Our data reported a significantly elevated OR for anthracyclines, after controlling for radiotherapy and MOPP regimen. But, restricted analyses excluding patients who had received ≥30 Gy showed that only radiation doses ranging from 20 to 29.99 Gy produced a significant increase in subsequent CRC risk (OR = 7.8; 95% CI, 1.3–56.0), after controlling for anthracyclines and MOPP regimen. Conclusions The risk of subsequent CRC was significantly increased after radiation dose (even < 30 Gy). This novel finding supports the need to update monitoring guidelines for CRC to optimize the long‐term follow‐up for subsequent CRC in survivors of childhood cancer.

show abstract

The role of irradiated heart and left ventricular volumes in heart failure occurrence after childhood cancer

Mansouri

Allodji

Hill

et al. 2018

European J of Heart Fail

Self Cite

View full text Add to dashboard Cite

Background Paediatric cancer survivors have a high risk of developing cardiac diseases, and the most frequent cardiac disease is heart failure (HF). The radiation dose–volume effects in the heart and cardiac substructures have not been explored in childhood cancer survivors (CCS). Therefore, the role of irradiated heart volume in the occurrence of HF among this population remains unclear. The aims of this study were to determine the doses and irradiated volumes of the heart and left ventricle (LV) related to the risk of HF in CCS and to investigate the impact of anthracycline exposure on this risk. Methods and results A case‐control study nested in the French Childhood Cancer Survivors Study cohort. The mean heart and left ventricular doses and volumes indicators were estimated by reconstruction of individual treatments. A total of 239 HF cases and 1042 matched controls were included. The median age of HF diagnosis was 25.1 years. The median volume of the heart that received ≥ 30 Gy was 61.1% for cases and 16.9% for controls. In patients who did not receive anthracycline, the risk of HF was increased 3.6‐fold when less than 10% of the LV received ≥ 30 Gy when compared to patients who were not exposed to any cardiac radiation and anthracycline. Conclusions Small irradiated volumes of the heart or LV were significantly associated with HF risk. To the author's knowledge, this is the first study to report a dose–response relationship based on dose–volume indicators in CCS, which can be translated efficiently into current clinical practice.

show abstract

Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms

Cited by 29 publications

References 15 publications

Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

Risk of subsequent colorectal cancers after a solid tumor in childhood: Effects of radiation therapy and chemotherapy

The role of irradiated heart and left ventricular volumes in heart failure occurrence after childhood cancer

Contact Info

Product

Resources

About