Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India

Kundavaram, Abhilash; Selvan, Saravanan; Raja, V. Pragadeesh; Mathiyalagan, Ponnivalavan; Kanagarajan, Rohini; Reddy, Narmadha P; Rajendiran, Natarajan; Hazra, Darpanarayan; Gunasekaran, Karthik; Moorthy, Mahesh; Lenin, Audrin; Mathew, Divya Elizabeth; Iyyadurai, Ramya; Varghese, George; Dj, Christopher; Joy, Melvin; Peter, John Victor

doi:10.1136/bmjopen-2022-062724

Cited by 3 publications

(2 citation statements)

References 14 publications

(24 reference statements)

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“…However, it was lower in the fourth wave with 1.2%. It might be due to the vaccination effect among healthcare workers in the fourth wave, and the finding is similar to a retrospective study in India [17].…”

Section: Strobe: Strengthening the Reporting Of Observational Studies...supporting

confidence: 85%

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Kyu¹,

Ko²,

Lwin³

et al. 2023

Cureus

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IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, private hospitals in Mandalay started to manage COVID-19 infections according to national treatment guidelines since February 2021. Variations of clinical characteristics and their outcomes in different surges could be evaluated in the private hospital. This study aimed to assess the clinical profile and outcomes of COVID-19 patients admitted at a private hospital during three surges in Mandalay. MethodsThis study is a retrospective record review of the case series of COVID-19 patients admitted at

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Section: Strobe: Strengthening the Reporting Of Observational Studies...supporting

confidence: 85%

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Kyu¹,

Ko²,

Lwin³

et al. 2023

Cureus

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“…AKI in hospitalized patients is associated with an almost two times greater length of hospitalization and costs, therefore consuming a large amount of human, infrastructural and economic resources [14,15]. Whereas low-and middle-income countries suffered from a shortage of basic health care resources and the collapse of their health care systems in the second wave of the pandemic, high-income countries reported a reduction in in-hospital COVID-19 patient lethality over the same period of time [16,17].…”

Section: Introductionmentioning

confidence: 99%

Critically ill patients with COVID-19-associated acute kidney injury treated with kidney replacement therapy: Comparison between the first and second pandemic waves in São Paulo, Brazil

Samaan,

Freitas,

Viana

et al. 2023

PLoS ONE

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Introduction This study aimed to compare the characteristics and outcomes of critically ill patients with COVID-19-associated acute kidney injury (AKI) who were treated with kidney replacement therapy (KRT) in the first and second waves of the pandemic in the megalopolis of Sao Paulo, Brazil. Methods A multicenter retrospective study was conducted in 10 intensive care units (ICUs). Patients aged ≥18 years, and treated with KRT due to COVID-19-associated AKI were included. We compared demographic, laboratory and clinical data, KRT parameters and patient outcomes in the first and second COVID-19 waves. Results We assessed 656 patients (327 in the first wave and 329 in the second one). Second-wave patients were admitted later (7.1±5.0 vs. 5.6±3.9 days after the onset of symptoms, p<0.001), were younger (61.4±13.7 vs. 63.8±13.6 years, p = 0.023), had a lower frequency of diabetes (37.1% vs. 47.1%, p = 0.009) and obesity (29.5% vs. 40.0%, p = 0.007), had a greater need for vasopressors (93.3% vs. 84.6%, p<0.001) and mechanical ventilation (95.7% vs. 87.8%, p<0.001), and had higher lethality (84.8% vs. 72.7%, p<0.001) than first-wave patients. KRT quality markers were independently associated with a reduction in the OR for death in both pandemic waves. Conclusions In the Sao Paulo megalopolis, the lethality of critically ill patients with COVID-19-associated AKI treated with KRT was higher in the second wave of the pandemic, despite these patients being younger and having fewer comorbidities. Potential factors related to this poor outcome were difficulties in health care access, lack of intra-hospital resources, delay vaccination and virus variants.

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Features of the covid-19 epidemic and characteristics of patients during the spread of the delta SARS-COV-2 in Russia

Fomicheva,

Pimenov,

Komarova

et al. 2024

jour

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Aim: To study the manifestations of the COVID-19 epidemic and the clinical and epidemiological characteristics of adult patients with a new coronavirus infection during the dominance of the Delta SARS-COV-2 in the Russian Federation.Materials and Methods: Study included patients aged ≥18 years with a laboratory-confirmed diagnosis of COVID-19, detected in the period from 09/01/2021 to 11/30/2021 (n= 2 619 298) in 85 Russian regions.Results: There were 2 periods of rise and decline in the COVID-19 incidence and mortality during the spread of the Delta SARS-CoV-2 in Russia: June-September and OctoberDecember 2021 (Wald – Wolfowitz criterion, p<0,05). The median age of patients was 49 [36–63] years, 61,1% were women. Most of patients were 30–39 years old (21,0%), the lowest proportion was among 18–29 years old (12.1%) (p<0,05). Proportion of patients with mild disease was 75,4%, moderate – 18,8%, severe – 3,3%, extremely severe – 2,5% (p<0.05). Hospitalization rate was 23,7%, proportion of patients treated in the intensive care unit was 12.9%, and rate of invasive mechanical ventilation was 9,8%. The median period from the onset of symptoms to the diagnosis was 3 [1-6] days, the duration of the disease and hospitalization was 13,0 [10–16] and 12,0 [9–17] days, respectively. The median age of the deceased patients was 73 [65–82] years, of which 59,1% were women, 61,5% were persons ≥70 years old. The presence of one or more comorbidities was found in 73,9% of deceased patients (OR=17,1; 95% CI: 16,8–17,3).Conclusion: during the period of the spread of the Delta SARS-COV-2 variant in Russia, the number of patients with severe and extremely severe disease among adult patients without taking into account the vaccine history was 5,8%. Old age and the presence of concomitant diseases were key risk factors for adverse outcomes of COVID-19.

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Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India

Cited by 3 publications

References 14 publications

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Critically ill patients with COVID-19-associated acute kidney injury treated with kidney replacement therapy: Comparison between the first and second pandemic waves in São Paulo, Brazil

Features of the covid-19 epidemic and characteristics of patients during the spread of the delta SARS-COV-2 in Russia

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