Purpose-To determine long-term stability of maxillomandibular advancement (MMA) in patients with obstructive sleep apnea (OSA).Materials and Methods-This was a retrospective cohort study of patients who underwent MMA and genial tubercle advancement (GTA) for treatment of OSA. Patients were included who were over 19 years of age, had a confirmatory polysomnogram, underwent a LeFort I osteotomy, bilateral sagittal split osteotomies and GTA, had adequate radiographic documentation and at least 11 months follow-up. Exclusion criteria included previous history of orthognathic or other maxillofacial surgery. Predictor variables were presence of OSA treated by MMA, pre and postoperative orthodontia or no orthodontia, length of follow-up and magnitude of advancement. Outcome variable was stability of MMA judged by clinical examination and cephalometric measurements. Standardized lateral cephalometric measurements were done at T0, preoperative; T1 immediate postoperative; T2, latest follow-up >11 months. Differences in cephalometric measurements were calculated between time points T1-T0 and T2-T1 for the overall group and for patients who had orthodontia (Group 1) and those who did not (Group 2). A correlation analysis using length of follow-up and magnitude of advancement as predictor variables of stability were completed. For all analyses, P < .05 was considered statistically significant.Results-During the 9 year study period 120 patients with OSA were evaluated and 112 had operative treatment; twenty-five patients specifically had MMA and GTA, met inclusion criteria and formed the study sample. Mean and range of maxillary and mandibular advancements (T1-T0) were 9.48 mm (range, 1.6-15.2) and 10.85 mm (range, 6.3-15.8) respectively. At T2-T1, no
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Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript occlusal changes occurred. Changes in the subgroup analyses included a decrease in SNA and ANB and an increase in MnPl-SN in Group 1 and a decrease in ANB in Group 2. The only significant mean difference in cephalometric measurements between the groups was in Co-Gn. There was no correlation between length of follow-up (mean 27.84 months) and changes in cephalometric measurements.Conclusion-Results of this study indicate that while there were changes in SNA and ANB between T1 and T2 suggesting maxillary relapse, the mean difference was ≤1 degree and no patients developed a malocclusion; therefore we considered the changes clinically insignificant. Advancement of the maxillomandibular complex 10 mm for treatment OSA remains stable at a mean followup period greater than 2 years and preoperative orthodontic treatment does not appear to influence skeletal stability.