Retrospective Review of Adverse Reaction Profile of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

Mertz, Thomas L.; Peric, A.N.; Ishmael, Faoud T.

doi:10.1016/j.jaci.2011.12.526

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BBs have been shown to induce side effects on the central nervous system, cardiovascular system and digestive system. Statins have significant hepatotoxicity, and antiplatelet adjunctive therapies are associated with an increased risk of bleeding and gastrointestinal damage (Beltowski et al, 2009;Mertz et al, 2012;Navarese et al, 2014;Yebra-Yebra et al, 2010). Traditional Chinese medicine (TCM) has been widely used for the prevention and treatment of cardiovascular diseases in East Asia, such as Korea, Japan and China.…”

Section: Introductionmentioning

confidence: 99%

Identification of NF‐κB inhibitors in Qishenyiqi dropping pills for myocardial infarction treatment based on bioactivity‐integrated UPLC‐Q/TOF MS

Han

Zhou

Xing

et al. 2015

Biomedical Chromatography

View full text Add to dashboard Cite

Qishenyiqi dropping pills (QSYQ) are a type of standardized cardiovascular multiherb medicine for the treatment of myocardial infarction (MI). Knowledge concerning the systemic identification of nuclear factor-kappa B (NF-κB) inhibitors of QSYQ is generally lacking. Therefore, it is necessary to establish an effective method to screen the bioactive components of NF-κB inhibition. In the present study, a rat model of coronary artery ligation was used to assess the cardioprotective effects of QSYQ. The electrocardiograms, histopathology of heart tissues and serum biochemical indicators, such as brain natriuretic peptide, cardiac troponin I and inflammatory cytokines, were measured. Subsequently, ultra-performance liquid chromatography quadrupole/time-of-flight mass spectrometry (UPLC-Q/TOF MS) combined with the NF-κB luciferase reporter assay system was applied to screen the potential anti-inflammatory compounds in QSYQ. The results revealed that the administration of QSYQ could improve heart function, ameliorate neutrophil infiltration and diminish the levels of inflammatory cytokines in MI rats. Furthermore, 22 compounds were determined to be potential NF-κB inhibitors. In conclusion, NF-κB inactivation and cytokine suppression might be the main mechanisms of QSYQ for MI treatment. The method of UPLC-Q/TOF MS combined with a bioactive human cell functional evaluation system was proved to be a simple and effective strategy for screening bioactive compounds in traditional Chinese medicine prescriptions.

show abstract

Section: Introductionmentioning

confidence: 99%