Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Turinelli, Vanessa; Gavazza, Alessandra

doi:10.1177/1098612x18757602

Cited by 10 publications

(12 citation statements)

References 15 publications

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“…There was no statistical association between the leukogram results and retroviral infection, reinforcing the hypothesis of the absence of bone marrow involvement. Changes in the total leukocyte count are related to the reduction in the number of circulating neutrophils, mainly in the acute phase of infections and later in the immunosuppression phase, due to insufficient myelopoiesis (Shelton et al, 1990;Costa et al, 2017;Turinelli & Gavazza, 2018). Lymphopenia is related to the onset of immunosuppression, with a decrease in the number of CD4 and CD8 cells (Hofmann-Lehmann et al, 1997;Novo et al, 2016;Little et al, 2020 Regarding biochemical changes, we observed a tendency towards hyperproteinemia in FIV positive cats.…”

Section: Discussionmentioning

confidence: 77%

Hematological and biochemical aspects of cats naturally infected with feline immunodeficiency virus and feline leukemia

et al. 2020

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Considering the importance and severity of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections, information on laboratory abnormalities can determine the prognosis of infected cats. This study aimed to determine the laboratory alterations of domiciled asymptomatics cats naturally infected by FIV and/or FeLV in Northeastern Brazil. Blood samples from 200 cats were evaluated by nested-PCR and commercial immunochromatographic test for diagnosis of these infections. Complete blood count (CBC) and serum biochemistry analyses were performed to evaluate laboratory abnormalities. CBC and biochemical values of cats tested positive for FIV and/or FeLV were tabulated for the presence or absence of changes and analyzed using the chi-square test with Yates correction or Fisher's exact test for each variable, with a confidence interval of 95%. The total frequency was 6% (12/200) and 3% (6/200) for FIV and FeLV, respectively. The presence of hyperbilirubinemia (total, direct, and indirect) was the only change observed in cats positive for FIV compared to FIV-negative controls (p<0.05). We believe that laboratory changes compatible with immunosuppressive conditions should be more frequent in FIV/FeLV positive cats that already present clinical signs of the disease.

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Section: Discussionmentioning

confidence: 77%

Hematological and biochemical aspects of cats naturally infected with feline immunodeficiency virus and feline leukemia

et al. 2020

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“…5,6 Erythroid hypoplasia was defined as a normal or decreased BM cellularity with an M:E ratio above 2.16. 5 Pure red cell aplasia was defined as a severe increase in the M:E ratio above 75:1 along with a non-regenerative anaemia. 6 Medical records were reviewed for those cases that had BM cytology and/or histology available.…”

Section: Methodsmentioning

confidence: 99%

“…At the time of diagnosis, BM samples were microscopically evaluated (including a differential cell count). The BM samples were classified as erythroid hyperplasia when cellularity was normal or increased and the myeloid:erythroid (M:E) ratio was below 1.2 5,6 . Erythroid hypoplasia was defined as a normal or decreased BM cellularity with an M:E ratio above 2.16 5 .…”

Section: Methodsmentioning

confidence: 99%

“…The BM samples were classified as erythroid hyperplasia when cellularity was normal or increased and the myeloid:erythroid (M:E) ratio was below 1.2 5,6 . Erythroid hypoplasia was defined as a normal or decreased BM cellularity with an M:E ratio above 2.16 5 . Pure red cell aplasia was defined as a severe increase in the M:E ratio above 75:1 along with a non‐regenerative anaemia 6 …”

Section: Methodsmentioning

confidence: 99%

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Clinical findings, treatment and outcome in cats diagnosed with precursor‐targeted immune‐mediated anaemia in a referral hospital in the UK: 30 cases (2010–2021)

