Retrospective Review of the Clinical Manifestations and Outcomes in Puerto Ricans with Idiopathic Inflammatory Myopathies

Ríos, Grissel

doi:10.1097/01.rhu.0000164820.46979.52

Cited by 19 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This retrospective study of 188 IIM patients is more representative of overall IIM patients. The overall mortality in our study was 17%, similar to other published series [11,18,31,37], but lower than that Troyanov Y reported [7]. Importantly, our results indicated that cumulative survival rate was better than other series reported over 15 years (Table 5) [7,9-12,15,29,32,33].…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Clinical characteristics and favorable long-term outcomes for patients with idiopathic inflammatory myopathies: a retrospective single center study in China

Shu

Xie

et al. 2011

BMC Neurol

View full text Add to dashboard Cite

BackgroundLittle is known about the clinical features and true survival risk factors in Chinese Han population. We conducted the current study to investigate the clinical features, long-term outcome and true potential indicators associated with mortality of idiopathic inflammatory myopathies (IIM) in China.MethodsWe restrospectvely investigated 188 patients diagnosed with IIM at our hospital from January 1986 to April 2009. The primary outcome was determined with mortality. The secondary outcomes for survival patients were organ damage and disease activity, health status, and disability, which were assessed with Myositis Damage Index, Myositis Disease Activity Assessment Visual Analogue Scales, Health Assessment Questionnaire Disability Index, and the Modified Rankin Scale, respectively. Potential prognostic factors for mortality were analyzed with the multivariate Cox regression model.ResultsMean age at disease onset was 43.8 ± 15.8 years and male to female ratio was 1:2.1 in this cohort. The 1-, 5-, 10-, 15- and 20-year survival rates were 93.6%, 88.7%, 81%, 73.6% and 65.6%. The independent predicators for mortality were age at disease onset [hazard ratio (HR):1.05, 95% CI 1.02 - 1.08], presence of cancer (HR:3.68, 95%CI 1.39 - 9.74), and elevated IgA level at diagnosis (HR:2.80, 95% CI 1.16-6.74). At the end of the follow-up, 29 patients manifested drug withdrawal within an average 4.1 years (range 0.5-15.2 year), most patients (85.9%) had no disease activity and 130 patients (83.4%) had no disability.ConclusionsThe long-term outcomes of IIM patients in our cohort have improved dramatically. Those patients most likely to survive had a high chance of reaching stable disease status, and obtained long-term or possibly permanent remission to a large extent.

show abstract

Section: Discussionsupporting

confidence: 86%

“…There is still some debate on the relationship between skin ulcer and outcome. Several studies showed that skin ulcer was not associated with the risk of mortality in Chinese Han patients and Caucasian patients [8-10,13,15,17,20,33,32,37]. …”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and favorable long-term outcomes for patients with idiopathic inflammatory myopathies: a retrospective single center study in China

Shu

Xie

et al. 2011

BMC Neurol

View full text Add to dashboard Cite

show abstract

“…[13151821–23] CPK was elevated in 85% of cases in the current study, which was higher than that described by DeVere et al . [13] who found CPK elevation in 64% of cases.…”

Section: Discussioncontrasting

confidence: 86%

“…One-fourth of our patients had bulbar muscle weakness at the time of initial evaluation, whereas it was only 10% in a study published by Rios et al . [21]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical, electrophysiologic, and histopathologic profile, and outcome in idiopathic inflammatory myositis: An analysis of 68 cases

Ramesha

Kuruvilla

Sarma

et al. 2010

Ann Indian Acad Neurol

View full text Add to dashboard Cite

Objectives:To study the electroclinical and histopathologic profile of idiopathic inflammatory myositis (IIM) with reference to prognosis and survival rate.Materials and Methods:Diagnosis of IIM was based on the Bohan and Peter criteria. Patients who improved and those whose condition worsened or who expired due to IIM per se at last follow-up were classified to have favorable and poor outcomes, respectively. Fisher’s exact test was used for univariate analysis of prognostic factors.Results:The study cohort consisted of consecutive 68 patients with IIM. The mean age at diagnosis was 36.5 years and females constituted 71%. Of these patients, 62% had definite IIM, 49% had polymyositis, 20% had dermatomyositis, and 29% had overlap syndrome. The mean follow-up period was 5.4 years. Prednisolone alone was used in 55 (80%), and azathioprine (1–3 mg/kg/day) alone in 12 (17.6%) as the initial treatment. Relapse of IIM with drug withdrawal was seen in 15 patients (22%); 70% had favorable outcome and 16% had expired. The treatment delay of ≤6 months (P = 0.001), absence of cardiac or lung involvement (P < 0.001), and positive biopsy (P = 0.033) were predictive of a favorable prognosis in the univariate analysis. In multivariate analysis, only the duration of illness of ≤6 months (P = 0.008) and the absence of cardiac or lung involvement (P = 0.001) predicted the favorable outcome at last follow-up. Cumulative survival rate was 95% at 1 year, 86% at the 5th year, and 80% at the 10th year.Conclusions:Approximately, two-thirds of the patients showed good electroclinical and histopathologic correlations and an equal number improved with treatment. The treatment delay (≥6 months), presence of cardiac or pulmonary involvements, and negative muscle biopsy are bad prognostic factors.

show abstract

Cutaneous manifestations of systemic diseases in Afro‐Caribbean skin

Cordel

2024

JEADV Clinical Practice

View full text Add to dashboard Cite

show abstract

Retrospective Review of the Clinical Manifestations and Outcomes in Puerto Ricans with Idiopathic Inflammatory Myopathies

Abstract: Puerto Ricans with IIM in this survey showed a low presence of visceral involvement, high remission rate, and low mortality.

Cited by 19 publications

References 15 publications

Clinical characteristics and favorable long-term outcomes for patients with idiopathic inflammatory myopathies: a retrospective single center study in China

Clinical characteristics and favorable long-term outcomes for patients with idiopathic inflammatory myopathies: a retrospective single center study in China

Clinical, electrophysiologic, and histopathologic profile, and outcome in idiopathic inflammatory myositis: An analysis of 68 cases

Cutaneous manifestations of systemic diseases in Afro‐Caribbean skin

Contact Info

Product

Resources

About