Maldonado‐Moreno,

Seth,

Monti

et al. 2023

Veterinary Record Open

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AimsThis retrospective study aimed to report clinical findings, treatment response and survival in cats diagnosed with precursor‐targeted immune‐mediated anaemia (PIMA) in a referral hospital in the UK.MethodsFeline cases diagnosed with presumed PIMA between January 2010 and February 2021 were retrospectively recruited. Signalment, clinical signs, diagnostic tests, treatment and outcome were recorded. Descriptive analytics were performed. Outcomes were documented according to survival to discharge, 30‐day survival, total survival time, response to immunosuppressive treatment and frequency of relapses.ResultsThirty cats met the inclusion criteria. A higher prevalence of females (19/30) was identified (p = 0.001). Most cats (25/30) presented with haematocrit below 0.15 L/L. Concurrent cytopenias occurred in 18 of 30 cats. Bone marrow diagnosis was erythroid hyperplasia in 24 of 30 cases. Survival to discharge was documented in 26 of 30 cats, of which 23 survived more than 30 days since diagnosis. Initial treatment included blood products (26/30) and prednisolone (26/30) or prednisolone with ciclosporin (3/30); 18 of 30 cats responded to treatment, with a normal haematocrit at a mean of 28 days. The initial haematocrit and the presence of concurrent cytopenia were not statistically different between responders and non‐responders. The median survival time was 140 days (range 1–3930 days).Conclusions and relevanceThe treatment response rate of feline PIMA was high (60%), with a mortality rate of 23% over the 30 days following diagnosis. Relapses occur frequently (77%) but the response rate after treatment modification was high (76%) and therefore ongoing treatment may be justified at that point. Long survival times (up to 3930 days) can be achieved.

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“…. Em outro estudo, apenas 16% dos gatos com LLA apresentaram linfocitose acentuada (mais de 14.000 céls/μL), mas apesar de uma quantidade semelhante de células por µL a(HARVEY, 2012;TURINELLI & GAVAZZA, 2018). Contudo, neste estudo, foram encontrados blastos no sangue de apenas três dos gatos, que representaram os únicos com linfocitose superior a 100.000/µL, podendo indicar quadro mais avançado.…”

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Leucemia linfoide aguda em gatos infectados pelo vírus da leucemia felina com diagnóstico presuntivo de 12 casos

Paixão¹,

Paixão

Silvestre³

et al. 2021

CONJ

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A leucemia é definida como uma neoplasia de células hematopoiéticas. Pode ser classificada em quadros agudos ou crônicos, sendo o vírus da FeLV intimamente ligado a causa de leucemias agudas. Em caráter retrospectivo, nove animais diagnosticados FeLV positivos, com a evidenciação de bicitopenia, associada ao predomínio de linfócitos (superior a 80%) foram selecionados para uma análise hematológica. Todos os animais apresentaram linfocitose acentuada (> 13.000 céls/μL) e em apenas dois gatos foram encontrados linfoblastos. O protocolo quimioterápico Wisconsin-Madison modificado foi realizado em quatro gatos, mas somente o gato 7 sobreviveu e obteve melhora do quadro clínico. Os nove gatos avaliados neste trabalho apresentaram características compatíveis com um quadro leucêmico agudo, tendo uma sobrevida de 16 dias, o que indica ser uma enfermidade de curso rápido e prognóstico ruim, dificultando a realização de exames mais complexos para um diagnóstico definitivo.

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Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Abstract: This study provides a general overview of the prevalence and incidence of feline bone marrow disorders together with ranges for differential nucleated cell counts and M:E ratios for the various conditions reported.

Cited by 10 publications

References 15 publications

Hematological and biochemical aspects of cats naturally infected with feline immunodeficiency virus and feline leukemia

Hematological and biochemical aspects of cats naturally infected with feline immunodeficiency virus and feline leukemia

Clinical findings, treatment and outcome in cats diagnosed with precursor‐targeted immune‐mediated anaemia in a referral hospital in the UK: 30 cases (2010–2021)

Leucemia linfoide aguda em gatos infectados pelo vírus da leucemia felina com diagnóstico presuntivo de 12 casos

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